Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 2, Pages 173
Publisher
MDPI AG
Online
2016-02-10
DOI
10.3390/ijms17020173
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways
- (2017) John P. Cogswell et al. JOURNAL OF ALZHEIMERS DISEASE
- Increased Total TAU But Not Amyloid-β42; in Cerebrospinal Fluid Correlates with Short-Term Memory Impairment in Alzheimer's Disease
- (2017) Yuh-Te Lin et al. JOURNAL OF ALZHEIMERS DISEASE
- Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease
- (2017) Ayelén Bulloj et al. JOURNAL OF ALZHEIMERS DISEASE
- Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer
- (2016) Chiara Ciardiello et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
- (2015) Marcel Kunadt et al. ACTA NEUROPATHOLOGICA
- Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study
- (2015) Massimo S. Fiandaca et al. Alzheimers & Dementia
- Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease
- (2015) Dimitrios Kapogiannis et al. FASEB JOURNAL
- Extracellular Vesicles in Alzheimer’s Disease: Friends or Foes? Focus on Aβ-Vesicle Interaction
- (2015) Pooja Joshi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Dysfunction of Platelet-derived Growth Factor Receptor α (PDGFRα) Represses the Production of Oligodendrocytes from Arylsulfatase A-deficient Multipotential Neural Precursor Cells
- (2015) Katarzyna C. Pituch et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exosomes as drug delivery vehicles for Parkinson's disease therapy
- (2015) Matthew J. Haney et al. JOURNAL OF CONTROLLED RELEASE
- Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease
- (2015) Edward J. Goetzl et al. NEUROLOGY
- Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease
- (2015) F. Wu et al. NEUROSCIENCE
- Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases
- (2015) Bradley M. Coleman et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Correction: MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease
- (2015) Sowmya V. Yelamanchili et al. PLoS Pathogens
- Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer’s Disease
- (2015) Inmaculada Lopez-Font et al. Frontiers in Neurology
- Autophagy in neuronal cells: general principles and physiological and pathological functions
- (2014) Markus Damme et al. ACTA NEUROPATHOLOGICA
- Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease
- (2014) Min Shi et al. ACTA NEUROPATHOLOGICA
- CIRCULATING AND INTRATHECAL MIRNAS AS POTENTIAL BIOMARKERS FOR ALZHEIMER'S DISEASE
- (2014) Daniela Galimberti et al. Alzheimers & Dementia
- Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
- (2014) Anne-Maria Poehler et al. Autophagy
- A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide
- (2014) Kohei Yuyama et al. FEBS LETTERS
- Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
- (2014) Stephanie M.Y. Kong et al. HUMAN MOLECULAR GENETICS
- Acceleration of α-Synuclein Aggregation by Exosomes
- (2014) Marie Grey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice
- (2014) Kohei Yuyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ATP13A2/PARK9 Regulates Secretion of Exosomes and -Synuclein
- (2014) T. Tsunemi et al. JOURNAL OF NEUROSCIENCE
- Emerging Roles of Extracellular Vesicles in the Nervous System
- (2014) L. Rajendran et al. JOURNAL OF NEUROSCIENCE
- Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset
- (2014) Davide Chiasserini et al. Journal of Proteomics
- Prognostic serum miRNA biomarkers associated with Alzheimer’s disease shows concordance with neuropsychological and neuroimaging assessment
- (2014) L Cheng et al. MOLECULAR PSYCHIATRY
- Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice
- (2014) J. Mark Cooper et al. MOVEMENT DISORDERS
- Plasma phospholipids identify antecedent memory impairment in older adults
- (2014) Mark Mapstone et al. NATURE MEDICINE
- Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
- (2014) Michael B. Dinkins et al. NEUROBIOLOGY OF AGING
- Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance
- (2014) Jakob Domert et al. NEUROBIOLOGY OF DISEASE
- Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation
- (2014) D. Frohlich et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid
- (2014) Joshua HK Tam et al. Molecular Brain
- Increased DJ-1 in Urine Exosome of Korean Males with Parkinson’s Disease
- (2014) Dong Hwan Ho et al. Biomed Research International
- Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders
- (2014) Sarah van Veen et al. Frontiers in Molecular Neuroscience
- Exosomes and Autophagy: Coordinated Mechanisms for the Maintenance of Cellular Fitness
- (2014) Francesc Baixauli et al. Frontiers in Immunology
- Circulating miRNA biomarkers for Alzheimer's disease
- (2013) Pavan Kumar et al. Alzheimers & Dementia
- MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma
- (2013) Lynn M. Bekris et al. BIOMARKERS
- Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
- (2013) A. Bronisz et al. CANCER RESEARCH
- Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles
- (2013) P Joshi et al. CELL DEATH AND DIFFERENTIATION
- OVERLAPPING MOLECULAR SIGNATURES IN PARKINSON'S PATIENT LEUKOCYTES BEFORE AND AFTER TREATMENT AND IN MOUSE MODEL BRAIN REGIONS
- (2013) L Soreq et al. CNS & Neurological Disorders-Drug Targets
