Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis

(2016) Sandra Romero-Suarez et al.   Aging-US

Dissecting the localization and function of Atg18, Atg21 and Ygr223c

(2014) Roswitha Krick et al.   Autophagy

Dual Functions of Bruton's Tyrosine Kinase and Tec Kinase during Fc  Receptor-Induced Signaling and Phagocytosis

(2014) J. Jongstra-Bilen et al.   JOURNAL OF IMMUNOLOGY

The Role of Lipids in the Control of Autophagy

(2013) Claudia Dall'Armi et al.   CURRENT BIOLOGY

Small Molecule Inhibitors of Phospholipase C from a Novel High-throughput Screen

(2013) Weigang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

(2012) Diego Sbrissa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation and cellular functions of class II phosphoinositide 3-kinases

(2012) Marco Falasca et al.   BIOCHEMICAL JOURNAL

14-3-3 protein and ATRAP bind to the soluble class IIB phosphatidylinositol transfer protein RdgBβ at distinct sites

(2012) Shamshad Cockcroft et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Calcium signalling remodelling and disease

(2012) Michael J. Berridge   BIOCHEMICAL SOCIETY TRANSACTIONS

GPI-anchor remodeling: Potential functions of GPI-anchors in intracellular trafficking and membrane dynamics

(2012) Morihisa Fujita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis

(2012) W. Pan et al.   BLOOD

Revealing the role of phospholipase C 3 in the regulation of VEGF-induced vascular permeability

(2012) L. H. Hoeppner et al.   BLOOD

Characterization of AQX-1125, a small-molecule SHIP1 activator

(2012) Grant R Stenton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Characterization of AQX-1125, a small-molecule SHIP1 activator

(2012) Grant R Stenton et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing

(2012) Carl J. Mousley et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Yersinia Entry into Host Cells Requires Rab5-Dependent Dephosphorylation of PI(4,5)P2 and Membrane Scission

(2012) Helen Sarantis et al.   Cell Host & Microbe

Role of phospholipase Cε in physiological phosphoinositide signaling networks

(2012) Alan V. Smrcka et al.   CELLULAR SIGNALLING

PLCβ isoforms differ in their subcellular location and their CT-domain dependent interaction with Gαq

(2012) Merel J.W. Adjobo-Hermans et al.   CELLULAR SIGNALLING

Golgi Membrane Dynamics and Lipid Metabolism

(2012) Vytas A. Bankaitis et al.   CURRENT BIOLOGY

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

(2012) Angela Oppelt et al.   EMBO REPORTS

The Lowe syndrome protein OCRL1 is involved in primary cilia assembly

(2012) Brian G. Coon et al.   HUMAN MOLECULAR GENETICS

OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome

(2012) Na Luo et al.   HUMAN MOLECULAR GENETICS

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold

(2012) Miles J. Dixon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol Transfer Protein, Cytoplasmic 1 (PITPNC1) Binds and Transfers Phosphatidic Acid

(2012) Kathryn Garner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate Increases Ca2+Affinity of Synaptotagmin-1 by 40-fold

(2012) Geert van den Bogaart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4-Kinase IIα Is Palmitoylated by Golgi-localized Palmitoyltransferases in Cholesterol-dependent Manner

(2012) Dongmei Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

(2012) Florian Steinberg et al.   JOURNAL OF CELL BIOLOGY

Acute depletion of plasma membrane phosphatidylinositol 4,5-bisphosphate impairs specific steps in endocytosis of the G-protein-coupled receptor

(2012) D. J. Toth et al.   JOURNAL OF CELL SCIENCE

The NOXO1β PX Domain Preferentially Targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3

(2012) Nicole Y. Davis et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

(2012) Dave Bridges et al.   MOLECULAR BIOLOGY OF THE CELL

Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

(2012) Marko Jović et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological Diseases

(2012) Emma L. Clayton et al.   MOLECULAR NEUROBIOLOGY

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network

(2012) Lydia Daboussi et al.   NATURE CELL BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cold Urticaria, Immunodeficiency, and Autoimmunity Related toPLCG2Deletions

(2012) Michael J. Ombrello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of the Key Elements of FFAT-Like Motifs Identifies New Proteins That Potentially Bind VAP on the ER, Including Two AKAPs and FAPP2

(2012) Veronika Mikitova et al.   PLoS One

A Dual Polybasic Motif Determines Phosphoinositide Binding and Regulation in the P2X Channel Family

(2012) Louis-Philippe Bernier et al.   PLoS One

Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

(2012) B. Toth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

(2012) M. C. Humbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis

(2012) H. E. Cummings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-localized  -subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels

(2012) B.-C. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

(2012) G. R. V. Hammond et al.   SCIENCE

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

Direct Modification and Activation of a Nuclear Receptor-PIP2 Complex by the Inositol Lipid Kinase IPMK

(2012) R. D. Blind et al.   Science Signaling

Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL

(2012) Michelle Pirruccello et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of the tumor suppressor PTEN by SUMO

(2012) J González-Santamaría et al.   Cell Death & Disease

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

(2012) Annalisa Bianco et al.   PLoS Pathogens

STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane Junctions

(2011) Silvia Carrasco et al.   Annual Review of Biochemistry

Dynamin: Functional Design of a Membrane Fission Catalyst

(2011) Sandra L. Schmid et al.   Annual Review of Cell and Developmental Biology

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Phosphatidylinositol 4-phosphate 5-kinase Iγ_v6, a new splice variant found in rodents and humans

(2011) Yang Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evidence of SHIP2 Ser132phosphorylation, its nuclear localization and stability

(2011) William's Elong Edimo et al.   BIOCHEMICAL JOURNAL

Divergent effect of mammalian PLCζ in generating Ca2+oscillations in somatic cells compared with eggs

(2011) Sally V. Phillips et al.   BIOCHEMICAL JOURNAL

Novel regulation of PLCζ activity via its XY-linker

(2011) Michail Nomikos et al.   BIOCHEMICAL JOURNAL

The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein)

(2011) Kathryn Garner et al.   BIOCHEMICAL JOURNAL

Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

(2011) Rohan D. Teasdale et al.   BIOCHEMICAL JOURNAL

Molecular Mechanism of Cholesterol- and Polyphosphoinositide-Mediated Syntaxin Clustering

(2011) David H. Murray et al.   BIOCHEMISTRY

Recognition of polyunsaturated acyl chains by enzymes acting on membrane lipids

(2011) Richard M. Epand   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inositol lipid metabolism in mycobacteria: Biosynthesis and regulatory mechanisms

(2011) Yasu S. Morita et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

(2011) James R Brown et al.   BMC EVOLUTIONARY BIOLOGY

Doc2 Is a Ca2+ Sensor Required for Asynchronous Neurotransmitter Release

(2011) Jun Yao et al.   CELL

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Role of IP3 receptor in development

(2011) Katsuhiko Mikoshiba   CELL CALCIUM

Recruitment and Activation of a Lipid Kinase by Hepatitis C Virus NS5A Is Essential for Integrity of the Membranous Replication Compartment

(2011) Simon Reiss et al.   Cell Host & Microbe

Munc13 Homology Domain-1 in CAPS/UNC31 Mediates SNARE Binding Required for Priming Vesicle Exocytosis

(2011) Chuenchanok Khodthong et al.   Cell Metabolism

Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase

(2011) Seyun Kim et al.   Cell Metabolism

Metabolic Flux and the Regulation of Mammalian Cell Growth

(2011) Jason W. Locasale et al.   Cell Metabolism

Mitochondrial Phosphatase PTPMT1 Is Essential for Cardiolipin Biosynthesis

(2011) Ji Zhang et al.   Cell Metabolism

Multiple roles for Plasmodium berghei phosphoinositide-specific phospholipase C in regulating gametocyte activation and differentiation

(2011) Andreas C. Raabe et al.   CELLULAR MICROBIOLOGY

Mechanism of Activation and Inactivation of Gq/Phospholipase C-β Signaling Nodes

(2011) T. Kendall Harden et al.   CHEMICAL REVIEWS

Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action?

(2011) Shamshad Cockcroft et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans

(2011) L. J. Neukomm et al.   DEVELOPMENT

A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

(2011) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Genetic Defect in Phospholipase C 1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis

(2011) M. Hirata et al.   DIABETES

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

(2011) Xiaomin Hou et al.   EMBO JOURNAL

OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin

(2011) Mariella Vicinanza et al.   EMBO JOURNAL

Let's go bananas: revisiting the endocytic BAR code

(2011) Britta Qualmann et al.   EMBO JOURNAL

Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye

(2011) Taylor R. Murphy et al.   EXPERIMENTAL EYE RESEARCH

Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2

(2011) Eleonora Zakharian et al.   FASEB JOURNAL

Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish

(2011) Prakash C. Thakur et al.   HEPATOLOGY

Systematic Approaches towards the Development of Host-Directed Antiviral Therapeutics

(2011) Andrew Prussia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of a Proline-rich Inositol Polyphosphate 5-Phosphatase (PIPP)·Collapsin Response Mediator Protein 2 (CRMP2) Complex That Regulates Neurite Elongation

(2011) Megan V. Astle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlling the Activity of a Phosphatase and Tensin Homolog (PTEN) by Membrane Potential

(2011) Jérôme Lacroix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal Targeting of the Phosphoinositide 3-Phosphatase MTMR2 Is Regulated by an N-terminal Phosphorylation Site

(2011) Norah E. Franklin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of the PIP2 Sensor of TRPV1 Ion Channels

(2011) Carmen A. Ufret-Vincenty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122

(2011) Ryan R. Klein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

(2011) Ju He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis C Virus NS5A Protein Interacts with Phosphatidylinositol 4-Kinase Type IIIα and Regulates Viral Propagation

(2011) Yun-Sook Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Cytoplasmic Phosphatase and Tensin Homolog (PTEN)-like Region ofCiona intestinalisVoltage-sensing Phosphatase Provides Insight into Substrate Specificity and Redox Regulation of the Phosphoinositide Phosphatase Activity

(2011) Makoto Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

(2011) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cϵ Scaffolds to Muscle-specific A Kinase Anchoring Protein (mAKAPβ) and Integrates Multiple Hypertrophic Stimuli in Cardiac Myocytes

(2011) Lianghui Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

(2011) Mee-Sup Yoon et al.   JOURNAL OF CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Phospholipase C  binding to PtdIns(4,5)P2 requires the XY-linker region

(2011) M. Nomikos et al.   JOURNAL OF CELL SCIENCE

Voltage sensitive phosphoinositide phosphatases of Xenopus: Their tissue distribution and voltage dependence

(2011) William J. Ratzan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2hydrolysis

(2011) Julia F. Doerner et al.   JOURNAL OF GENERAL PHYSIOLOGY

Class IA Phosphoinositide 3-Kinase   and   Regulate Neutrophil Oxidase Activation in Response to Aspergillus fumigatus Hyphae

(2011) K. B. Boyle et al.   JOURNAL OF IMMUNOLOGY

A-Kinase Anchoring Protein 150 Mediates Transient Receptor Potential Family V Type 1 Sensitivity to Phosphatidylinositol-4,5-Bisphosphate

(2011) N. A. Jeske et al.   JOURNAL OF NEUROSCIENCE

Congenital CNS Hypomyelination in the Fig4 Null Mouse Is Rescued by Neuronal Expression of the PI(3,5)P2 Phosphatase Fig4

(2011) J. J. Winters et al.   JOURNAL OF NEUROSCIENCE

Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations

(2011) Jill L. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Probing the regulation of TASK potassium channels by PI(4,5)P2with switchable phosphoinositide phosphatases

(2011) Moritz Lindner et al.   JOURNAL OF PHYSIOLOGY-LONDON

FERM Domain Phosphoinositide Binding Targets Merlin to the Membrane and Is Essential for Its Growth-Suppressive Function

(2011) T. Mani et al.   MOLECULAR AND CELLULAR BIOLOGY

Membrane Environment Exerts an Important Influence on Rac-Mediated Activation of Phospholipase C 2

(2011) K. L. Everett et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor

(2011) Qing Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

(2011) Costin N. Antonescu et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages

(2011) Urszula Golebiewska et al.   MOLECULAR BIOLOGY OF THE CELL

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

(2011) Xunhao Xiong et al.   MOLECULAR BIOLOGY OF THE CELL

PLCζ causes Ca2+ oscillations in mouse eggs by targeting intracellular and not plasma membrane PI(4,5)P2

(2011) Yuansong Yu et al.   MOLECULAR BIOLOGY OF THE CELL

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

(2011) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

(2011) Xuxiao Zhang et al.   MOLECULAR CELL

Membrane protein sequestering by ionic protein–lipid interactions

(2011) Geert van den Bogaart et al.   NATURE

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis

(2011) Daphné Dambournet et al.   NATURE CELL BIOLOGY

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese

(2011) Zhibin Hu et al.   NATURE GENETICS

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recognition of the F&H motif by the Lowe syndrome protein OCRL

(2011) Michelle Pirruccello et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

(2011) Angeline M Lyon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phospholipid-dependent regulation of the motor activity of myosin X

(2011) Nobuhisa Umeki et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Voltage-Sensing Phosphatase: Its Molecular Relationship With PTEN

(2011) Yasushi Okamura et al.   PHYSIOLOGY

Protein Kinase D Signaling: Multiple Biological Functions in Health and Disease

(2011) Enrique Rozengurt   PHYSIOLOGY

A Mutation in Synaptojanin 2 Causes Progressive Hearing Loss in the ENU-Mutagenised Mouse Strain Mozart

(2011) Shehnaaz S. M. Manji et al.   PLoS One

The Ras–PI3K Signaling Pathway Is Involved in Clathrin-Independent Endocytosis and the Internalization of Influenza Viruses

(2011) Yoichiro Fujioka et al.   PLoS One

A Genetically Encoded Tool Kit for Manipulating and Monitoring Membrane Phosphatidylinositol 4,5-Bisphosphate in Intact Cells

(2011) Fabian Hertel et al.   PLoS One

The Distribution of Phosphatidylinositol 4,5-Bisphosphate in Acinar Cells of Rat Pancreas Revealed with the Freeze-Fracture Replica Labeling Method

(2011) Nami Ozato-Sakurai et al.   PLoS One

Lowe Syndrome Protein OCRL1 Supports Maturation of Polarized Epithelial Cells

(2011) Adam G. Grieve et al.   PLoS One

Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome

(2011) Stine A. Danielsen et al.   PLoS One

The Role of the Phosphatidylinositol 4-Kinase PI4KA in Hepatitis C Virus-Induced Host Membrane Rearrangement

(2011) Andrew W. Tai et al.   PLoS One

SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses

(2011) S. J. Koo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB

(2011) D. Maag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view

(2011) Helio Miranda Costa-Junior et al.   Purinergic Signalling

Hepatitis c virus and host cell lipids: An intimate connection

(2011) Gualtiero Alvisi et al.   RNA Biology

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Function of Rhodopsin in Temperature Discrimination in Drosophila

(2011) W. L. Shen et al.   SCIENCE

Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization

(2011) T. Ueno et al.   Science Signaling

Shigella flexneri Infection Generates the Lipid PI5P to Alter Endocytosis and Prevent Termination of EGFR Signaling

(2011) D. Ramel et al.   Science Signaling

Moving in the right direction: How eukaryotic cells migrate along chemical gradients

(2011) Huaqing Cai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SNX-BAR-Mediated Endosome Tubulation is Co-ordinated with Endosome Maturation

(2011) Jan R.T. van Weering et al.   TRAFFIC

Phosphoinositides in Cell Architecture

(2011) A. Shewan et al.   Cold Spring Harbor Perspectives in Biology

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells

(2011) Peter J. Wen et al.   Nature Communications

High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability

(2011) Lydia W.T. Cheung et al.   Cancer Discovery

Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity

(2011) Jia Xie et al.   Scientific Reports

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J

(2011) Guy M. Lenk et al.   PLoS Genetics

Anchors for Effectors: Subversion of Phosphoinositide Lipids by Legionella

(2011) Hubert Hilbi et al.   Frontiers in Microbiology

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment

(2010) Erica L. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Eukaryotic Chemotaxis: A Network of Signaling Pathways Controls Motility, Directional Sensing, and Polarity

(2010) Kristen F. Swaney et al.   Annual Review of Biophysics

Regulation of PIKfyve phosphorylation by insulin and osmotic stress

(2010) Elaine V. Hill et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genomic tagging reveals a random association of endogenous PtdIns5P4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform

(2010) Minchuan Wang et al.   BIOCHEMICAL JOURNAL

PIP4Kβ interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kα

(2010) Yvette Bultsma et al.   BIOCHEMICAL JOURNAL

ADF/Cofilin Binds Phosphoinositides in a Multivalent Manner to Act as a PIP2-Density Sensor

(2010) Hongxia Zhao et al.   BIOPHYSICAL JOURNAL

PI3K/p110  is a novel therapeutic target in multiple myeloma

(2010) H. Ikeda et al.   BLOOD

Lyn- and PLC- 3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease

(2010) W. Xiao et al.   BLOOD

Deletion of the p110  isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo

(2010) V. Martin et al.   BLOOD

PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

(2010) A. Vaid et al.   BLOOD

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

Mtmr8 is essential for vasculature development in zebrafish embryos

(2010) Jie Mei et al.   BMC DEVELOPMENTAL BIOLOGY

A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression

(2010) David Kerk et al.   BMC EVOLUTIONARY BIOLOGY

A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis

(2010) Nicola J Beresford et al.   BMC GENOMICS

The Phosphoinositide 3-Kinase Regulatory Subunit p85  Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling

(2010) C. M. Taniguchi et al.   CANCER RESEARCH

Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids

(2010) Katarina Moravcevic et al.   CELL

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Signaling From the Golgi: Mechanisms and Models for Golgi Phosphoprotein 3-Mediated Oncogenesis

(2010) K. L. Scott et al.   CLINICAL CANCER RESEARCH

Mammalian diseases of phosphatidylinositol transfer proteins and their homologs

(2010) Aaron H Nile et al.   Clinical Lipidology

Activation of TRP Channels by Protons and Phosphoinositide Depletion in Drosophila Photoreceptors

(2010) Jiehong Huang et al.   CURRENT BIOLOGY

Synergistic Activation of Phospholipase C-β3 by Gαq and Gβγ Describes a Simple Two-State Coincidence Detector

(2010) Finly Philip et al.   CURRENT BIOLOGY

Manipulation of host membrane machinery by bacterial pathogens

(2010) Pascale Cossart et al.   CURRENT OPINION IN CELL BIOLOGY

Inositol phosphate synthesis and the nuclear processes they affect

(2010) Jessica P Monserrate et al.   CURRENT OPINION IN CELL BIOLOGY

Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis

(2010) Mark T Howes et al.   CURRENT OPINION IN CELL BIOLOGY

Cell biology of Ca2+-triggered exocytosis

(2010) Zhiping P Pang et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p

(2010) Emi Mizuno-Yamasaki et al.   DEVELOPMENTAL CELL

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

(2010) Andrew Manford et al.   EMBO JOURNAL

Structural basis of wedging the Golgi membrane by FAPP pleckstrin homology domains

(2010) Marc Lenoir et al.   EMBO REPORTS

Phosphatidylinositol 3-Phosphate, an Essential Lipid in Plasmodium, Localizes to the Food Vacuole Membrane and the Apicoplast

(2010) Lina Tawk et al.   EUKARYOTIC CELL

Biophysical characterization of the fluorescent protein voltage probe VSFP2.3 based on the voltage-sensing domain of Ci-VSP

(2010) Alicia Lundby et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Interaction between Sec7p and Pik1p: The first clue for the regulation of a coincidence detection signal

(2010) Yvonne Gloor et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathway

(2010) Eric S. White et al.   EXPERIMENTAL CELL RESEARCH

Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion

(2010) Barbara Leibiger et al.   FASEB JOURNAL

The role of PI3P phosphatases in the regulation of autophagy

(2010) Isabelle Vergne et al.   FEBS LETTERS

Mucolipins: Intracellular TRPML1-3 channels

(2010) Xiping Cheng et al.   FEBS LETTERS

Phospholipase C-eta2 is highly expressed in the habenula and retina

(2010) Kaori Kanemaru et al.   GENE EXPRESSION PATTERNS

Zebrafish MTMR14 is required for excitation–contraction coupling, developmental motor function and the regulation of autophagy

(2010) J.J. Dowling et al.   HUMAN MOLECULAR GENETICS

Multiple Host Proteins That Function in Phosphatidylinositol-4-Phosphate Metabolism Are Recruited to the Chlamydial Inclusion

(2010) A. M. Moorhead et al.   INFECTION AND IMMUNITY

Genetics of childhood-onset inflammatory bowel disease

(2010) Paul Henderson et al.   INFLAMMATORY BOWEL DISEASES

A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease

(2010) John A. Marwick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes

(2010) Junjing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

(2010) Helene Maccario et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Key Role for the Phosphorylation of Ser440by the Cyclic AMP-dependent Protein Kinase in Regulating the Activity of the Src Homology 2 Domain-containing Inositol 5′-Phosphatase (SHIP1)

(2010) Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells

(2010) Veronica Dominguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2

(2010) Helena A. Walz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ArPIKfyve Regulates Sac3 Protein Abundance and Turnover

(2010) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility via Activation of the Ryanodine Receptor

(2010) Chad D. Touchberry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-induced Synthesis of Phosphatidylinositol 3-Phosphate in Mycobacteria

(2010) Yasu S. Morita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain

(2010) Laura A. Volpicelli-Daley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Phosphorylation-induced Activation of Phospholipase C-γ Isozymes

(2010) Aurelie Gresset et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of mRNA Export and Translation Termination by Inositol Hexakisphosphate Requires Specific Interaction with Gle1

(2010) Abel R. Alcázar-Román et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cδ3 Regulates RhoA/Rho Kinase Signaling and Neurite Outgrowth

(2010) Zen Kouchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin and IP3-induced Ca2+Release from Intracellular Stores in the Malaria ParasitePlasmodium falciparumwithin Infected Red Blood Cells

(2010) Eduardo Alves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

(2010) Michal Bohdanowicz et al.   JOURNAL OF CELL BIOLOGY

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics

(2010) Fubito Nakatsu et al.   JOURNAL OF CELL BIOLOGY

Ras-mediated activation of the TORC2–PKB pathway is critical for chemotaxis

(2010) Huaqing Cai et al.   JOURNAL OF CELL BIOLOGY

The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy

(2010) Zhixun Dou et al.   JOURNAL OF CELL BIOLOGY

DrosophilaMtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions

(2010) Michaella Velichkova et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITP  is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum

(2010) N. Carvou et al.   JOURNAL OF CELL SCIENCE

Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics

(2010) J. R. Halstead et al.   JOURNAL OF CELL SCIENCE

The myotubularin phosphatase MTMR4 regulates sorting from early endosomes

(2010) M. J. Naughtin et al.   JOURNAL OF CELL SCIENCE

PtdIns(3,4,5)P3 is a regulator of myosin-X localization and filopodia formation

(2010) L. Plantard et al.   JOURNAL OF CELL SCIENCE

Activation and regulation of store-operated calcium entry

(2010) Jeremy T. Smyth et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle

(2010) Karim Hnia et al.   JOURNAL OF CLINICAL INVESTIGATION

Kinetics of M1muscarinic receptor and G protein signaling to phospholipase C in living cells

(2010) Björn H. Falkenburger et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kinetics of PIP2metabolism and KCNQ2/3 channel regulation studied with a voltage-sensitive phosphatase in living cells

(2010) Björn H. Falkenburger et al.   JOURNAL OF GENERAL PHYSIOLOGY

SHIP Is Required for Dendritic Cell Maturation

(2010) F. Antignano et al.   JOURNAL OF IMMUNOLOGY

Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIα at thetrans-Golgi network

(2010) Shane Minogue et al.   JOURNAL OF LIPID RESEARCH

Phosphatidylinositol-4,5-bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization

(2010) Aurélie Bertin et al.   JOURNAL OF MOLECULAR BIOLOGY

Ca2+-Dependent Desensitization of TRPV2 Channels Is Mediated by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate

(2010) J. Mercado et al.   JOURNAL OF NEUROSCIENCE

Ins(1,4,5)P3interacts with PIP2to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes

(2010) Min Ju et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mouse Model for Lowe Syndrome/Dent Disease 2 Renal Tubulopathy

(2010) S. P. Bothwell et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complementation of Saccharomyces cerevisiae pik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum

(2010) Tim Krüger et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C

(2010) Simge Akbulut et al.   MOLECULAR BIOLOGY OF THE CELL

Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility

(2010) Elisa Ciraolo et al.   MOLECULAR BIOLOGY OF THE CELL

Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα

(2010) Sangeeta Banerji et al.   MOLECULAR BIOLOGY OF THE CELL

Requirement for Golgi-localized PI(4)P in fusion of COPII vesicles with Golgi compartments

(2010) Andrés Lorente-Rodríguez et al.   MOLECULAR BIOLOGY OF THE CELL

The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain

(2010) Yoshiyuki Soeda et al.   MOLECULAR ENDOCRINOLOGY

Multivariate analysis of male reproductive function in Inpp5b−/− mice reveals heterogeneity in defects in fertility, sperm–egg membrane interaction and proteolytic cleavage of sperm ADAMs

(2010) Matthew R. Marcello et al.   MOLECULAR HUMAN REPRODUCTION

Requirement of a specific group of sphingolipid-metabolizing enzyme for growth of yeast Saccharomyces cerevisiae under impaired metabolism of glycerophospholipids

(2010) Motohiro Tani et al.   MOLECULAR MICROBIOLOGY

A systematic screen for protein–lipid interactions in Saccharomyces cerevisiae

(2010) Oriol Gallego et al.   Molecular Systems Biology

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

(2010) Junko Sasaki et al.   NATURE

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP

(2010) Susy C Kohout et al.   Nature Chemical Biology

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

(2010) Alex Berndt et al.   Nature Chemical Biology

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

(2010) Christian C Abnet et al.   NATURE GENETICS

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-vesicular lipid transport by lipid-transfer proteins and beyond

(2010) Sima Lev   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis

(2010) Ok-Ho Shin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Modulation of High-Voltage Activated Ca2+ Channels by Membrane Phosphatidylinositol 4,5-Bisphosphate

(2010) Byung-Chang Suh et al.   NEURON

Channelopathies linked to plasma membrane phosphoinositides

(2010) Diomedes E. Logothetis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of the Actin Cytoskeleton-Plasma Membrane Interplay by Phosphoinositides

(2010) Juha Saarikangas et al.   PHYSIOLOGICAL REVIEWS

Phospholipase C Gamma 2 Is Critical for Development of a Murine Model of Inflammatory Arthritis by Affecting Actin Dynamics in Dendritic Cells

(2010) Viviana Cremasco et al.   PLoS One

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

(2010) Marie-Josée Langlois et al.   PLoS One

The Biphasic Increase of PIP2 in the Fertilized Eggs of Starfish: New Roles in Actin Polymerization and Ca2+ Signaling

(2010) Jong T. Chun et al.   PLoS One

Phosphoinositide-binding interface proteins involved in shaping cell membranes

(2010) Tadaomi TAKENAWA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Proteomic identification of phosphatidylinositol (3,4,5) triphosphate-binding proteins in Dictyostelium discoideum

(2010) P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A biochemical mechanism for the oncogenic potential of the p110  catalytic subunit of phosphoinositide 3-kinase

(2010) H. A. Dbouk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

(2010) C. G. Fedele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MTM1 mutation associated with X-linked myotubular myopathy in Labrador Retrievers

(2010) A. H. Beggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling

(2010) Z. Szentpetery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA

(2010) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear phosphoinositide 3-kinase   controls double-strand break DNA repair

(2010) A. Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

(2010) R. B. Chagpar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A constitutively activated form of the p110  isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice

(2010) S. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

Kinetic Scaffolding Mediated by a Phospholipase C-  and Gq Signaling Complex

(2010) G. L. Waldo et al.   SCIENCE

A Vibrio Effector Protein Is an Inositol Phosphatase and Disrupts Host Cell Membrane Integrity

(2010) C. A. Broberg et al.   SCIENCE

Zebrafish Class 1 Phosphatidylinositol Transfer Proteins: PITPβ and Double Cone Cell Outer Segment Integrity in Retina

(2010) Kristina E. Ile et al.   TRAFFIC

Coordination of Golgi functions by phosphatidylinositol 4-kinases

(2010) Todd R. Graham et al.   TRENDS IN CELL BIOLOGY

EHD proteins: key conductors of endocytic transport

(2010) Naava Naslavsky et al.   TRENDS IN CELL BIOLOGY

IP3 Receptors: Toward Understanding Their Activation

(2010) C. W. Taylor et al.   Cold Spring Harbor Perspectives in Biology

ITAM-mediated Signaling by the T-Cell Antigen Receptor

(2010) P. E. Love et al.   Cold Spring Harbor Perspectives in Biology

T-Cell Signaling Regulated by the Tec Family Kinase, Itk

(2010) A. H. Andreotti et al.   Cold Spring Harbor Perspectives in Biology

Identification and Characterization of Novel Inhibitors of mPTPB, an Essential Virulent Phosphatase from Mycobacterium tuberculosis

(2010) Lan Chen et al.   ACS Medicinal Chemistry Letters

PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1α in Jurkat T cells

(2009) Yuichiro Matsushita et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

The p85β regulatory subunit of phosphoinositide 3-kinase has unique and redundant functions in B cells

(2009) Jean S. Oak et al.   AUTOIMMUNITY

YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes

(2009) Ognian C. Ikonomov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two novel phosphatidylinositol-4-phosphate 5-kinase type Iγ splice variants expressed in human cells display distinctive cellular targeting

(2009) Nicholas J. Schill et al.   BIOCHEMICAL JOURNAL

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

(2009) Pamela J. Plant et al.   BIOCHEMICAL JOURNAL

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

(2009) Stephen K. Dove et al.   BIOCHEMICAL JOURNAL

Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry

(2009) Ciara M. Walsh et al.   BIOCHEMICAL JOURNAL

Investigation of the H+–myo-inositol transporter (HMIT) as a neuronal regulator of phosphoinositide signalling: Figure 1

(2009) Elena Di Daniel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

(2009) Y. Li et al.   BLOOD

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

Bipolar disorder and mechanisms of action of mood stabilizers

(2009) Stanley I. Rapoport et al.   BRAIN RESEARCH REVIEWS

Tumor Suppression by Phospholipase C-β3 via SHP-1-Mediated Dephosphorylation of Stat5

(2009) Wenbin Xiao et al.   CANCER CELL

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

(2009) Bijay S. Jaiswal et al.   CANCER CELL

Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase

(2009) H. Pang et al.   CANCER RESEARCH

Phospholipase Cε promotes intestinal tumorigenesis of Apc Min/+ mice through augmentation of inflammation and angiogenesis

(2009) Mingzhen Li et al.   CARCINOGENESIS

GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote Budding

(2009) Holly C. Dippold et al.   CELL

Functional Reconstitution of ESCRT-III Assembly and Disassembly

(2009) Suraj Saksena et al.   CELL

The BAR Domain Superfamily: Membrane-Molding Macromolecules

(2009) Adam Frost et al.   CELL

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

(2009) Andrew W. Tai et al.   Cell Host & Microbe

Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain

(2009) Jing Gao et al.   CELLULAR SIGNALLING

Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness

(2009) Wenting Zhu et al.   CIRCULATION RESEARCH

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Small Molecule Inhibitors of Phosphoinositide 3-Kinase (PI3K) δ and γ

(2009) Michael Ameriks et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits

(2009) Shawn Ferguson et al.   DEVELOPMENTAL CELL

Insulin Granule Recruitment and Exocytosis Is Dependent on p110  in Insulinoma and Human  -Cells

(2009) G. M. Pigeau et al.   DIABETES

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

(2009) Isabelle Vergne et al.   EMBO JOURNAL

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

(2009) Yuxin Mao et al.   EMBO JOURNAL

A protein complex that regulates PtdIns(3,5)P2 levels

(2009) Robert H Michell et al.   EMBO JOURNAL

Structural insights into the dual nucleotide exchange and GDI displacement activity of SidM/DrrA

(2009) Hye-Young Suh et al.   EMBO JOURNAL

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1

(2009) Ivan Ivetac et al.   EMBO REPORTS

Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening

(2009) Maud Trotard et al.   FASEB JOURNAL

Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1

(2009) Yiming Chang et al.   FEBS LETTERS

Protein kinase C isoforms: Multi-functional regulators of cell life and death

(2009) Mary et al.   Frontiers in Bioscience-Landmark

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Tetraspanin CD81 Is Required for Listeria monocytogenes Invasion

(2009) T. N. Tham et al.   INFECTION AND IMMUNITY

A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum

(2009) Werner Leber et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides

(2009) Marek K. Korzeniowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phox Domain of Sorting Nexin 5 Lacks Phosphatidylinositol 3-Phosphate (PtdIns(3)P) Specificity and Preferentially Binds to Phosphatidylinositol 4,5-Bisphosphate (PtdIns(4,5)P2)

(2009) Leonardus M. I. Koharudin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Clathrin Binding and Subcellular Localization of OCRL1 Splice Isoforms

(2009) Rawshan Choudhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clathrin Regulates the Association of PIPKIγ661 with the AP-2 Adaptor β2 Appendage

(2009) James R. Thieman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification ofmyo-Inositol-3-phosphate Synthase Isoforms

(2009) Ratnam S. Seelan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Decreases Phosphatidylinositol 4,5-Bisphosphate Levels by Deactivating Phosphatidylinositol- 4-phosphate 5-Kinase β in a Syk-dependent Manner

(2009) Mark Z. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Turtles All the Way: Reflections on myo-Inositol: FIGURE 1.

(2009) Bernard W. Agranoff   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation Controls the Catalytic Activity and Subcellular Distribution of Phosphatidylinositol 4-Kinase IIα

(2009) Barbara Barylko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localized Diacylglycerol-dependent Stimulation of Ras and Rap1 during Phagocytosis

(2009) Roberto J. Botelho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Sphingolipid Metabolism by the Phosphatidylinositol-4-phosphate Phosphatase Sac1p through Regulation of Phosphatidylinositol inSaccharomyces cerevisiae

(2009) Sarah E. Brice et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase

(2009) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

(2009) Katy L. Everett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Phospholipase C-β2Activity and Membrane Interaction by Gαq, Gβ1γ2, and Rac2

(2009) Orit Gutman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM and Orai: Dynamic Intermembrane Coupling to Control Cellular Calcium Signals

(2009) Xiaoxiang Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis

(2009) Yuntao S. Mao et al.   JOURNAL OF CELL BIOLOGY

Reversible binding and rapid diffusion of proteins in complex with inositol lipids serves to coordinate free movement with spatial information

(2009) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

Dual roles for theDrosophilaPI 4-kinase Four wheel drive in localizing Rab11 during cytokinesis

(2009) Gordon Polevoy et al.   JOURNAL OF CELL BIOLOGY

PtdIns4Precognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking

(2009) Christopher S. Wood et al.   JOURNAL OF CELL BIOLOGY

The  - and  -isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells

(2009) L. Vasudevan et al.   JOURNAL OF CELL SCIENCE

No strings attached: the ESCRT machinery in viral budding and cytokinesis

(2009) B. McDonald et al.   JOURNAL OF CELL SCIENCE

Crucial role of phosphatidylinositol 4-kinase III  in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling

(2009) H. Ma et al.   JOURNAL OF CELL SCIENCE

Apical trafficking in epithelial cells: signals, clusters and motors

(2009) O. A. Weisz et al.   JOURNAL OF CELL SCIENCE

Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins

(2009) Z. Wang et al.   JOURNAL OF CELL SCIENCE

Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIγ in the mouse brain

(2009) Jonathan H. Clarke et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Critical role of phospholipase Cγ2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis

(2009) Zoltán Jakus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coupling between the voltage-sensing and phosphatase domains of Ci-VSP

(2009) Carlos A. Villalba-Galea et al.   JOURNAL OF GENERAL PHYSIOLOGY

Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation

(2009) B. Sarraj et al.   JOURNAL OF IMMUNOLOGY

The TC10-Exo70 Complex Is Essential for Membrane Expansion and Axonal Specification in Developing Neurons

(2009) S. Dupraz et al.   JOURNAL OF NEUROSCIENCE

Dlg1, Sec8, and Mtmr2 Regulate Membrane Homeostasis in Schwann Cell Myelination

(2009) A. Bolis et al.   JOURNAL OF NEUROSCIENCE

Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication

(2009) J. Borawski et al.   JOURNAL OF VIROLOGY

Roles of BLOC-1 and Adaptor Protein-3 Complexes in Cargo Sorting to Synaptic Vesicles

(2009) Karen Newell-Litwa et al.   MOLECULAR BIOLOGY OF THE CELL

A Cdc42 Activation Cycle Coordinated by PI 3-Kinase during Fc Receptor-mediated Phagocytosis

(2009) Peter Beemiller et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Insights into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2

(2009) Tom D. Bunney et al.   MOLECULAR CELL

Subtype-Specific Regulation of P2X3 and P2X2/3 Receptors by Phosphoinositides in Peripheral Nociceptors

(2009) Gary Mo et al.   Molecular Pain

The Small GTPase Ral Couples the Angiotensin II Type 1 Receptor to the Activation of Phospholipase C- 1

(2009) C. M. Godin et al.   MOLECULAR PHARMACOLOGY

Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

(2009) M. Aittaleb et al.   MOLECULAR PHARMACOLOGY

Phosphatidylinositol (4,5)-Bisphosphate Regulation of N-Methyl-D-aspartate Receptor Channels in Cortical Neurons

(2009) M. Mandal et al.   MOLECULAR PHARMACOLOGY

Membrane scission by the ESCRT-III complex

(2009) Thomas Wollert et al.   NATURE

Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis

(2009) Jinhua Shen et al.   NATURE CELL BIOLOGY

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

(2009) Stephanie L Bielas et al.   NATURE GENETICS

PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane

(2009) Kristin L Arendt et al.   NATURE NEUROSCIENCE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer

(2009) X -T Hu et al.   ONCOGENE

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

(2009) L Davidson et al.   ONCOGENE

Cooperation of Mtmr8 with PI3K Regulates Actin Filament Modeling and Muscle Development in Zebrafish

(2009) Jie Mei et al.   PLoS One

Nuclear Envelope Remnants: Fluid Membranes Enriched in STEROLS and Polyphosphoinositides

(2009) Marie Garnier-Lhomme et al.   PLoS One

Patterned Neuroprotection in the Inpp4awbl Mutant Mouse Cerebellum Correlates with the Expression of Eaat4

(2009) Andrew J. Sachs et al.   PLoS One

Knockin of mutant PIK3CA activates multiple oncogenic pathways

(2009) John P. Gustin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates the electrogenic Na/HCO3 cotransporter NBCe1-A expressed in Xenopus oocytes

(2009) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110  and are disrupted in oncogenic p85 mutants

(2009) H. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CAPS drives trans-SNARE complex formation and membrane fusion through syntaxin interactions

(2009) D. J. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110 

(2009) B. Kurig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol phosphatase SHIP1 is a primary target of miR-155

(2009) R. M. O'Connell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication

(2009) M. Marques et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons

(2009) J. Paul Simons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

(2009) K. L. Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane

(2009) D. Mandelker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian phosphoinositide kinases and phosphatases

(2009) Takehiko Sasaki et al.   PROGRESS IN LIPID RESEARCH

PI3K  Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells

(2009) T. Bohnacker et al.   Science Signaling

SNX–BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting

(2009) Jan R.T. van Weering et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling

(2009) Vytas A. Bankaitis et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

(2009) Frédéric H. Vaillancourt et al.   VIROLOGY

Targeting host factors: A novel rationale for the management of hepatitis C virus

(2009) Mahmoud Aboelneen Khattab   WORLD JOURNAL OF GASTROENTEROLOGY

Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome

(2008) Jacob A.S. Vorstman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate

(2008) Donghee Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Genetic Variation in Inositol Polyphosphate 4 Phosphatase A Enhances Susceptibility to Asthma

(2008) Mamta Sharma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

Ypp1/YGR198w plays an essential role in phosphoinositide signalling at the plasma membrane

(2008) Chao Zhai et al.   BIOCHEMICAL JOURNAL

Molecular determinants of activation and membrane targeting of phosphoinositol 4-kinase IIβ

(2008) Gwanghyun Jung et al.   BIOCHEMICAL JOURNAL

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

PTEN Phosphatase Selectively Binds Phosphoinositides and Undergoes Structural Changes†

(2008) Roberta E. Redfern et al.   BIOCHEMISTRY

Activation of Human Phospholipase C-η2 by Gβγ†

(2008) Yixing Zhou et al.   BIOCHEMISTRY

The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins†

(2008) Margot G. Paulick et al.   BIOCHEMISTRY

Involvement of Phosphatidylinositol 4,5-Bisphosphate in the Desensitization of Canonical Transient Receptor Potential 5

(2008) Byung Joo Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Crucial Role of Phospholipase C  in Skin Inflammation Induced by Tumor-Promoting Phorbol Ester

(2008) S. Ikuta et al.   CANCER RESEARCH

Phospholipase C 1 Is Required for Metastasis Development and Progression

(2008) G. Sala et al.   CANCER RESEARCH

Portrait of PTEN: Messages from mutant mice

(2008) Akira Suzuki et al.   CANCER SCIENCE

Structural Basis of Membrane Invagination by F-BAR Domains

(2008) Adam Frost et al.   CELL

Pirt, a Phosphoinositide-Binding Protein, Functions as a Regulatory Subunit of TRPV1

(2008) Andrew Y. Kim et al.   CELL

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

TheLegionella pneumophilaphosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

(2008) Curdin Ragaz et al.   CELLULAR MICROBIOLOGY

Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes

(2008) Anne Fougerat et al.   CIRCULATION

Moving towards a Better Understanding of Chemotaxis

(2008) Len Stephens et al.   CURRENT BIOLOGY

An Expanded Biological Repertoire for Ins(3,4,5,6)P4 through its Modulation of ClC-3 Function

(2008) Jennifer Mitchell et al.   CURRENT BIOLOGY

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

Physiologic regulation of the epithelial sodium channel by phosphatidylinositides

(2008) Oleh Pochynyuk et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

Golgi Localization of Glycosyltransferases Requires a Vps74p Oligomer

(2008) Karl R. Schmitz et al.   DEVELOPMENTAL CELL

Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load

(2008) Hesso Farhan et al.   EMBO JOURNAL

Transient receptor potential channels meet phosphoinositides

(2008) Bernd Nilius et al.   EMBO JOURNAL

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse

(2008) Natsuko Jin et al.   EMBO JOURNAL

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS

The extreme C-terminal region of phospholipase Cβ1 determines subcellular localization and function; the “b” splice variant mediates α1-adrenergic receptor responses in cardiomyocytes

(2008) David R. Grubb et al.   FASEB JOURNAL

Involvement of nuclear PLCβ1 in lamin B1 phosphorylation and G2/M cell cycle progression

(2008) Roberta Fiume et al.   FASEB JOURNAL

Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate

(2008) Ken-ichi Otsuguro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MTMR9 Increases MTMR6 Enzyme Activity, Stability, and Role in Apoptosis

(2008) Jun Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Activation of the Nuclear Ubiquitin Ligase Cul3-SPOP by the Generation of Phosphatidylinositol 5-Phosphate

(2008) Matthew W. Bunce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase C-δ1Expression Is Linked to Proliferation, DNA Synthesis, and Cyclin E Levels

(2008) Jonathan D. Stallings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Activation of Phospholipase C-ϵ by Rho and Ras GTPases

(2008) Jason P. Seifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity of the Neuronal Cold Sensor TRPM8 Is Regulated by Phospholipase C via the Phospholipid Phosphoinositol 4,5-Bisphosphate

(2008) Richard L. Daniels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ci-VSP Is a Depolarization-activated Phosphatidylinositol-4,5-bisphosphate and Phosphatidylinositol-3,4,5-trisphosphate 5′-Phosphatase

(2008) Christian R. Halaszovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzyme Domain Affects the Movement of the Voltage Sensor in Ascidian and Zebrafish Voltage-sensing Phosphatases

(2008) Md. Israil Hossain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels

(2008) Baskaran Thyagarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissociation of Rac1(GDP)·RhoGDI Complexes by the Cooperative Action of Anionic Liposomes Containing Phosphatidylinositol 3,4,5-Trisphosphate, Rac Guanine Nucleotide Exchange Factor, and GTP

(2008) Yelena Ugolev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac Regulates Its Effector Phospholipase Cγ2through Interaction with a Split Pleckstrin Homology Domain

(2008) Claudia Walliser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein ofLegionella pneumophila

(2008) Eva Brombacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusion

(2008) Declan J. James et al.   JOURNAL OF CELL BIOLOGY

Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3

(2008) Dan Baird et al.   JOURNAL OF CELL BIOLOGY

Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1

(2008) Anastasia Blagoveshchenskaya et al.   JOURNAL OF CELL BIOLOGY

SopB promotes phosphatidylinositol 3-phosphate formation onSalmonellavacuoles by recruiting Rab5 and Vps34

