ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration

Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling

(2018) Christina M. McGuire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum

(2018) Maria Clara Guida et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in the X-linkedATP6AP2cause a glycosylation disorder with autophagic defects

(2017) Maria A. Rujano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration

(2015) Aline Dubos et al.   HUMAN MOLECULAR GENETICS

A splice site mutation in ATP6AP2 causes X-linked intellectual disability, epilepsy, and parkinsonism

(2015) Harsh V. Gupta et al.   PARKINSONISM & RELATED DISORDERS

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

Does bafilomycin A1block the fusion of autophagosomes with lysosomes?

(2014) Daniel J. Klionsky et al.   Autophagy

Intrinsically Active and Pacemaker Neurons in Pluripotent Stem Cell-Derived Neuronal Populations

(2014) Sebastian Illes et al.   Stem Cell Reports

XLID-Causing Mutations and Associated Genes Challenged in Light of Data From Large-Scale Human Exome Sequencing

(2013) Amélie Piton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Homotypic Vacuole Fusion in Yeast Requires Organelle Acidification and Not the V-ATPase Membrane Domain

(2013) Emily M. Coonrod et al.   DEVELOPMENTAL CELL

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)

(2013) Olena Korvatska et al.   HUMAN MOLECULAR GENETICS

Neuron-Specific (Pro)renin Receptor Knockout Prevents the Development of Salt-Sensitive Hypertension

(2013) Wencheng Li et al.   HYPERTENSION

The vesicular ATPase: A missing link between acidification and exocytosis

(2013) Dong Wang et al.   JOURNAL OF CELL BIOLOGY

Regulation of mTORC1 and its impact on gene expression at a glance

(2013) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Atp6ap2/(Pro)renin Receptor Interacts with Par3 as a Cell Polarity Determinant Required for Laminar Formation during Retinal Development in Mice

(2013) A. Kanda et al.   JOURNAL OF NEUROSCIENCE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Individual Domains and the Significance of Shedding of ATP6AP2/(pro)renin Receptor in Vacuolar H+-ATPase Biogenesis

(2013) Kenichiro Kinouchi et al.   PLoS One

Mature neurons: equipped for survival

(2013) A J Kole et al.   Cell Death & Disease

STED microscope with Spiral Phase Contrast

(2013) Marcel A. Lauterbach et al.   Scientific Reports

Involvement of tumor acidification in brain cancer pathophysiology

(2013) Avinash Honasoge et al.   Frontiers in Physiology

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Brain regions and genes affecting limb-clasping responses

(2011) R. Lalonde et al.   BRAIN RESEARCH REVIEWS

The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles

(2011) Bernd Strasser et al.   EMBO JOURNAL

Hyperactive behaviour in the mouse model of mucopolysaccharidosis IIIB in the open field and home cage environments

(2011) A. Langford-Smith et al.   GENES BRAIN AND BEHAVIOR

A Genetically Defined Morphologically and Functionally Unique Subset of 5-HT Neurons in the Mouse Raphe Nuclei

(2011) V. Kiyasova et al.   JOURNAL OF NEUROSCIENCE

Prorenin Receptor Is Essential for Normal Podocyte Structure and Function

(2011) Y. Oshima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prorenin Receptor Is Essential for Podocyte Autophagy and Survival

(2011) F. Riediger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes

(2010) Kenichiro Kinouchi et al.   CIRCULATION RESEARCH

A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism inDrosophila melanogasterphotoreceptors

(2010) W. Ryan Williamson et al.   JOURNAL OF CELL BIOLOGY

Autophagy: assays and artifacts

(2010) Sandra Barth et al.   JOURNAL OF PATHOLOGY

Physiology of the (pro)renin receptor: Wnt of change?

(2010) Gabin Sihn et al.   KIDNEY INTERNATIONAL

A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity

(2010) Parvoneh Poorkaj et al.   MOVEMENT DISORDERS

V-ATPase Membrane Sector Associates with Synaptobrevin to Modulate Neurotransmitter Release

(2010) Jérôme Di Giovanni et al.   NEURON

The Apical Complex Couples Cell Fate and Cell Survival to Cerebral Cortical Development

(2010) Seonhee Kim et al.   NEURON

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

The H+ Vacuolar ATPase Maintains Neural Stem Cells in the Developing Mouse Cortex

(2010) Christian Lange et al.   STEM CELLS AND DEVELOPMENT

A role of the (pro)renin receptor in neuronal cell differentiation

(2009) Aurelie Contrepas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma

(2009) Christelle Cousin et al.   HYPERTENSION

Human Splicing Finder: an online bioinformatics tool to predict splicing signals

(2009) François-Olivier Desmet et al.   NUCLEIC ACIDS RESEARCH

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

(2009) Stephen N. Sansom et al.   PLoS Genetics

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

(2008) Francesca Peri et al.   CELL

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Regulation of clathrin-mediated endocytosis by p53

(2008) Yoshie Endo et al.   GENES TO CELLS

An intrinsic mechanism of corticogenesis from embryonic stem cells

(2008) Nicolas Gaspard et al.   NATURE