- LRRK2 secretion in exosomes is regulated by 14-3-3
- (2013) K. B. Fraser et al. HUMAN MOLECULAR GENETICS
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mind the gut: secretion of α-synuclein by enteric neurons
- (2013) Stefan A. Grathwohl et al. JOURNAL OF NEUROCHEMISTRY
- Profile of microRNAs in the plasma of Parkinson’s disease patients and healthy controls
- (2013) Lucía F. Cardo et al. JOURNAL OF NEUROLOGY
- Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine
- (2013) Lesley Cheng et al. KIDNEY INTERNATIONAL
- Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
- (2013) Victor L Villemagne et al. LANCET NEUROLOGY
- Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
- (2013) Mathias Jucker et al. NATURE
- Cerebrospinal fluid biomarkers in Parkinson disease
- (2013) Lucilla Parnetti et al. Nature Reviews Neurology
- Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity
- (2013) Katerina Melachroinou et al. NEUROBIOLOGY OF AGING
- Differential Expression of Exosomal microRNAs in Prefrontal Cortices of Schizophrenia and Bipolar Disorder Patients
- (2013) Meredith G. Banigan et al. PLoS One
- The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer
- (2013) Jordan Follett et al. TRAFFIC
- Extracellular vesicles as mediators of neuron-glia communication
- (2013) Carsten Frühbeis et al. Frontiers in Cellular Neuroscience
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo
- (2013) Kyongman An et al. Molecular Brain
- A blood based 12-miRNA signature of Alzheimer disease patients
- (2013) Petra Leidinger et al. GENOME BIOLOGY
- Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)
- (2012) Guanghu Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space
- (2012) Rocio Perez-Gonzalez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
- (2012) Kohei Yuyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activity-dependent secretion of alpha-synuclein by enteric neurons
- (2012) Sébastien Paillusson et al. JOURNAL OF NEUROCHEMISTRY
- Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of -Amyloid
- (2012) S. Nath et al. JOURNAL OF NEUROSCIENCE
- Identification and proteomic profiling of exosomes in human cerebrospinal fluid
- (2012) Jonathan M Street et al. Journal of Translational Medicine
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Constitutive secretion of tau protein by an unconventional mechanism
- (2012) Xiyun Chai et al. NEUROBIOLOGY OF DISEASE
- Trans-Synaptic Spread of Tau Pathology In Vivo
- (2012) Li Liu et al. PLoS One
- The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes
- (2012) Alessia Gallo et al. PLoS One
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
- (2012) Francisco Pan-Montojo et al. Scientific Reports
- Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease
- (2012) Valérie Vingtdeux et al. Frontiers in Physiology
- Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?
- (2012) Shayne A. Bellingham et al. Frontiers in Physiology
- The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain
- (2011) Tsuyoshi Hamaguchi et al. ACTA NEUROPATHOLOGICA
- Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
- (2011) Diana Simón et al. FEBS LETTERS
- MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
- (2011) Elena Miñones-Moyano et al. HUMAN MOLECULAR GENETICS
- Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
- (2011) Jing L. Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease
- (2011) Sudad Saman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of blood microRNAs associated to Parkinsońs disease
- (2011) Regina Margis et al. JOURNAL OF BIOTECHNOLOGY
- Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
- (2011) D. Fitzner et al. JOURNAL OF CELL SCIENCE
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
- (2011) Lydia Alvarez-Erviti et al. NATURE BIOTECHNOLOGY
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein
- (2011) Takafumi Hasegawa et al. PLoS One
- Convergence of miRNA Expression Profiling, α-Synuclein Interacton and GWAS in Parkinson's Disease
- (2011) Madalena Martins et al. PLoS One
- Patterns of microRNA expression in normal and early Alzheimer’s disease human temporal cortex: white matter versus gray matter
- (2010) Wang-Xia Wang et al. ACTA NEUROPATHOLOGICA
- Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
- (2010) Antonella Caccamo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- Peripherally Applied A -Containing Inoculates Induce Cerebral -Amyloidosis
- (2010) Y. S. Eisele et al. SCIENCE
- Propagation of Tau Misfolding from the Outside to the Inside of a Cell
- (2009) Bess Frost et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
- (2009) X. Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
- (2008) Robyn A. Sharples et al. FASEB JOURNAL
- Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
- (2008) Johan Skog et al. NATURE CELL BIOLOGY
- Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid
- (2008) Laura J. Vella et al. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
- The L1 cell adhesion molecule is a potential biomarker of human distal nephron injury in acute tubular necrosis
- (2007) Y. Allory et al. KIDNEY INTERNATIONAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started