Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency

New pieces in the complex puzzle of aberrant vacuolation. Focus on “Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency”

(2016) Loredana Saveanu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis

(2015) Ognian C. Ikonomov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole

(2015) Cheuk Y. Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methuosis

(2014) William A. Maltese et al.   AMERICAN JOURNAL OF PATHOLOGY

Plentiful PtdIns5P from scanty PtdIns(3,5)P2 or from ample PtdIns? PIKfyve-dependent models: Evidence and speculation (response to: DOI 10.1002/bies.201300012)

(2014) Assia Shisheva et al.   BIOESSAYS

RETRACTED: Vulnerability of Glioblastoma Cells to Catastrophic Vacuolization and Death Induced by a Small Molecule

(2014) Satish Srinivas Kitambi et al.   CELL

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

(2014) Sang H. Min et al.   Nature Communications

Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching

(2013) Ognian C. Ikonomov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PtdIns5P: News and views of its appearance, disappearance and deeds

(2013) Assia Shisheva   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling

(2013) Xinming Cai et al.   CHEMISTRY & BIOLOGY

Deletion of Autophagy-related 5 (Atg5) andPik3c3Genes in the Lens Causes Cataract Independent of Programmed Organelle Degradation

(2013) Hideaki Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis

(2013) W. Bechtel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

(2013) York Posor et al.   NATURE

Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

(2013) S. Takasuga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

(2012) Diego Sbrissa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation and cellular functions of class II phosphoinositide 3-kinases

(2012) Marco Falasca et al.   BIOCHEMICAL JOURNAL

Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1

(2012) Dave Bridges et al.   MOLECULAR BIOLOGY OF THE CELL

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development

(2011) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells

(2011) Jean H Overmeyer et al.   Molecular Cancer

Cation trapping by cellular acidic compartments: Beyond the concept of lysosomotropic drugs

(2011) François Marceau et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIKfyve-ArPIKfyve-Sac3 Core Complex

(2009) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIKfyve Regulation of Endosome-Linked Pathways

(2009) Jane de Lartigue et al.   TRAFFIC

Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3

(2008) Assia Shisheva   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PIKfyve: Partners, significance, debates and paradoxes

(2008) A SHISHEVA   CELL BIOLOGY INTERNATIONAL

A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding

(2008) Harold B J Jefferies et al.   EMBO REPORTS