Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

(2016) Johannes Schödel et al.   EUROPEAN UROLOGY

Impact of Obesity and Metabolic Syndrome on Immunity

(2016) Catherine J Andersen et al.   Advances in Nutrition

CD11c+macrophages and levels of TNF-α and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidaemia

(2015) K. Uchida et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Unicompartmental and bicompartmental knee osteoarthritis show different patterns of mononuclear cell infiltration and cytokine release in the affected joints

(2015) B. Moradi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9

(2015) G. Zhou et al.   DEVELOPMENT

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age

(2015) Kahaer Abula et al.   FEBS LETTERS

Dexamethasone inhibits chondrocyte differentiation by suppression of Wnt/β-catenin signaling in the chondrogenic cell line ATDC5

(2015) Masako Naito et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Aucubin prevents interleukin-1 beta induced inflammation and cartilage matrix degradation via inhibition of NF-κB signaling pathway in rat articular chondrocytes

(2015) Sheng-nan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Local delivery of mutant CCL2 protein-reduced orthopaedic implant wear particle-induced osteolysis and inflammation in vivo

(2015) Xinyi Jiang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Hypoxia-inducible factor 3-alpha expression is associated with the stable chondrocyte phenotype

(2015) Brandon D. Markway et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Subchondral bone turnover, but not bone volume, is increased in early stage osteoarthritic lesions in the human hip joint

(2015) R. Klose-Jensen et al.   OSTEOARTHRITIS AND CARTILAGE

Metabolic triggered inflammation in osteoarthritis

(2015) X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis

(2015) V. Silverwood et al.   OSTEOARTHRITIS AND CARTILAGE

Role of TGF-β Signaling in Remodeling of Noncoronary Artery Aneurysms in Kawasaki Disease

(2015) Aaron M. Lee et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Leukocyte integrins: Role in leukocyte recruitment and as therapeutic targets in inflammatory disease

(2015) Ioannis Mitroulis et al.   PHARMACOLOGY & THERAPEUTICS

Carnosol Inhibits Pro-Inflammatory and Catabolic Mediators of Cartilage Breakdown in Human Osteoarthritic Chondrocytes and Mediates Cross-Talk between Subchondral Bone Osteoblasts and Chondrocytes

(2015) Christelle Sanchez et al.   PLoS One

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

(2015) Erfan Aref-Eshghi et al.   ARTHRITIS RESEARCH & THERAPY

Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

(2015) Wafa Bouaziz et al.   ARTHRITIS RESEARCH & THERAPY

What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging-Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative

(2015) Frank W. Roemer et al.   Arthritis & Rheumatology

Components of the RANK/RANKL/OPG System, IL-6, IL-8, IL-16, MMP-2, and Calcitonin in the Sera of Patients with Bone Tumors

(2014) N. E. Kushlinskii et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Genomic Analysis and Differential Expression of HMG and S100A Family in Human Arthritis: Upregulated Expression of Chemokines, IL-8 and Nitric Oxide by HMGB1

(2014) Ashok R. Amin et al.   DNA AND CELL BIOLOGY

Cellular and molecular mechanisms of cartilage damage and repair

(2014) Joanna C. Sherwood et al.   DRUG DISCOVERY TODAY

Baicalein ameliorates inflammatory-related apoptotic and catabolic phenotypes in human chondrocytes

(2014) Xiaodong Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The multiple, complex roles of versican and its proteolytic turnover by ADAMTS proteases during embryogenesis

(2014) Sumeda Nandadasa et al.   MATRIX BIOLOGY

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

The responsiveness of novel, dynamic, contrast-enhanced magnetic resonance measures of total knee synovitis after intra-articular corticosteroid for painful osteoarthritis

(2014) C.Y.J. Wenham et al.   OSTEOARTHRITIS AND CARTILAGE

Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation state

(2014) N. Fahy et al.   OSTEOARTHRITIS AND CARTILAGE

Spatial regulation of gene expression during growth of articular cartilage in juvenile mice

(2014) Julian C. Lui et al.   PEDIATRIC RESEARCH

Effects of CD14 Macrophages and Proinflammatory Cytokines on Chondrogenesis in Osteoarthritic Synovium-Derived Stem Cells

(2014) Sun Ae Han et al.   TISSUE ENGINEERING PART A

Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts

(2014) Béatrice Bouvard et al.   ARTHRITIS RESEARCH & THERAPY

Low-density lipoprotein receptor–related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction

(2014) Youngnim Shin et al.   ARTHRITIS RESEARCH & THERAPY

Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice

(2014) Jingming Zhou et al.   ARTHRITIS RESEARCH & THERAPY

Infrapatellar fat pad in the knee: is local fat good or bad for knee osteoarthritis?

(2014) Weiyu Han et al.   ARTHRITIS RESEARCH & THERAPY

ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury

(2014) Kadir Demircan et al.   Biomed Research International

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

(2014) Gary J. Litherland et al.   Arthritis & Rheumatology

Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

(2014) Thomas Funck-Brentano et al.   Arthritis & Rheumatology

Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis

(2013) D A Binks et al.   ANNALS OF THE RHEUMATIC DISEASES

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues

(2013) Susan Y. Ritter et al.   ARTHRITIS AND RHEUMATISM

Wnt signaling is involved in human articular chondrocyte de-differentiation in vitro

(2013) N Sassi et al.   BIOTECHNIC & HISTOCHEMISTRY

Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation

(2013) Svitlana Golovchenko et al.   BONE

Parathyroid hormone-related protein is induced by hypoxia and promotes expression of the differentiated phenotype of human articular chondrocytes

(2013) Michele Pelosi et al.   CLINICAL SCIENCE

The burden of osteoarthritis: development and validation of a new assessment tool (BONe’S)

(2013) François Rannou et al.   CURRENT MEDICAL RESEARCH AND OPINION

The genetics and functional analysis of primary osteoarthritis susceptibility

(2013) Louise N. Reynard et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A current review of molecular mechanisms regarding osteoarthritis and pain

(2013) Andrew S. Lee et al.   GENE

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Epiphyseal Cartilage Development through β-Catenin-dependent and -independent Pathways

(2013) Xianrong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Syndrome in Rheumatoid Arthritis

(2013) Iván Ferraz-Amaro et al.   MEDIATORS OF INFLAMMATION

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Subchondral cyst development and MMP-1 expression during progression of osteoarthritis: An immunohistochemical study

(2013) A. Kaspiris et al.   Orthopaedics & Traumatology-Surgery & Research

Metatarsophalangeal joint pain in psoriatic arthritis: a cross-sectional study

(2013) D. E. Turner et al.   RHEUMATOLOGY

Defining and mapping the person with osteoarthritis for population studies and public health

(2013) E. Thomas et al.   RHEUMATOLOGY

Brief Report: Carboxypeptidase B Serves as a Protective Mediator in Osteoarthritis

(2013) Christin M. Lepus et al.   Arthritis & Rheumatology

Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis

(2012) Julie C. Baker-LePain et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis

(2012) Kayo Masuko et al.   International Journal of Rheumatic Diseases

Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling

(2012) Jonathan D. Holz et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Differential protein profiling of synovial fluid from rheumatoid arthritis and osteoarthritis patients using LC–MALDI TOF/TOF

(2012) Jesús Mateos et al.   Journal of Proteomics

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Retinal Muller Glia Initiate Innate Response to Infectious Stimuli via Toll-Like Receptor Signaling

(2012) Ashok Kumar et al.   PLoS One

Focus Issue: Wnt and  -Catenin Signaling in Development and Disease

(2012) N. R. Gough   Science Signaling

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

(2012) Liesbet Lodewyckx et al.   ARTHRITIS RESEARCH & THERAPY

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

(2011) Meina Wang et al.   Annals of the New York Academy of Sciences

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

RNA sensors in human osteoarthritis and rheumatoid arthritis synovial fibroblasts: Immune regulation by vasoactive intestinal peptide

(2011) Mar Carrión et al.   ARTHRITIS AND RHEUMATISM

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

The Effects of Adipokines on Cartilage and Meniscus Catabolism

(2011) Amy L. McNulty et al.   CONNECTIVE TISSUE RESEARCH

NC4 Domain of Cartilage-specific Collagen IX Inhibits Complement Directly Due to Attenuation of Membrane Attack Formation and Indirectly through Binding and Enhancing Activity of Complement Inhibitors C4B-binding Protein and Factor H

(2011) Nikolina Kalchishkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Associations of Anatomical Measures from MRI with Radiographically Defined Knee Osteoarthritis Score, Pain, and Physical Functioning

(2011) MaryFran Sowers et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Extracellular calcium chronically induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV

(2011) Elena Gabusi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities

(2011) Angela Moncada-Pazos et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Identification of a Panel of Novel Serum Osteoarthritis Biomarkers

(2011) Patricia Fernández-Puente et al.   JOURNAL OF PROTEOME RESEARCH

Expression of Toll-like Receptors and Their Signaling Pathways in Rheumatoid Synovitis

(2011) YASUNOBU TAMAKI et al.   JOURNAL OF RHEUMATOLOGY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

OARSI-FDA initiative: defining the disease state of osteoarthritis

(2011) N.E. Lane et al.   OSTEOARTHRITIS AND CARTILAGE

T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

(2011) P.-C. Shen et al.   OSTEOARTHRITIS AND CARTILAGE

Zonal differences in meniscus matrix turnover and cytokine response

(2011) E.S. Fuller et al.   OSTEOARTHRITIS AND CARTILAGE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis

(2011) Muneaki Ishijima et al.   ARTHRITIS RESEARCH & THERAPY

β-catenin, cartilage, and osteoarthritis

(2010) Qiuqian Wu et al.   Annals of the New York Academy of Sciences

Relation of synovitis to knee pain using contrast-enhanced MRIs

(2010) K. Baker et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage

(2010) Ann K. Rosenthal et al.   ARTHRITIS AND RHEUMATISM

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

HIF-2  Enhances  -Catenin/TCF-Driven Transcription by Interacting with  -Catenin

(2010) H. Choi et al.   CANCER RESEARCH

Emerging Ideas: Prevention of Posttraumatic Arthritis Through Interleukin-1 and Tumor Necrosis Factor-alpha Inhibition

(2010) J. Todd R. Lawrence et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Is Cartilage Matrix Breakdown an Appropriate Therapeutic Target in Osteoarthritis – Insights from Studies of Aggrecan and Collagen Proteolysis?

(2010) Christopher B. Little et al.   CURRENT DRUG TARGETS

Quantitative determination of the diagnostic accuracy of the synovitis score and its components

(2010) Elisabeth Slansky et al.   HISTOPATHOLOGY

Molecular mechanisms of cartilage remodelling in osteoarthritis

(2010) Jessica Bertrand et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Osteochondral plate angiogenesis: A new treatment target in osteoarthritis

(2010) Laurence Pesesse et al.   JOINT BONE SPINE

Chronic Inflammation in Obesity and the Metabolic Syndrome

(2010) Rosário Monteiro et al.   MEDIATORS OF INFLAMMATION

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

HIF-2α as a possible therapeutic target of osteoarthritis

(2010) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Vascular cell adhesion molecule 1 as a predictor of severe osteoarthritis of the hip and knee joints

(2009) Georg Schett et al.   ARTHRITIS AND RHEUMATISM

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The multicenter osteoarthritis study

(2009) Martin Englund et al.   ARTHRITIS AND RHEUMATISM

Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis

(2009) Kei Sakao et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease

(2009) C.R. Scanzello et al.   OSTEOARTHRITIS AND CARTILAGE

The Meniscus in Knee Osteoarthritis

(2009) Martin Englund et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy

(2008) C J Brew et al.   ANNALS OF THE RHEUMATIC DISEASES

The synovitis of "non-inflammatory" orthopaedic arthropathies: a quantitative histological and immunohistochemical analysis

(2008) F Pessler et al.   ANNALS OF THE RHEUMATIC DISEASES

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation

(2008) Andreas P. Sjöberg et al.   MOLECULAR IMMUNOLOGY

On new bone formation in the pre-osteoarthritic joint

(2008) A. Thambyah et al.   OSTEOARTHRITIS AND CARTILAGE

Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology

(2008) M. Geyer et al.   OSTEOARTHRITIS AND CARTILAGE