The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats

(2013) Songsong Zhu et al.   BONE

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis

(2013) Sinéad M. Ryan et al.   JOURNAL OF CONTROLLED RELEASE

Calcitonin delays the progress of early-stage mechanically induced osteoarthritis. In vivo, prospective study

(2013) M.J. Kyrkos et al.   OSTEOARTHRITIS AND CARTILAGE

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

(2012) De-gang Yu et al.   ACTA PHARMACOLOGICA SINICA

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

(2012) Jean-Yves Reginster et al.   ANNALS OF THE RHEUMATIC DISEASES

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

(2012) Jean-Pierre Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis

(2012) Willem E van Spil et al.   ANNALS OF THE RHEUMATIC DISEASES

Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: The In Vitro Osteoclast Differentiation in Arthritis study

(2012) Marianne Durand et al.   ARTHRITIS AND RHEUMATISM

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

PTHrP isoforms have differing effect on chondrogenic differentiation and hypertrophy of mesenchymal stem cells

(2012) Jong-Min Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Foreword: Osteoarthritis

(2012) Steven Goldring et al.   BONE

Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

(2012) Tadashi Hayami et al.   BONE

Prognostic biomarkers in osteoarthritis

(2012) Mukundan Attur et al.   CURRENT OPINION IN RHEUMATOLOGY

Phenotypic Characterization of Osteoarthritic Osteocytes from the Sclerotic Zones: A Possible Pathological Role in Subchondral Bone Sclerosis

(2012) Anjali Jaiprakash et al.   International Journal of Biological Sciences

Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients

(2012) D.D. Kumarasinghe et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees

(2012) C.-H. Chou et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone and osteoarthritis: biological and cellular aspects

(2012) Y. Henrotin et al.   OSTEOPOROSIS INTERNATIONAL

Targeting Bone Alleviates Osteoarthritis in Osteopenic Mice and Modulates Cartilage Catabolism

(2012) Thomas Funck-Brentano et al.   PLoS One

Improved Flow Cytometric Assessment Reveals Distinct Microvesicle (Cell-Derived Microparticle) Signatures in Joint Diseases

(2012) Bence György et al.   PLoS One

Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model

(2012) Pingping Chen-An et al.   RHEUMATOLOGY INTERNATIONAL

IL-6 Receptor Inhibition Positively Modulates Bone Balance in Rheumatoid Arthritis Patients with an Inadequate Response to Anti-Tumor Necrosis Factor Therapy: Biochemical Marker Analysis of Bone Metabolism in the Tocilizumab RADIATE Study (NCT00106522)

(2012) Morten A. Karsdal et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Inhibition of Cathepsin K for Treatment of Osteoporosis

(2012) Steven Boonen et al.   Current Osteoporosis Reports

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

(2012) Mary B. Goldring   Therapeutic Advances in Musculoskeletal Disease

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

(2012) Steven R. Goldring   Therapeutic Advances in Musculoskeletal Disease

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

(2011) Mukundan Attur et al.   ARTHRITIS AND RHEUMATISM

Fracture risk before and after total hip replacement in patients with osteoarthritis: Potential benefits of bisphosphonate use

(2011) Daniel Prieto-Alhambra et al.   ARTHRITIS AND RHEUMATISM

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Subchondral bone as a key target for osteoarthritis treatment

(2011) Santos Castañeda et al.   BIOCHEMICAL PHARMACOLOGY

Quantitative bone marrow lesion size in osteoarthritic knees correlates with cartilage damage and predicts longitudinal cartilage loss

(2011) Jeffrey B Driban et al.   BMC MUSCULOSKELETAL DISORDERS

Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

(2011) Steeve Kwan Tat et al.   BONE

Genetic factors in OA pathogenesis

(2011) Kay Chapman et al.   BONE

Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis

(2011) Liu Zhang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts

(2011) Addolorata Corrado et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

(2011) Thomas F. Chan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chondroprotective effect of alendronate in a rabbit model of osteoarthritis

(2011) Takaaki Shirai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover

(2011) R.H. Nielsen et al.   OSTEOARTHRITIS AND CARTILAGE

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis

(2011) M. Bellido et al.   OSTEOARTHRITIS AND CARTILAGE

Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus

(2011) B.C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis

(2011) J-Y. Reginster et al.   OSTEOPOROSIS INTERNATIONAL

Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

(2011) Kim Henriksen et al.   PLoS One

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

The Emerging Role of Dickkopf-1 in Bone Biology: Is It the Main Switch Controlling Bone and Joint Remodeling?

