Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

Constant Illumination Induces Alzheimer-Like Damages with Endoplasmic Reticulum Involvement and the Protection of Melatonin

(2017) Zhi-Qun Ling et al.   JOURNAL OF ALZHEIMERS DISEASE

Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells

(2015) Alejandro Romero et al.   JOURNAL OF PINEAL RESEARCH

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

2011 Alzheimer’s disease facts and figures

(2011)   Alzheimers & Dementia

On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals

(2011) Annia Galano   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo

(2010) Jin Chu et al.   ANNALS OF NEUROLOGY

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neurotoxins: Free Radical Mechanisms and Melatonin Protection

(2010) Russel J. Reiter et al.   Current Neuropharmacology

Mitochondrial Dynamics in Alzheimerʼs Disease

(2010) David J. Bonda et al.   DRUGS & AGING

Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain

(2010) Ethika Tyagi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin agonists and insomnia

(2010) Sally A Ferguson et al.   Expert Review of Neurotherapeutics

Amyloid oligomers: formation and toxicity of Aβ oligomers

(2010) Masafumi Sakono et al.   FEBS Journal

Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

(2010) M.A. Bradley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Genetic Dissection of the Amyloid Precursor Protein in Developmental Function and Amyloid Pathogenesis

(2010) Hongmei Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells

(2010) Lars-Ove Brandenburg et al.   JOURNAL OF NEUROCHEMISTRY

Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice

(2010) Sida Niu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone

(2010) Areechun Sotthibundhu et al.   JOURNAL OF PINEAL RESEARCH

Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder

(2010) Piotr Gałecki et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

(2010) Giuseppe Paradies et al.   JOURNAL OF PINEAL RESEARCH

Melatonin treatment normalizes plasma pro-inflammatory cytokines and nitrosative/oxidative stress in patients suffering from Duchenne muscular dystrophy

(2010) Mariam Chahbouni et al.   JOURNAL OF PINEAL RESEARCH

Long-term enteral administration of melatonin reduces plasma insulin and increases expression of pineal insulin receptors in both Wistar and type 2-diabetic Goto-Kakizaki rats

(2010) Elmar Peschke et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats

(2010) Kyung Hee Jung et al.   JOURNAL OF PINEAL RESEARCH

Amyloid-β neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3β,tauand neuroinflammation

(2010) Juliana Bender Hoppe et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A

(2010) Xifei Yang et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

(2010) Pil-Jae Kong et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Choroid plexus portals and a deficiency of melatonin can explain the neuropathology of Alzheimer’s disease

(2010) Charles P. Maurizi   MEDICAL HYPOTHESES

Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

(2010) Xu Wang et al.   Molecular Neurodegeneration

Current Treatment and Recent Clinical Research in Alzheimer's Disease

(2010) Judith Neugroschl et al.   MOUNT SINAI JOURNAL OF MEDICINE

Investigation into the efficacy of the acetylcholinesterase inhibitor, donepezil, and novel procognitive agents to induce gamma oscillations in rat hippocampal slices

(2010) J.P. Spencer et al.   NEUROPHARMACOLOGY

Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid β-protein

(2010) Kohei Yuyama et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan

(2010) Burkhard Poeggeler et al.   PLoS One

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

NOX Enzymes in the Central Nervous System: From Signaling to Disease

(2009) Silvia Sorce et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional Aspects of Redox Control During Neuroinflammation

(2009) Sergio Rosales-Corral et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid β-Peptide Directly Induces Spontaneous Calcium Transients, Delayed Intercellular Calcium Waves and Gliosis in Rat Cortical Astrocytes

(2009) Siu-Kei Chow et al.   ASN Neuro

Inhibitors of protein aggregation and toxicity

(2009) Hozefa Amijee et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration

(2009) Ming-Jen Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Melatonin and Reproduction Revisited

(2009) Russel J. Reiter et al.   BIOLOGY OF REPRODUCTION

Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi

(2009) Raj Kamal Srivastava et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

(2009) Russel J. Reiter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Melatonin Improves Glucose Homeostasis and Endothelial Vascular Function in High-Fat Diet-Fed Insulin-Resistant Mice

(2009) Claudio Sartori et al.   ENDOCRINOLOGY

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Alzheimer's disease mitochondrial cascade hypothesis: An update

(2009) Russell H. Swerdlow et al.   EXPERIMENTAL NEUROLOGY

Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide

(2009) Xin Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release

(2009) Giuseppe Petrosillo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of glutamate and its receptors and insulin-like growth factors in hypoxia induced periventricular white matter injury

(2009) Viswanathan Sivakumar et al.   GLIA

Molecular Mechanisms of Melatonin Anticancer Effects

(2009) Steven M. Hill et al.   INTEGRATIVE CANCER THERAPIES

Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease

(2009) Gjumrakch Aliev et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Is there a primary role of the mitochondrial genome in Alzheimer’s disease?

(2009) Michelangelo Mancuso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Increased Membrane Cholesterol Might Render Mature Hippocampal Neurons More Susceptible to  -Amyloid-Induced Calpain Activation and Tau Toxicity

(2009) A. M. Nicholson et al.   JOURNAL OF NEUROSCIENCE

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model

(2009) Victor Tapias et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Altered Brain Serotonin Transporter and Associated Glucose Metabolism in Alzheimer Disease

(2009) Y. Ouchi et al.   JOURNAL OF NUCLEAR MEDICINE

An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis

(2009) Marta Tajes Orduña et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells

(2009) Wilaiwan Wisessmith et al.   JOURNAL OF PINEAL RESEARCH

Long-term melatonin administration protects brain mitochondria from aging

(2009) Miguel Carretero et al.   JOURNAL OF PINEAL RESEARCH

Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease

(2009) James M. Olcese et al.   JOURNAL OF PINEAL RESEARCH

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

(2009) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+-mediated permeability transition and beyond in rat brain astrocytes

(2009) Mei-Jie Jou et al.   JOURNAL OF PINEAL RESEARCH

Reactions of the melatonin metaboliteN1-acetyl-5-methoxykynuramine with carbamoyl phosphate and related compounds

(2009) Jana T. Kuesel et al.   JOURNAL OF PINEAL RESEARCH

Conformation and topology of amyloid β-protein adsorbed on a tethered artificial membrane probed by surface plasmon field-enhanced fluorescence spectroscopy

(2009) Haipeng Song et al.   JOURNAL OF STRUCTURAL BIOLOGY

The Insulin/Akt Signaling Pathway Is Targeted by Intracellular β-Amyloid

(2009) Han-Kyu Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort

(2009) J.C.S. Breitner et al.   NEUROLOGY

Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix–loop–helix transcription factors and cell cycle in neural stem cells

(2009) M. Katakura et al.   NEUROSCIENCE

A New Tacrine–Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease

(2009) Carlos Spuch et al.   NEUROTOXICITY RESEARCH

Melatonin Promotes Oligodendroglial Maturation of Injured White Matter in Neonatal Rats

(2009) Paul Olivier et al.   PLoS One

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease

(2009) C. A. Massaad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease

(2009) Tania García et al.   TOXICOLOGY

Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism

(2009) F. Radogna et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NADPH oxidase mediates β-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures

(2009) Faridis Serrano et al.   Molecular Brain

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

Catalytic Antioxidants and Neurodegeneration

(2008) Tamara R. Golden et al.   ANTIOXIDANTS & REDOX SIGNALING

Association of GSK3B With Alzheimer Disease and Frontotemporal Dementia

(2008) Barbara A. J. Schaffer et al.   ARCHIVES OF NEUROLOGY

Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice

(2008) Rahul Agrawal et al.   BEHAVIOURAL BRAIN RESEARCH

ROCK, PAK, and Toll of synapses in Alzheimer’s disease

(2008) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2

(2008) Barbara Calamini et al.   BIOCHEMICAL JOURNAL

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

(2008) Crystal M. Cordes et al.   BIOCHEMICAL PHARMACOLOGY

Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3β signaling pathways and changes in protein expression

(2008) Ana I. Duarte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

BACE1 Structure and Function in Health and Alzheimers Disease

(2008) Sarah Cole et al.   Current Alzheimer Research

Mitochondria, Mitochondrial DNA and Alzheimers Disease. What Comes First?

(2008) Michelangelo Mancuso et al.   Current Alzheimer Research

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

Functional Role of Lipoprotein Receptors in Alzheimers Disease

(2008) Claus Pietrzik et al.   Current Alzheimer Research

Cellular and Biochemical Actions of Melatonin which Protect Against Free Radicals: Role in Neurodegenerative Disorders

(2008) Genaro Ortiz et al.   Current Neuropharmacology

Melatonin: Quantum-chemical and biochemical investigation of antioxidant activity

(2008) Zhivko A. Velkov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

(2008) Rosa Resende et al.   FREE RADICAL BIOLOGY AND MEDICINE

The neuroprotective role of melatonin against amyloidβpeptide injected mice

(2008) J. Gunasingh Masilamoni et al.   FREE RADICAL RESEARCH

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

(2008) Tanea T. Reed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

(2008) Teresa F Pais et al.   Journal of Neuroinflammation

The oxidation products of melatonin derivatives exhibit acetylcholinesterase and butyrylcholinesterase inhibitory activity

(2008) Aleksandra Siwicka et al.   JOURNAL OF PINEAL RESEARCH

Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-β1-42

(2008) Juefei Zhou et al.   JOURNAL OF PINEAL RESEARCH

Cytoprotective effects of melatonin on C6 astroglial cells exposed to glutamate excitotoxicity and oxidative stress

(2008) Arabinda Das et al.   JOURNAL OF PINEAL RESEARCH

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

S100B/RAGE-dependent activation of microglia via NF-κB and AP-1

(2008) Roberta Bianchi et al.   NEUROBIOLOGY OF AGING

Hypercholesterolemia-induced Aβ accumulation in rabbit brain is associated with alteration in IGF-1 signaling

(2008) Sunita Sharma et al.   NEUROBIOLOGY OF DISEASE

Contribution of NMDA and Non-NMDA Receptors to In vivo Glutamate-Induced Calpain Activation in the Rat Striatum. Relation to Neuronal Damage

(2008) Perla Del Río et al.   NEUROCHEMICAL RESEARCH

Neurodegeneration and Inflammation

(2008) Mark H. DeLegge et al.   NUTRITION IN CLINICAL PRACTICE

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer’s disease

(2007) Omidreza Firuzi et al.   FASEB JOURNAL

Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid β-peptide

(2007) Rukhsana Sultana et al.   Molecular BioSystems

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE