Hypoxia-inducible factor 1α plays a predominantly negative role in regulatory T cell functions

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells

(2018) Wan-Chen Hsieh et al.   Nature Communications

HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

(2017) Yushi Yao et al.   Journal of Translational Medicine

Stability and function of regulatory T cells expressing the transcription factor T-bet

(2017) Andrew G. Levine et al.   NATURE

A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke

(2017) Hsu-Tung Lee et al.   Theranostics

IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells

(2017) Lea M. Feldhoff et al.   Scientific Reports

Tissue Tregs

(2016) Marisella Panduro et al.   Annual Review of Immunology

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

(2016) David Clever et al.   CELL

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-dependent regulation of inflammatory pathways in immune cells

(2016) Cormac T. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Prolyl hydroxylase 3 (PHD3) expression augments the development of regulatory T cells

(2016) Yogesh Singh et al.   MOLECULAR IMMUNOLOGY

Hypoxia-inducible factors in T lymphocyte differentiation and function. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Jin-Hui Tao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The therapeutic potential of regulatory T cells for the treatment of autoimmune disease

(2015) Jeffrey A Bluestone et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity

(2015) Jee H. Lee et al.   IMMUNITY

Ubiquitin-dependent regulation of Foxp3 and Treg function

(2015) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Cutting Edge: Hypoxia-Inducible Factor 1 Negatively Regulates Th1 Function

(2015) Hussein Shehade et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis

(2015) K Flück et al.   Mucosal Immunology

Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+T cells through IL-12 and TGF-β1

(2015) Guangwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Individual intestinal symbionts induce a distinct population of ROR + regulatory T cells

(2015) E. Sefik et al.   SCIENCE

Hurdles in therapy with regulatory T cells

(2015) Piotr Trzonkowski et al.   Science Translational Medicine

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210

(2014) Haopeng Wang et al.   NATURE IMMUNOLOGY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

The heterogeneous immune microenvironment in breast cancer is affected by hypoxia-related genes

(2013) Markus Duechler et al.   IMMUNOBIOLOGY

Metabolic control of the Treg/Th17 axis

(2013) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Overexpression of hypoxia-inducible factor 1 alpha impacts FoxP3 levels in mycosis fungoides-Cutaneous T-cell lymphoma: Clinical implications

(2013) M. Alcántara-Hernández et al.   INTERNATIONAL JOURNAL OF CANCER

Role of hypoxia-inducible factor-1α expression in regulatory T cells on nasal polypogenesis

(2013) Jun Jin et al.   LARYNGOSCOPE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Intratumor Hypoxia Promotes Immune Tolerance by Inducing Regulatory T Cells via TGF-β1 in Gastric Cancer

(2013) Bin Deng et al.   PLoS One

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes

(2012) Jaime Darce et al.   IMMUNITY

HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis

(2012) Masaaki Higashiyama et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

(2011) Reiko Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Hypoxia Potentiates Glioma-Mediated Immunosuppression

(2011) Jun Wei et al.   PLoS One

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α

(2008) Jeremy Ben-Shoshan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY