Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

Wnt signaling in cartilage development and degeneration

(2011) Jang-Soo Chun et al.   BMB Reports

Adamts5Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor β1 (TGFβ1) Signaling

(2011) Jennifer Velasco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-traumatic osteoarthritis: Improved understanding and opportunities for early intervention

(2011) Donald D. Anderson et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

(2011) A. Plaas et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis year 2010 in review: pathomechanisms

(2011) W.B. van den Berg   OSTEOARTHRITIS AND CARTILAGE

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

The anatomical basis for a novel classification of osteoarthritis and allied disorders

(2010) Dennis McGonagle et al.   JOURNAL OF ANATOMY

Type III Collagen, a Fibril Network Modifier in Articular Cartilage

(2010) Jiann-Jiu Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models

(2010) Jun Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage

(2010) T. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity

(2010) J.P. Moodie et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases

(2010) Takayuki Shiomi et al.   PATHOLOGY INTERNATIONAL

Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage

(2010) Rebecca Williams et al.   PLoS One

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Proteinases involved in matrix turnover during cartilage and bone breakdown

(2009) Tim E. Cawston et al.   CELL AND TISSUE RESEARCH

Development of a new method to harvest chondroprogenitor cells from underneath cartilage defects in the knees

(2009) Jan Elvenes et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage

(2008) Valeria M. Dejica et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene expression in human chondrocytes in late osteoarthritis is changed in both fibrillated and intact cartilage without evidence of generalised chondrocyte hypertrophy

(2008) C J Brew et al.   ANNALS OF THE RHEUMATIC DISEASES

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice

(2008) Qiuqian Wu et al.   ARTHRITIS AND RHEUMATISM

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of embryonic endochondral ossification by Smurf2

(2008) Qiuqian Wu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

L-Sox5 and Sox6 Drive Expression of the Aggrecan Gene in Cartilage by Securing Binding of Sox9 to a Far-Upstream Enhancer

(2008) Y. Han et al.   MOLECULAR AND CELLULAR BIOLOGY

Drug Insight: aggrecanases as therapeutic targets for osteoarthritis

(2008) Amanda J Fosang et al.   Nature clinical practice. Rheumatology

Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans

(2007) Shun-Fa Yang et al.   CLINICAL BIOCHEMISTRY