Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice by reducing brain β-amyloid through PPARγ activation

PPARγ Agonist Pioglitazone Reverses Memory Impairment and Biochemical Changes in a Mouse Model of Type 2 Diabetes Mellitus

(2012) Li-Ying Jiang et al.   CNS Neuroscience & Therapeutics

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear receptors as therapeutic targets for Alzheimer's disease

(2011) Shweta Mandrekar-Colucci et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Verbal and academic skills in children with early-onset type 1 diabetes

(2010) RIITTA HANNONEN et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Increased expression of β amyloid precursor gene in the hippocampus of streptozotocin-induced diabetic mice with memory deficit and anxiety induction

(2010) Sung Wook Jung et al.   JOURNAL OF NEURAL TRANSMISSION

How does diabetes accelerate Alzheimer disease pathology?

(2010) Catrina Sims-Robinson et al.   Nature Reviews Neurology

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

(2010) Michela Guglielmotto et al.   NEUROBIOLOGY OF AGING

Linking type 2 diabetes and Alzheimer's disease

(2010) W. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and A  deposition in an Alzheimer mouse model with diabetes

(2010) S. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear receptor PPARγ as a therapeutic target for cerebrovascular and brain dysfunction in Alzheimer's disease

(2010) Nektaria Nicolakakis   Frontiers in Aging Neuroscience

Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice

(2009) Corinne G. Jolivalt et al.   EXPERIMENTAL NEUROLOGY

Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus

(2009) Tony Valente et al.   NEUROBIOLOGY OF DISEASE

Downregulation of LPR1 at the blood–brain barrier in streptozotocin-induced diabetic mice

(2009) Hao Hong et al.   NEUROPHARMACOLOGY

Upregulation of RAGE at the blood-brain barrier in streptozotocin-induced diabetic mice

(2009) Li Ping Liu et al.   SYNAPSE

A look inside the diabetic brain: Contributors to diabetes-induced brain aging

(2008) Shayna A. Wrighten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cognitive Dysfunction and Diabetes Mellitus

(2008) Christopher T. Kodl et al.   ENDOCRINE REVIEWS

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

Increased amyloid β-peptide (1–40) level in brain of streptozotocin-induced diabetic rats

(2008) Y. Liu et al.   NEUROSCIENCE