(2008) Gustavo V. Mallo et al.   JOURNAL OF CELL BIOLOGY

Four key signaling pathways mediating chemotaxis inDictyostelium discoideum

(2008) Douwe M. Veltman et al.   JOURNAL OF CELL BIOLOGY

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

(2008) Phyllis I. Hanson et al.   JOURNAL OF CELL BIOLOGY

The regulation of cell motility and chemotaxis by phospholipid signaling

(2008) V. Kolsch et al.   JOURNAL OF CELL SCIENCE

Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor

(2008) N. Abe et al.   JOURNAL OF CELL SCIENCE

The multiple roles of PtdIns(4)P - not just the precursor of PtdIns(4,5)P2

(2008) G. D'Angelo et al.   JOURNAL OF CELL SCIENCE

Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes

(2008) D. Leonard et al.   JOURNAL OF CELL SCIENCE

Regulation of PLC 1a membrane anchoring by its substrate phosphatidylinositol (4,5)-bisphosphate

(2008) M. J. W. Adjobo-Hermans et al.   JOURNAL OF CELL SCIENCE

Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development

(2008) Sook-Young Yoon et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct Regulation of BK Channels by Phosphatidylinositol 4,5-Bisphosphate as a Novel Signaling Pathway

(2008) Thirumalini Vaithianathan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Plant phospholipid signaling: “in a nutshell”

(2008) Teun Munnik et al.   JOURNAL OF LIPID RESEARCH

ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality

(2008) Diego Sbrissa et al.   JOURNAL OF MOLECULAR BIOLOGY

Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions

(2008) L.-P. Bernier et al.   JOURNAL OF NEUROSCIENCE

Inhibition of native TRPC6 channel activity by phosphatidylinositol 4,5-bisphosphate in mesenteric artery myocytes

(2008) Anthony P. Albert et al.   JOURNAL OF PHYSIOLOGY-LONDON

Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes

(2008) Sohag N. Saleh et al.   JOURNAL OF PHYSIOLOGY-LONDON

The PI(3,5)P2 and PI(4,5)P2 Interactomes

(2008) Bruno Catimel et al.   JOURNAL OF PROTEOME RESEARCH

The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCβ

(2008) Mathilde A. Poussin et al.   MICROBIAL PATHOGENESIS

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased Insulin Action in SKIP Heterozygous Knockout Mice

(2008) T. Ijuin et al.   MOLECULAR AND CELLULAR BIOLOGY

PTEN Nuclear Localization Is Regulated by Oxidative Stress and Mediates p53-Dependent Tumor Suppression

(2008) C.-J. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Sac1 Phosphoinositide Phosphatase Regulates Golgi Membrane Morphology and Mitotic Spindle Organization in Mammals

(2008) Yang Liu et al.   MOLECULAR BIOLOGY OF THE CELL

The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit

(2008) Lars Demmel et al.   MOLECULAR BIOLOGY OF THE CELL

Diffusion Coefficient of Fluorescent Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane of Cells

(2008) Urszula Golebiewska et al.   MOLECULAR BIOLOGY OF THE CELL

Phosphatidylinositol-4-Kinase Type II Alpha Contains an AP-3–sorting Motif and a Kinase Domain That Are Both Required for Endosome Traffic

(2008) Branch Craige et al.   MOLECULAR BIOLOGY OF THE CELL

Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2α on Neurosecretory Vesicles

(2008) Peter J. Wen et al.   MOLECULAR BIOLOGY OF THE CELL

Nucleocytoplasmic Shuttling of the Golgi Phosphatidylinositol 4-Kinase Pik1 Is Regulated by 14-3-3 Proteins and Coordinates Golgi Function with Cell Growth

(2008) Lars Demmel et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking

(2008) Canhong Cao et al.   MOLECULAR BIOLOGY OF THE CELL

Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase

(2008) Roberto J. Botelho et al.   MOLECULAR BIOLOGY OF THE CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y-dependent Sorting Motifs in Different Pathways

(2008) Maribel Donoso et al.   MOLECULAR BIOLOGY OF THE CELL

Enteropathogenic Escherichia coli Subverts Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 3,4,5-Trisphosphate upon Epithelial Cell Infection

(2008) Hagit Sason et al.   MOLECULAR BIOLOGY OF THE CELL

General and Versatile Autoinhibition of PLC Isozymes

(2008) Stephanie N. Hicks et al.   MOLECULAR CELL

Functional Anatomy of Phospholipid Binding and Regulation of Phosphoinositide Homeostasis by Proteins of the Sec14 Superfamily

(2008) Gabriel Schaaf et al.   MOLECULAR CELL

Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: Myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain

(2008) Roberto Buccafusca et al.   MOLECULAR GENETICS AND METABOLISM

Phospholipase C Mediated Modulation of TRPV1 Channels

(2008) Tibor Rohacs et al.   MOLECULAR NEUROBIOLOGY

A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs

(2008) David L. Mellman et al.   NATURE

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking

(2008) Chengyu Liang et al.   NATURE CELL BIOLOGY

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

(2008) Bryan Heit et al.   NATURE IMMUNOLOGY

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

(2008) Jeffrey A Engelman et al.   NATURE MEDICINE

Putting super-resolution fluorescence microscopy to work

(2008) Jennifer Lippincott-Schwartz et al.   NATURE METHODS

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coordinated protein sorting, targeting and distribution in polarized cells

(2008) Ira Mellman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

(2008) C B Knobbe et al.   ONCOGENE

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

(2008) Mohamed Trebak et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

(2008) S. V. Voronov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice

(2008) F. L. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate

(2008) H. Iwasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

(2008) F. Fouladkou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of PIP5KI  demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTEN-deficient cancers depend on PIK3CB

(2008) S. Wee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling

Phagosome maturation during the removal of apoptotic cells: receptors lead the way

(2008) Zheng Zhou et al.   TRENDS IN CELL BIOLOGY

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate

(2007) Loïc Lemonnier et al.   CELL CALCIUM

Impact of Transgenic Overexpression of SH2-Containing Inositol 5′-Phosphatase 2 on Glucose Metabolism and Insulin Signaling in Mice

(2007) Syota Kagawa et al.   ENDOCRINOLOGY

Genotypes and phenotypes of Joubert syndrome and related disorders

(2007) Enza Maria Valente et al.   European Journal of Medical Genetics

Phospholipase C-δ1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development

(2007) Yoshikazu Nakamura et al.   FASEB JOURNAL

Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase IIIα

(2007) Andras Balla et al.   MOLECULAR BIOLOGY OF THE CELL

SNX9 Activities are Regulated by Multiple Phosphoinositides Through both PX and BAR Domains

(2007) Defne Yarar et al.   TRAFFIC