Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways

Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy

(2017) Yichao Zhao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis

(2017) Hao Zhou et al.   JOURNAL OF PINEAL RESEARCH

Randomized Trial Comparing the Effects of Ticagrelor Versus Clopidogrel on Myocardial Perfusion in Patients With Coronary Artery Disease

(2017) Matthieu Pelletier‐Galarneau et al.   Journal of the American Heart Association

Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening

(2017) Hao Zhou et al.   Journal of the American Heart Association

Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study

(2017) Sining Hu et al.   Journal of the American Heart Association

HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases

(2017) Po-Hsiung Kung et al.   Redox Biology

DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression

(2017) Maceler Aldrovandi et al.   Redox Biology

Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

(2017) Heather M. Wilkins et al.   Redox Biology

Mitochondria-meditated pathways of organ failure upon inflammation

(2017) Andrey V. Kozlov et al.   Redox Biology

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Platelets and coronary artery disease: Interactions with the blood vessel wall and cardiovascular devices

(2016) Markus Reinthaler et al.   Biointerphases

Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism

(2016) Saranya Ravi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca2+–XO–ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways

(2016) Ying Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin attenuated adipogenesis through reduction of the CCAAT/enhancer binding protein beta by regulating the glycogen synthase 3 beta in human mesenchymal stem cells

(2016) Yun-Hee Rhee et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy

(2016) Chao Lin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner

(2016) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents the dynamin-related protein 1-dependent mitochondrial fission and oxidative insult in the cortical neurons after 1-methyl-4-phenylpyridinium treatment

(2016) Jih-Ing Chuang et al.   JOURNAL OF PINEAL RESEARCH

Effect of intravenous and intracoronary melatonin as an adjunct to primary percutaneous coronary intervention for acute ST-elevation myocardial infarction: Results of the Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty trial

(2016) Alberto Dominguez-Rodriguez et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression

(2016) Hai-Feng Pei et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1

(2016) Jianqiang Hu et al.   JOURNAL OF PINEAL RESEARCH

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats

(2016) Karolina Siewiera et al.   LIFE SCIENCES

PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation

(2016) Wei Zou et al.   NATURE MEDICINE

Platelets and coronary artery disease: Interactions with the blood vessel wall and cardiovascular devices

(2016) Markus Reinthaler et al.   Biointerphases

Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

(2016) Weilin Zhang et al.   eLife

Nanoparticle‐Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia‐Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction

(2016) Ayako Ishikita et al.   Journal of the American Heart Association

Relationship of Platelet Reactivity With Bleeding Outcomes During Long‐Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non‐ST‐Segment Elevation Acute Coronary Syndromes

(2016) Jan H. Cornel et al.   Journal of the American Heart Association

Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation

(2016) Shabnam Salimi et al.   Journal of the American Heart Association

Relationship Between Arterial Access and Outcomes in ST‐Elevation Myocardial Infarction With a Pharmacoinvasive Versus Primary Percutaneous Coronary Intervention Strategy: Insights From the STrategic Reperfusion Early After Myocardial Infarction (STREAM) Study

(2016) Jay Shavadia et al.   Journal of the American Heart Association

Universal Classification System Type of Incident Myocardial Infarction in Patients With Stable Atherosclerosis: Observations From Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2°P)‐TIMI 50

(2016) Stephen K. Kidd et al.   Journal of the American Heart Association

Detecting presence of cardiovascular disease through mitochondria respiration as depicted through biophotonic emission

(2016) Nancy R. Rizzo et al.   Redox Biology

Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial

(2016) Sanne Tofte Rasmussen et al.   Redox Biology

The role of the autophagy in myocardial ischemia/reperfusion injury

(2015) Sai Ma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol inhibits collagen-induced platelet stimulation through suppressing NADPH oxidase and oxidative inactivation of SH2 domain-containing protein tyrosine phosphatase-2

(2015) Ji Yong Jang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of melatonin on lipopolysaccharide-induced mastitis in mice

(2015) Guoxi Shao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Melatonin rescues cardiovascular dysfunction during hypoxic development in the chick embryo

(2015) Nozomi Itani et al.   JOURNAL OF PINEAL RESEARCH

Role of toll-like receptor 4 in melatonin-induced cardioprotection

(2015) Frederic Nduhirabandi et al.   JOURNAL OF PINEAL RESEARCH

Melatonin facilitates adipose-derived mesenchymal stem cells to repair the murine infarcted heartviathe SIRT1 signaling pathway

(2015) Dong Han et al.   JOURNAL OF PINEAL RESEARCH

Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice

(2015) Sandra Barbosa-da-Silva et al.   LIFE SCIENCES

Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived factor-1α/CXC chemokine receptor 4 pathway

(2015) HAO ZHOU et al.   Molecular Medicine Reports

Metformin reduces hyper-reactivity of platelets from patients with polycystic ovary syndrome by improving mitochondrial integrity

(2015) Amro Elgheznawy et al.   THROMBOSIS AND HAEMOSTASIS

Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro

(2015) Hao Zhou et al.   Scientific Reports

Atherosclerotic Plaque Morphology Indicates Clinical Symptoms of Plaque Progression

(2014) Tian Feng et al.   CARDIOLOGY

ST elevation acute myocardial infarction accelerates non-culprit coronary lesion atherosclerosis

(2014) Yunfeng Han et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets

(2014) M.-B. Onselaer et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Melatonin elevates apoptosis in human platelets via ROS mediated mitochondrial damage

(2013) Kesturu Subbaiah Girish et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antiplatelet effect of AMP-activated protein kinase activator and its potentiation by the phosphodiesterase inhibitor dipyridamole

(2013) Yingqiu Liu et al.   BIOCHEMICAL PHARMACOLOGY

Characterization of culprit lesions in acute coronary syndromes compared with stable angina pectoris by dual-source computed tomography

(2012) Xia Yang et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Phosphorylation of Vasodilator-Stimulated Phosphoprotein Prevents Platelet-Neutrophil Complex Formation and Dampens Myocardial Ischemia-Reperfusion Injury

(2011) David Köhler et al.   CIRCULATION

Expression of melatonin in platelets of patients with aspirin-induced asthma

(2011) Helen V. Evsyukova   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

PPARβ/δ Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association/Repression of PKCα–Brief Report

(2009) Ferhana Y. Ali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The platelet as a model system for the acute actions of nuclear receptors

(2009) David Bishop-Bailey   STEROIDS

Rosiglitazone produces a greater reduction in circulating platelet activity compared with gliclazide in patients with type 2 diabetes mellitus—An effect probably mediated by direct platelet PPARγ activation

(2007) M.P. Khanolkar et al.   ATHEROSCLEROSIS