(2011) Dimitrios Daoussis et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Pharmacology of arthralgia with estrogen deprivation

(2011) Anneleen Lintermans et al.   STEROIDS

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

(2011) Mary B. Goldring et al.   TRENDS IN MOLECULAR MEDICINE

Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

(2011) Maxim Moreau et al.   ARTHRITIS RESEARCH & THERAPY

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

Mr Outside and Mr Inside: classic and alternative views on the pathogenesis of rheumatoid arthritis

(2010) G. Schett et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling

(2010) A. Kadri et al.   ANNALS OF THE RHEUMATIC DISEASES

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis - the effect of sex, Kellgren-Lawrence (KL) score, Body Mass Index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation

(2010) MA Karsdal et al.   BMC MUSCULOSKELETAL DISORDERS

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients

(2010) Sittisak Honsawek et al.   BMC MUSCULOSKELETAL DISORDERS

Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

(2010) Gideon A. Rodan   JOURNAL OF BONE AND MINERAL RESEARCH

Bone resorption by isolated human osteoclasts in vitro: Effects of calcitonin

(2010) Richard J. Murrills et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

(2010) John A Eisman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of denosumab on bone turnover markers in postmenopausal osteoporosis

(2010) Richard Eastell et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lessons Learned From the Development of Oral Calcitonin: The First Tablet Formulation of a Protein in Phase III Clinical Trials

(2010) M. A. Karsdal et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Treatment with Tiludronic Acid Helps Reduce the Development of Experimental Osteoarthritis Lesions in Dogs with Anterior Cruciate Ligament Transection Followed by Reconstructive Surgery: A 1-Year Study with Quantitative Magnetic Resonance Imaging

(2010) J.-P. PELLETIER et al.   JOURNAL OF RHEUMATOLOGY

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

(2010) J.J. McDougall et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease

(2010) B.W. Strassle et al.   OSTEOARTHRITIS AND CARTILAGE

Effect of Parathyroid Hormone on Type X and Type II Collagen Expression in Mesenchymal Stem Cells from Osteoarthritic Patients

(2010) Fackson Mwale et al.   TISSUE ENGINEERING PART A

Effects of Risedronate on Osteoarthritis of the Knee

(2010) Jun Iwamoto et al.   YONSEI MEDICAL JOURNAL

Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?

(2010) Steven R Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with rheumatoid arthritis and knee osteoarthritis

(2009) N Voorzanger-Rousselot et al.   ANNALS OF THE RHEUMATIC DISEASES

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations

(2009) M. Attur et al.   ANNALS OF THE RHEUMATIC DISEASES

Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression

(2009) Virginia Byers Kraus et al.   ARTHRITIS AND RHEUMATISM

Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits

(2009) Daisuke Takahashi et al.   ARTHRITIS AND RHEUMATISM

Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis

(2009) Heiner Appel et al.   ARTHRITIS AND RHEUMATISM

Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats

(2009) Je-Ken Chang et al.   ARTHRITIS AND RHEUMATISM

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

(2009) Denis Couchourel et al.   ARTHRITIS AND RHEUMATISM

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

(2009) Nathalie Amiable et al.   BONE

Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints

(2009) Kathryn S. Stok et al.   BONE

Influence of food intake on the bioavailability and efficacy of oral calcitonin

(2009) Morten A. Karsdal et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies

(2009) S A Stoch et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Accelerated Cartilage Resorption by Chondroclasts during Bone Fracture Healing in Osteoprotegerin-Deficient Mice

(2009) Norikazu Ota et al.   ENDOCRINOLOGY

Investigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacy

(2009) Morten A. Karsdal et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

(2009) J.R. Connor et al.   OSTEOARTHRITIS AND CARTILAGE

Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis

(2009) J.L. Huebner et al.   OSTEOARTHRITIS AND CARTILAGE

The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study

(2009) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

(2009) Anne-Christine Bay-Jensen et al.   RHEUMATOLOGY INTERNATIONAL

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

(2009) David J Hunter et al.   ARTHRITIS RESEARCH & THERAPY

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts

(2008) Steeve Kwan Tat et al.   ARTHRITIS AND RHEUMATISM

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor–transgenic mice

(2008) Uta Schurigt et al.   ARTHRITIS AND RHEUMATISM

PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs

(2008) Young-Ju Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Calcitonin ??? A Drug of the Past or for the Future?

(2008) Morten A Karsdal et al.   BIODRUGS

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation

(2008) MA Karsdal et al.   BMC MUSCULOSKELETAL DISORDERS

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors

(2008) Steeve Kwan Tat et al.   BONE

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Role of Bone in Osteoarthritis Pathogenesis

(2008) Steven R. Goldring   MEDICAL CLINICS OF NORTH AMERICA

Should subchondral bone turnover be targeted when treating osteoarthritis?

(2008) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis

(2008) M. Abdin-Mohamed et al.   OSTEOARTHRITIS AND CARTILAGE

Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI

(2008) E.B. Dam et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts

(2008) C. Sanchez et al.   OSTEOARTHRITIS AND CARTILAGE

Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

(2008) T. Vinardell et al.   OSTEOARTHRITIS AND CARTILAGE

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

(2008) G. J. Atkins et al.   OSTEOPOROSIS INTERNATIONAL

Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology

(2008) Mihra S. Taljanovic et al.   SKELETAL RADIOLOGY

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

(2008) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY

Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial

(2007) P. Garnero et al.   OSTEOARTHRITIS AND CARTILAGE