pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

(2016) J. M. Backer   BIOCHEMICAL JOURNAL

Phosphatidylinositol 3,5-bisphosphate: regulation of cellular events in space and time

(2016) N. Jin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments

(2016) Desirée C. Yang et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation

(2016) Cheuk Y. Ho et al.   Jove-Journal of Visualized Experiments

Lysosomal Physiology

(2015) Haoxing Xu et al.   Annual Review of Physiology

Phosphoinositides in phagocytosis and macropinocytosis

(2015) Roni Levin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phosphoinositides in endocytosis

(2015) York Posor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion

(2015) Yuxuan Miao et al.   CELL

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

(2015) M. J. Munson et al.   EMBO JOURNAL

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

(2015) Laura A. Stransky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PtdIns(4,5)P2and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance

(2015) Shiya Cheng et al.   JOURNAL OF CELL BIOLOGY

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

(2015) Andreas Jeschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes

(2015) K. Rostislavleva et al.   SCIENCE

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Eukaryotic V-ATPase: Novel structural findings and functional insights

(2014) Vladimir Marshansky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages

(2014) Grace H.E. Kim et al.   TRAFFIC

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling

(2013) Kay O. Schink et al.   BIOESSAYS

Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance

(2013) Amber J. McCartney et al.   BIOESSAYS

Phagocytosis Dynamics Depends on Target Shape

(2013) Debjani Paul et al.   BIOPHYSICAL JOURNAL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Filamentous morphology of bacteria delays the timing of phagosome morphogenesis in macrophages

(2013) Akriti Prashar et al.   JOURNAL OF CELL BIOLOGY

A model of lysosomal pH regulation

(2013) Yoichi Ishida et al.   JOURNAL OF GENERAL PHYSIOLOGY

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics

(2012) Kaoru Hazeki et al.   FEBS LETTERS

Phosphatidylinositol 3-kinases and their roles in phagosome maturation

(2012) E. P. Thi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Race to the Pole: How High-Aspect Ratio Shape and Heterogeneous Environments Limit Phagocytosis of Filamentous Escherichia coli Bacteria by Macrophages

(2012) Jens Möller et al.   NANO LETTERS

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How nascent phagosomes mature to become phagolysosomes

(2012) Gregory D. Fairn et al.   TRENDS IN IMMUNOLOGY

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Cytosolic H+microdomain developed around AE1 during AE1-mediated Cl−/HCO3−exchange

(2011) Danielle E. Johnson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phosphatidylinositol-3,5-Bisphosphate: No Longer the Poor PIP2

(2011) Cheuk Y. Ho et al.   TRAFFIC

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

TPC2 Is a Novel NAADP-sensitive Ca2+Release Channel, Operating as a Dual Sensor of Luminal pH and Ca2+

(2010) Samantha J. Pitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages

(2010) Scott B Berger et al.   NATURE IMMUNOLOGY

Macrophages Recognize Size and Shape of Their Targets

(2010) Nishit Doshi et al.   PLoS One

Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1)

(2010) A. Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Decoupling Internalization, Acidification and Phagosomal-Endosomal/lysosomal Fusion during Phagocytosis of InlA Coated Beads in Epithelial Cells

(2009) Craig D. Blanchette et al.   PLoS One

Membrane insertion of the FYVE domain is modulated by pH

(2009) Ju He et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Fc R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome

(2008) W. Tian et al.   BLOOD

Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking

(2008) Canhong Cao et al.   MOLECULAR BIOLOGY OF THE CELL

Phagosome maturation: going through the acid test

(2008) Jason M. Kinchen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shaping cups into phagosomes and macropinosomes

(2008) Joel A. Swanson   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Particle Size in Phagocytosis of Polymeric Microspheres

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH

Morphological plasticity as a bacterial survival strategy

(2007) Sheryl S. Justice et al.   NATURE REVIEWS MICROBIOLOGY