Hypoxia in solid tumors: a key promoter of cancer stem cell (CSC) resistance

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

(2019) Mutsuko Minata et al.   Cell Reports

Aspirin inhibits hypoxia-mediated lung cancer cell stemness and exosome function

(2019) Jinghua Chen et al.   PATHOLOGY RESEARCH AND PRACTICE

Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cells

(2019) Kumari Anuja et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy

(2019) Hongjuan Li et al.   BIOMATERIALS

Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy

(2019) Jiyeong Lee et al.   EUROPEAN RADIOLOGY

High density is a property of slow-cycling and treatment-resistant human glioblastoma cells

(2019) Hanna Sabelström et al.   EXPERIMENTAL CELL RESEARCH

Hypoxia‐induced secretion stimulates breast cancer stem cell regulatory signalling pathways

(2019) Hanna Jacobsson et al.   Molecular Oncology

Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor

(2019) Chiu-Min Lin et al.   Frontiers in Oncology

Monitoring tumour microenvironment changes during anti-angiogenesis therapy using functional MRI

(2019) Jianye Liang et al.   ANGIOGENESIS

MYC Regulates the HIF2α Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells

(2019) Bikul Das et al.   CANCER RESEARCH

Cancer stem cell (CSC) resistance drivers

(2019) Masoud Najafi et al.   LIFE SCIENCES

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

(2018) Jianghong Man et al.   Cell Stem Cell

Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer

(2018) Jennifer Haynes et al.   CLINICAL CANCER RESEARCH

COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment

(2018) Xiao-Feng Dong et al.   CLINICAL CANCER RESEARCH

In vivo tumor gene delivery using novel peptideticles: pH-responsive and ligand targeted core-shell nanoassembly

(2018) Mohsen Alipour et al.   INTERNATIONAL JOURNAL OF CANCER

Intermittent hypoxia induces a metastatic phenotype in breast cancer

(2018) Anna Chen et al.   ONCOGENE

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-dependent CD51 expression contributes to characteristics of cancer stem cells in prostate cancer

(2018) Xin Sui et al.   Cell Death & Disease

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer

(2018) James R.W. Conway et al.   Cell Reports

Paracrine HGF/c-MET enhances the stem cell-like potential and glycolysis of pancreatic cancer cells via activation of YAP/HIF-1α

(2018) Bin Yan et al.   EXPERIMENTAL CELL RESEARCH

Cancer stem cells (CSCs) in cancer progression and therapy

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CD8+ cytotoxic T lymphocytes in cancer immunotherapy: A review

(2018) Bagher Farhood et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIF-2α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways

(2018) Yuanyuan Yan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hypoxia potentiates gemcitabine-induced stemness in pancreatic cancer cells through AKT/Notch1 signaling

(2018) Zhengle Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Development of a Non-invasive Assessment of Hypoxia and Neovascularization with Magnetic Resonance Imaging in Benign and Malignant Breast Tumors: Initial Results

(2018) Andreas Stadlbauer et al.   MOLECULAR IMAGING AND BIOLOGY

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

(2017) Catharina Melzer et al.   Molecular Cancer

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

(2017) Qi Zhang et al.   Molecular Cancer

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells

(2017) Nicole Colwell et al.   NEURO-ONCOLOGY

Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia

(2017) D A Almiron Bonnin et al.   ONCOGENE

HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

(2017) Pan Wang et al.   Scientific Reports

Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression

(2017) Jie Qin et al.   Scientific Reports

The hypoxic tumor microenvironment: A driving force for breast cancer progression

(2016) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The hypoxic microenvironment: A determinant of cancer stem cell evolution

(2016) Amancio Carnero et al.   BIOESSAYS

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

(2016) Alan McIntyre et al.   CANCER RESEARCH

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Cisplatin treatment increases stemness through upregulation of hypoxia-inducible factors by interleukin-6 in non-small cell lung cancer

(2016) Fuquan Zhang et al.   CANCER SCIENCE

The Potent Inhibitory Effect of a Naproxen-Appended Cobalt(III)-Cyclam Complex on Cancer Stem Cells

(2016) Paul B. Cressey et al.   CHEMBIOCHEM

Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways

(2016) U.D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

Transforming growth factor-β and stem cell markers are highly expressed around necrotic areas in glioblastoma

(2016) Yasuo Iwadate et al.   JOURNAL OF NEURO-ONCOLOGY

Dynamic regulation of stem cell specification and maintenance by hypoxia-inducible factors

(2016) Gregg L. Semenza   MOLECULAR ASPECTS OF MEDICINE

Cancer stem cell metabolism: a potential target for cancer therapy

(2016) Abhijeet Deshmukh et al.   Molecular Cancer

Hypoxic and Reoxygenated Microenvironment: Stemness and Differentiation State in Glioblastoma

(2016) Mariana Maier Gaelzer et al.   MOLECULAR NEUROBIOLOGY

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

(2016) Rachelle W. Johnson et al.   NATURE CELL BIOLOGY

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

2-Methoxyestradiol inhibits the proliferation and migration and reduces the radioresistance of nasopharyngeal carcinoma CNE-2 stem cells via NF-κB/HIF-1 signaling pathway inactivation and EMT reversal

(2016) Shun-Long Wu et al.   ONCOLOGY REPORTS

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

The tumor microenvironment: An irreplaceable element of tumor budding and epithelial-mesenchymal transition-mediated cancer metastasis

(2016) Hui Li et al.   Cell Adhesion & Migration

STAT3 is a key transcriptional regulator of cancer stem cell marker CD133 in HCC

(2016) Sarani Ghoshal et al.   HEPATOBILIARY SURGERY AND NUTRITION

CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer

(2015) Sarah J. Conley et al.   BREAST CANCER RESEARCH AND TREATMENT

The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?

(2015) Vicki Plaks et al.   Cell Stem Cell

Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients

(2015) M. C. de Jong et al.   CLINICAL CANCER RESEARCH

The use of plant-derived bioactive compounds to target cancer stem cells and modulate tumor microenvironment

(2015) Francesca Pistollato et al.   FOOD AND CHEMICAL TOXICOLOGY

Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma

(2015) Cheolhee Won et al.   HEPATOLOGY

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-α Signaling

(2015) Hui Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

(2015) Xiaonan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

(2015) Haiquan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets

(2015) Mark A. Feitelson et al.   SEMINARS IN CANCER BIOLOGY

Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential Mechanism

(2015) Peter Csermely et al.   SEMINARS IN CANCER BIOLOGY

Gd-metallofullerenol nanomaterial as non-toxic breast cancer stem cell-specific inhibitor

(2015) Ying Liu et al.   Nature Communications

Urokinase receptor and resistance to targeted anticancer agents

(2015) Steven L. Gonias et al.   Frontiers in Pharmacology

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer

(2014) M. Varna et al.   CLINICAL CANCER RESEARCH

The network of epithelial–mesenchymal transition: potential new targets for tumor resistance

(2014) Danupon Nantajit et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells

(2014) Maximilian Marhold et al.   MOLECULAR CANCER RESEARCH

The role of cancer stem cells in glioblastoma

(2014) Swetha J. Sundar et al.   Neurosurgical Focus

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

(2014) Twan van den Beucken et al.   Nature Communications

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Nanomedicine therapeutic approaches to overcome cancer drug resistance

(2013) Janet L. Markman et al.   ADVANCED DRUG DELIVERY REVIEWS

Role of integrated cancer nanomedicine in overcoming drug resistance

(2013) Arun K. Iyer et al.   ADVANCED DRUG DELIVERY REVIEWS

Slug/β-Catenin–Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells

(2013) Gianluca Storci et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia After Liver Surgery Imposes an Aggressive Cancer Stem Cell Phenotype on Residual Tumor Cells

(2013) Klaas M. Govaert et al.   ANNALS OF SURGERY

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

(2013) Haitao Zhu et al.   Cancer Cell International

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer

(2013) Kousuke Hashimoto et al.   Gastric Cancer

Visualization of stem cell features in human hepatocellular carcinoma revealsin vivosignificance of tumor-host interaction and clinical course

(2013) Shunsuke Muramatsu et al.   HEPATOLOGY

Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

(2013) Li Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Brain tumor stem cells: Molecular characteristics and their impact on therapy

(2013) David L. Schonberg et al.   MOLECULAR ASPECTS OF MEDICINE

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness

(2012) Bin Bao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications

(2012) Liuqi Yang et al.   EXPERIMENTAL CELL RESEARCH

Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia

(2012) Annamaria Rapisarda et al.   Nature Reviews Clinical Oncology

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

Targeting cancer-initiating cell drug-resistance: a roadmap to a new-generation of cancer therapies?

(2011) Angela Alama et al.   DRUG DISCOVERY TODAY

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

(2011) F Xing et al.   ONCOGENE

EMT: New signals from the invasive front

(2011) Xinhua Liang   ORAL ONCOLOGY

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Epithelial-Mesenchymal Transition in tumor microenvironment

(2011) Yingying Jing et al.   Cell and Bioscience

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

Metastasis: cancer cell’s escape from oxidative stress

(2010) Giovambattista Pani et al.   CANCER AND METASTASIS REVIEWS

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

(2010) Zhi Huang et al.   Protein & Cell

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS