Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

Sirt1 restrains lung inflammasome activation in a murine model of sepsis

(2015) Rong Gao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice

(2015) Anding Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis

(2015) Ali H. Amin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of isoproterenol-induced cardiac mitochondrial damage: protective actions of melatonin

(2015) Debasri Mukherjee et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a treatment for gastrointestinal cancer: a review

(2015) Zhenlong Xin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

(2015) Jia-Yi Wei et al.   JOURNAL OF PINEAL RESEARCH

Simvastatin attenuates sepsis-induced blood-brain barrier integrity loss

(2015) Chen-Hsien Yang et al.   JOURNAL OF SURGICAL RESEARCH

A novel synthetic derivative of melatonin, 5-hydroxy-2’-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation

(2015) Do-Wan Shim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

SIRT1 in the brain—connections with aging-associated disorders and lifespan

(2015) Fanny Ng   Frontiers in Cellular Neuroscience

The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation

(2015) Juhyun Song et al.   Biomed Research International

Melatonin protects against behavioural dysfunctions and dendritic spine damage in 3-nitropropionic acid-induced rat model of Huntington's disease

(2014) J. Chakraborty et al.   BEHAVIOURAL BRAIN RESEARCH

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

(2014) Lingling Liu et al.   BRAIN RESEARCH

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose

(2014) T.-Y. Song et al.   FREE RADICAL RESEARCH

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury

(2014) Hong-Hwa Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology

(2014) Stefano Comai et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against bisphenol-A-induced apoptosis

(2014) Mohamed A. El-Missiry et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation

(2014) Chae-Hwa Yoo et al.   Scientific Reports

Effect of Melatonin on Intracranial Pressure and Brain Edema Following Traumatic Brain Injury: Role of Oxidative Stresses

(2013) Fatemeh Dehghan et al.   ARCHIVES OF MEDICAL RESEARCH

Novel Role of Silent Information Regulator 1 in Myocardial Ischemia

(2013) Yang Yang et al.   CIRCULATION

Role of Microglia in the Pathogenesis of Sepsis-Associated Encephalopathy

(2013) Y.Y. Deng et al.   CNS & Neurological Disorders-Drug Targets

A novel melatonin agonist Neu-P11 facilitates memory performance and improves cognitive impairment in a rat model of Alzheimer' disease

(2013) Pingping He et al.   HORMONES AND BEHAVIOR

JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

(2013) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Sepsis-induced changes in behavioral stereotypy in rats; involvement of tumor necrosis factor-alpha, oxidative stress, and dopamine turnover

(2013) Oytun Erbaş et al.   JOURNAL OF SURGICAL RESEARCH

Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage

(2013) M. Hernandez-Jimenez et al.   STROKE

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury

(2012) Hongmin Zhang et al.   JOURNAL OF PINEAL RESEARCH

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Resveratrol Attenuates Ischemia/Reperfusion Injury in Neonatal Cardiomyocytes and Its Underlying Mechanism

(2012) Min Shen et al.   PLoS One

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

Melatonin in septic shock: Some recent concepts

(2010) Venkataramanujan Srinivasan et al.   JOURNAL OF CRITICAL CARE

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

(2009) Merce Pallas et al.   CURRENT NEUROVASCULAR RESEARCH

Pathogenesis of septic encephalopathy

(2009) Peter Pytel et al.   CURRENT OPINION IN NEUROLOGY

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

(2009) Hung-Ming Chang et al.   JOURNAL OF PINEAL RESEARCH

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway

(2009) M. Tajes et al.   JOURNAL OF PINEAL RESEARCH

Oxidative Mechanisms of Brain Dysfunction During Sepsis

(2009) Felipe Dal-Pizzol et al.   NEUROCHEMICAL RESEARCH

SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization

(2008) Myung-Kwan Han et al.   Cell Stem Cell

Building a continuous multicenter infection surveillance system in the intensive care unit: Findings from the initial data set of 9,493 patients from 71 Italian intensive care units

(2008) Paolo Malacarne et al.   CRITICAL CARE MEDICINE

Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats

(2008) Jeng-Yuan Wu et al.   JOURNAL OF PINEAL RESEARCH

Injury of the Blood Brain Barrier and Up-Regulation of ICAM-1 in Polymicrobial Sepsis

(2007) Stefan Hofer et al.   JOURNAL OF SURGICAL RESEARCH

TNF is a key mediator of septic encephalopathy acting through its receptor, TNF receptor-1

(2007) Jessy J. Alexander et al.   NEUROCHEMISTRY INTERNATIONAL