Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation

(2013) Gregor Sisask et al.   BONE

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin αIIbβ3Activation and Granule Secretion in Platelets

(2012) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

(2011) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway

(2011) R.L. Miclea et al.   OSTEOARTHRITIS AND CARTILAGE

AP-1 Is a Component of the Transcriptional Network Regulated by GSK-3 in Quiescent Cells

(2011) John W. Tullai et al.   PLoS One

PI3K-Dependent GSK3ß(Ser9)-Phosphorylation Is Implicated in the Intestinal Epithelial Cell Wound-Healing Response

(2011) Thomas Karrasch et al.   PLoS One

Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression

(2010) Jennifer H. Cox et al.   ARTHRITIS AND RHEUMATISM

GSK3β: role in therapeutic landscape and development of modulators

(2010) S Phukan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase 3: A point of convergence for the host inflammatory response

(2010) Huizhi Wang et al.   CYTOKINE

Protein Kinase C Isoforms ζ and ι Mediate Collagenase Expression and Cartilage Destruction via STAT3- and ERK-dependent c-fosInduction

(2010) Gary J. Litherland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP Suppresses Matrix Metalloproteinase-1 Expression through Inhibition of MAPK and GSK-3β

(2010) Chi-Hyun Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis

(2009) Mary-Clare Miller et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment

(2009) Meng-Huee Lee et al.   CANCER LETTERS

Glycogen synthase kinase-3  is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts

(2009) A. D. Kandasamy et al.   CARDIOVASCULAR RESEARCH

Smurf2 induces degradation of GSK-3β and upregulates β-catenin in chondrocytes: A potential mechanism for Smurf2-induced degeneration of articular cartilage

(2009) Qiuqian Wu et al.   EXPERIMENTAL CELL RESEARCH

Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes

(2009) Jason S. Rockel et al.   MATRIX BIOLOGY

Increased Expression of Metalloproteinase-8 and -13 on Articular Cartilage in a Rat Immobilized Knee Model

(2009) Akira Ando et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells

(2008) Signe Ingvarsen et al.   BIOLOGICAL CHEMISTRY

Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent

(2008) Gary J. Litherland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The regulation of matrix metalloproteinases and their inhibitors

(2007) I CLARK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY