Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids

pH Biosensing by PI4P Regulates Cargo Sorting at the TGN

(2020) John J.H. Shin et al.   DEVELOPMENTAL CELL

A new pH sensor localized in the Golgi apparatus of Saccharomyces cerevisiae reveals unexpected roles of Vph1p and Stv1p isoforms

(2020) Antoine Deschamps et al.   Scientific Reports

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases

(2020) Qiaoyun Song et al.   Translational Neurodegeneration

Distinct Mycobacterium marinum phosphatases determine pathogen vacuole phosphoinositide pattern, phagosome maturation and escape to the cytosol

(2019) Hendrik Koliwer-Brandl et al.   CELLULAR MICROBIOLOGY

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

(2019) Catherine M. Buckley et al.   PLoS Pathogens

Structural comparison of the vacuolar and Golgi V-ATPases from Saccharomyces cerevisiae

(2019) Thamiya Vasanthakumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function

(2019) Rebecca Wallings et al.   HUMAN MOLECULAR GENETICS

Interaction of the late endo-lysosomal lipid PI(3,5)P2 with the Vph1 isoform of yeast V-ATPase increases its activity and cellular stress tolerance

(2019) Subhrajit Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration

(2019) Takuo Hirose et al.   JOURNAL OF CLINICAL INVESTIGATION

Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells

(2019) Christina M. McGuire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BORC regulates late endosomal/lysosomal size through PIKfyve‐dependent phosphatidylinositol‐3,5‐bisphosphate

(2019) Teodor E. Yordanov et al.   TRAFFIC

Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis

(2019) Taki Nishimura et al.   MOLECULAR CELL

Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis

(2019) Craig Ramirez et al.   NATURE

The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

(2018) Bruno Antonny et al.   Annual Review of Biochemistry

Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2

(2018) Sonja A. Kirsch et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling

(2018) Christina M. McGuire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

(2018) Christopher H. Choy et al.   JOURNAL OF CELL SCIENCE

Modes of Interaction of Pleckstrin Homology Domains with Membranes: Toward a Computational Biochemistry of Membrane Recognition

(2018) Fiona B. Naughton et al.   JOURNAL OF MOLECULAR BIOLOGY

PI(3,5)P2 controls vacuole potassium transport to support cellular osmoregulation

(2018) Zachary N. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase V o Proton Channel

(2018) Soung-Hun Roh et al.   MOLECULAR CELL

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

(2018) Ji She et al.   NATURE

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

(2018) Zohreh Farsi et al.   eLife

Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation

(2018) Diego Sbrissa et al.   PLoS One

Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion

(2018) Gregory E. Miner et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

(2018) Marcus D. Goncalves et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphoinositide conversion in endocytosis and the endolysosomal system

(2017) Alexander Wallroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early protection to stress mediated by CDK-dependent PI3,5P2signaling from the vacuole/lysosome

(2017) Natsuko Jin et al.   JOURNAL OF CELL BIOLOGY

pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels

(2017) Amriya Naufer et al.   JOURNAL OF CELL BIOLOGY

Direct interaction of the Golgi V-ATPase a-subunit isoform with PI(4)P drives localization of Golgi V-ATPases in yeast

(2017) Subhrajit Banerjee et al.   MOLECULAR BIOLOGY OF THE CELL

Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis

(2017) Roni Levin et al.   MOLECULAR BIOLOGY OF THE CELL

A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage

(2017) K. Adam Bohnert et al.   NATURE

Breaking up and making up: The secret life of the vacuolar H+ -ATPase

(2017) Rebecca A. Oot et al.   PROTEIN SCIENCE

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

(2017) Maria B. Bagh et al.   Nature Communications

The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery

(2017) Anna Bodzęta et al.   Cell Reports

Molecular basis for the binding and modulation of V-ATPase by a bacterial effector protein

(2017) Jianhua Zhao et al.   PLoS Pathogens

The crucial impact of lysosomes in aging and longevity

(2016) Didac Carmona-Gutierrez et al.   AGEING RESEARCH REVIEWS

Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

(2016) Daniel J. Colacurcio et al.   AGEING RESEARCH REVIEWS

Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

(2016) Lauren M. Compton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction

(2016) John J.M. Bergeron et al.   Annual Review of Biochemistry

Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease

(2016) G. L. Dornan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic

(2016) Andrea L Marat et al.   EMBO JOURNAL

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

(2016) Kara G. Lassen et al.   IMMUNITY

Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes

(2016) Gina A. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Lipid Nanodisc-reconstituted Vacuolar ATPase Proton Channel

(2016) Nicholas J. Stam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic formation of ER–PM junctions presents a lipid phosphatase to regulate phosphoinositides

(2016) Eamonn J. Dickson et al.   JOURNAL OF CELL BIOLOGY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

A phosphoinositide conversion mechanism for exit from endosomes

(2016) Katharina Ketel et al.   NATURE

Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase

(2016) Mohammad T. Mazhab-Jafari et al.   NATURE

The Function of V-ATPases in Cancer

(2016) Laura Stransky et al.   PHYSIOLOGICAL REVIEWS

Single-vesicle imaging reveals different transport mechanisms between glutamatergic and GABAergic vesicles

