Clearance of Amyloid Beta and Tau in Alzheimer’s Disease: from Mechanisms to Therapy

Chronic deep brain stimulation in an Alzheimer's disease mouse model enhances memory and reduces pathological hallmarks

(2018) Amandeep Mann et al.   Brain Stimulation

Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice

(2018) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

A Possible Role for CSF Turnover and Choroid Plexus in the Pathogenesis of Late Onset Alzheimer's Disease

(2018) Jean-Marie Serot et al.   JOURNAL OF ALZHEIMERS DISEASE

Transthyretin Stabilization by Iododiflunisal Promotes Amyloid-β Peptide Clearance, Decreases its Deposition, and Ameliorates Cognitive Deficits in an Alzheimer's Disease Mouse Model

(2018) Carlos A. Ribeiro et al.   JOURNAL OF ALZHEIMERS DISEASE

Biomarkers for Preclinical Alzheimer's Disease

(2018) Chen-Chen Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

(2016) Alan W. J. Morris et al.   ACTA NEUROPATHOLOGICA

Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme

(2016) Marcus O.W. Grimm et al.   Biochemistry and Cell Biology

Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer,s Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?

(2016) José Joaquín Merino et al.   Current Alzheimer Research

Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways

(2016) Naoki Yamamoto et al.   GLIA

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer’s Disease

(2016) Brittany N. Dugger et al.   JOURNAL OF ALZHEIMERS DISEASE

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide

(2016) Miriam Ries et al.   Journal of Neuroinflammation

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

(2016) Nobutaka Sakae et al.   JOURNAL OF NEUROSCIENCE

A 40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway

(2016) A. M. S. Hartz et al.   JOURNAL OF NEUROSCIENCE

CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

(2016) Bob Olsson et al.   LANCET NEUROLOGY

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease

(2016) Kaitlin M. Moore et al.   NEUROBIOLOGY OF DISEASE

Late running is not too late against Alzheimer's pathology

(2016) Arne Herring et al.   NEUROBIOLOGY OF DISEASE

1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport

(2016) Y.-X. Guo et al.   NEUROSCIENCE

Copper Exposure Perturbs Brain Inflammatory Responses and Impairs Clearance of Amyloid-Beta

(2016) Masashi Kitazawa et al.   TOXICOLOGICAL SCIENCES

Electroacupuncture improves memory and protects neurons by regulation of the autophagy pathway in a rat model of Alzheimer’s disease

(2016) Hai-dong Guo et al.   Acupuncture in Medicine

Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats

(2015) Loqman A. Mohamed et al.   ACS Chemical Neuroscience

Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model

(2015) Hisham Qosa et al.   ACS Chemical Neuroscience

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

(2015) Yang Xiang et al.   ACTA NEUROPATHOLOGICA

The binding of Aβ1–42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease

(2015) Michio Hashimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

(2015) Ekaterina G. Kochkina et al.   BIOGERONTOLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

(2015) Yi-dan Zhang et al.   DNA AND CELL BIOLOGY

Specific Amyloid β Clearance by a Catalytic Antibody Construct

(2015) Stephanie A. Planque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral macrophages not ADept at amyloid clearance

(2015) Taylor Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies

(2015) Maxime Hallé et al.   JOURNAL OF IMMUNOLOGICAL METHODS

NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons

(2015) Wenhui Fan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System

(2015) B. A. Plog et al.   JOURNAL OF NEUROSCIENCE

Prenatal high-fat diet alters the cerebrovasculature and clearance ofβ-amyloid in adult offspring

(2015) Cheryl A Hawkes et al.   JOURNAL OF PATHOLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease

(2015) Megan M. Varnum et al.   NEUROBIOLOGY OF AGING

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations

(2015) Catherine Chiu et al.   NEUROBIOLOGY OF AGING

Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of rapamycin: potential drug to treat Alzheimer’s disease

(2015) Yuyou Zhu et al.   NEUROLOGICAL SCIENCES

Minocycline attenuates Aβ oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aβ fibrils phagocytosis

(2015) Ismail Amr El-Shimy et al.   NEUROSCIENCE LETTERS

Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons

(2015) Adrianne S. Chesser et al.   NUTRITIONAL NEUROSCIENCE

Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer’s disease

(2015) Ibrahim González-Marrero et al.   Frontiers in Cellular Neuroscience

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

(2015) Wenjie Luo et al.   Scientific Reports

Reduced CSF Water Influx in Alzheimer’s Disease Supporting the β-Amyloid Clearance Hypothesis

(2015) Yuji Suzuki et al.   PLoS One

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Failure of Perivascular Drainage of β-amyloid in Cerebral Amyloid Angiopathy

(2014) Cheryl A. Hawkes et al.   BRAIN PATHOLOGY

Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells

(2014) Hironori Fujiwara et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Microglial Aβ Receptors in Alzheimer’s Disease

(2014) Yang Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

(2014) V. A. Polito et al.   EMBO Molecular Medicine

A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease

(2014) Yukiko Hori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association Between Polymorphisms of the Insulin-Degrading Enzyme Gene and Late-Onset Alzheimer Disease

(2014) Shitao Wang et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

(2014) Ting-Ting Chu et al.   Molecular BioSystems

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

ABCA7 in Alzheimer’s Disease

(2014) Qing-Fei Zhao et al.   MOLECULAR NEUROBIOLOGY

The Role of PICALM in Alzheimer’s Disease

(2014) Wei Xu et al.   MOLECULAR NEUROBIOLOGY

Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

(2014) Teng Jiang et al.   NEUROPHARMACOLOGY

Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

(2014) Teng Jiang et al.   NEUROPSYCHOPHARMACOLOGY

Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease

(2014) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Granulocyte-Colony Stimulating Factor Attenuates Oligomeric Amyloid β Neurotoxicity by Activation of Neprilysin

(2014) Yukiko Doi et al.   PLoS One

The role of protein clearance mechanisms in organismal ageing and age-related diseases

(2014) David Vilchez et al.   Nature Communications

Microglia in Alzheimer’s Disease

(2014) Ying Li et al.   Biomed Research International

Matrix Metalloproteinases and Their Multiple Roles in Alzheimer’s Disease

(2014) Xiang-Xiang Wang et al.   Biomed Research International

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

(2014) Takakuni Maki et al.   Annals of Clinical and Translational Neurology

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β

(2013) Simon J. Henderson et al.   BRAIN

Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease

(2013) Michelle A Erickson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

‘Hit & Run’ Model of Closed-Skull Traumatic Brain Injury (TBI) Reveals Complex Patterns of Post-Traumatic AQP4 Dysregulation

(2013) Zeguang Ren et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Ginsenoside Rg1 Decreases Neurofibrillary Tangles Accumulation in Retina by Regulating Activities of Neprilysin and PKA in Retinal Cells of AD Mice Model

(2013) Yanhui He et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice

(2013) Jing Du et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

TREM2 in Alzheimer’s disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

CD33 in Alzheimer's Disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy

(2013) Chen-Chen Tan et al.   NEUROBIOLOGY OF AGING

Sleep Facilitates Clearance of Metabolites from the Brain: Glymphatic Function in Aging and Neurodegenerative Diseases

(2013) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Is There a Cerebral Lymphatic System?

(2013) J. J. Iliff et al.   STROKE

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease

(2013) Adrianne S. Chesser et al.   Frontiers in Neurology

Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer’s disease

(2013) Roxana Carare et al.   Acta Neuropathologica Communications

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Human Serum Albumin Can Regulate Amyloid-β Peptide Fiber Growth in the Brain Interstitium

(2012) Helen F. Stanyon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

(2012) Amandine Magnaudeix et al.   NEUROBIOLOGY OF AGING

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

Mutant ubiquitin decreases amyloid β plaque formation in a transgenic mouse model of Alzheimer’s disease

(2012) Paula van Tijn et al.   NEUROCHEMISTRY INTERNATIONAL

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

Somatostatin Modulates Insulin-Degrading-Enzyme Metabolism: Implications for the Regulation of Microglia Activity in AD

(2012) Grazia Tundo et al.   PLoS One

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Blood–brain barrier P-glycoprotein function in Alzheimer's disease

(2011) Daniëlle M. E. van Assema et al.   BRAIN

A small-molecule enhancer of autophagy decreases levels of Aβ and APP-CTF via Atg5-dependent autophagy pathway

(2011) Yuan Tian et al.   FASEB JOURNAL

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier

(2011) Masachika Fujiyoshi et al.   JOURNAL OF NEUROCHEMISTRY

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

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(2011) Adriana Ferreira et al.   MOLECULAR MEDICINE

Autophagic degradation of tau in primary neurons and its enhancement by trehalose

(2011) Ulrike Krüger et al.   NEUROBIOLOGY OF AGING

Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-ß Peptide

(2011) Konstantin Glebov et al.   Neurodegenerative Diseases

Ubiquitin Enzymes, Ubiquitin and Proteasome Activity in Blood Mononuclear Cells of MCI, Alzheimer and Parkinson Patients

(2010) C. Ullrich et al.   Current Alzheimer Research

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

Ubiquitin-independent degradation of proteins by the proteasome

(2008) Isabelle Jariel-Encontre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice

(2008) Brian Spencer et al.   BMC NEUROSCIENCE