(2016) Z. Farsi et al.   SCIENCE

The a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer

(2016) Kristina Cotter et al.   Oncotarget

Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion

(2015) Caroline Mauvezin et al.   Autophagy

Detection and manipulation of phosphoinositides

(2015) Olof Idevall-Hagren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Polyphosphoinositide binding domains: Key to inositol lipid biology

(2015) Gerald R.V. Hammond et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis

(2015) Ognian C. Ikonomov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration

(2015) Aline Dubos et al.   HUMAN MOLECULAR GENETICS

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole

(2015) Cheuk Y. Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

(2015) Laura A. Stransky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Affinity Purification and Structural Features of the Yeast Vacuolar ATPase VoMembrane Sector

(2015) Sergio Couoh-Cardel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron cryomicroscopy observation of rotational states in a eukaryotic V-ATPase

(2015) Jianhua Zhao et al.   NATURE

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

(2015) K. Rostislavleva et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells

(2014) Anna Boccaccio et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Saccharomyces cerevisiae Vacuolar H+-ATPase Regulation by Disassembly and Reassembly: One Structure and Multiple Signals

(2014) Karlett J. Parra et al.   EUKARYOTIC CELL

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

The signaling lipid PI(3,5)P2 stabilizes V1–Vo sector interactions and activates the V-ATPase

(2014) Sheena Claire Li et al.   MOLECULAR BIOLOGY OF THE CELL

PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

(2014) Grace H.E. Kim et al.   TRAFFIC

Endocytosis of Viruses and Bacteria

(2014) P. Cossart et al.   Cold Spring Harbor Perspectives in Biology

Phosphatidylinositol-4-phosphate: The Golgi and beyond

(2013) Maria A. De Matteis et al.   BIOESSAYS

Cinderella story: PI4P goes from precursor to key signaling molecule

(2013) Julie Tan et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)

(2013) Olena Korvatska et al.   HUMAN MOLECULAR GENETICS

Regulated Assembly of Vacuolar ATPase Is Increased during Cluster Disruption-induced Maturation of Dendritic Cells through a Phosphatidylinositol 3-Kinase/mTOR-dependent Pathway

(2013) Rachel Liberman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity

(2013) Yasuhiro Araki et al.   JOURNAL OF CELL BIOLOGY

The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery

(2013) Sandrine Poëa-Guyon et al.   JOURNAL OF CELL BIOLOGY

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Regulation of Luminal Acidification by the V-ATPase

(2013) Sylvie Breton et al.   PHYSIOLOGY

Measurement of Vacuolar and Cytosolic pH In Vivo in Yeast Cell Suspensions

(2013) Theodore T. Diakov et al.   Jove-Journal of Visualized Experiments

Sorting of the Yeast Vacuolar-type, Proton-translocating ATPase Enzyme Complex (V-ATPase)

(2012) Gregory C. Finnigan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase

(2012) Christopher S. Wood et al.   MOLECULAR BIOLOGY OF THE CELL

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

(2012) Sulochanadevi Baskaran et al.   MOLECULAR CELL

Phosphoinositide isoforms determine compartment-specific ion channel activity

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

(2012) G. R. V. Hammond et al.   SCIENCE

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Vacuolar H + -ATPase Works in Parallel with the HOG Pathway To Adapt Saccharomyces cerevisiae Cells to Osmotic Stress

(2011) Sheena Claire Li et al.   EUKARYOTIC CELL

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

The Endosomal Na+/H+Exchanger Contributes to Multivesicular Body Formation by Regulating the Recruitment of ESCRT-0 Vps27p to the Endosomal Membrane

(2011) Keiji Mitsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Consequences of Loss of Vph1 Protein-containing Vacuolar ATPases (V-ATPases) for Overall Cellular pH Homeostasis

(2011) Maureen Tarsio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Analysis Reveals the Vacuolar pH-Stat of Saccharomyces cerevisiae

(2011) Christopher L. Brett et al.   PLoS One

Anchors for Effectors: Subversion of Phosphoinositide Lipids by Legionella

(2011) Hubert Hilbi et al.   Frontiers in Microbiology

The role of PI3P phosphatases in the regulation of autophagy

(2010) Isabelle Vergne et al.   FEBS LETTERS

Regulation of Vacuolar Proton-translocating ATPase Activity and Assembly by Extracellular pH

(2010) Theodore T. Diakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Regulation of Golgi Phosphatidylinositol-4-Phosphate is Required for Enzyme Localization and Glycosylation Fidelity

(2010) Fei Ying Cheong et al.   TRAFFIC

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ionization Properties of Phosphatidylinositol Polyphosphates in Mixed Model Membranes

(2009) Edgar E. Kooijman et al.   BIOCHEMISTRY

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

Subunit Interactions and Requirements for Inhibition of the Yeast V1-ATPase

(2009) Heba Diab et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification

(2009) G.-H. Sun-Wada et al.   JOURNAL OF CELL SCIENCE

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The yeast lysosome-like vacuole: Endpoint and crossroads

(2008) Sheena Claire Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Multivesicular bodies

(2008) Michael J. Clague et al.   CURRENT BIOLOGY

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY

Vacuolar and Plasma Membrane Proton Pumps Collaborate to Achieve Cytosolic pH Homeostasis in Yeast

(2008) Gloria A. Martínez-Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus

(2008) Yusuke Maeda et al.   NATURE CELL BIOLOGY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY