Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Phosphatidylinositol-3,5-bisphosphate lipid-binding-induced activation of the human two-pore channel 2
Authors
Keywords
Electrophysiology, Homology model, Ion channel, Ligand-binding, Molecular dynamics simulation, Site-directed mutagenesis
Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2018-04-28
DOI
10.1007/s00018-018-2829-5
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Tuning the ion selectivity of two-pore channels
- (2017) Jiangtao Guo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The human two-pore channel 1 is modulated by cytosolic and luminal calcium
- (2017) Laura Lagostena et al. Scientific Reports
- Allosterism and Structure in Thermally Activated Transient Receptor Potential Channels
- (2016) Ignacio Diaz-Franulic et al. Annual Review of Biophysics
- The function of the two-pore channel TPC1 depends on dimerization of its carboxy-terminal helix
- (2016) Nina Larisch et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- A Critical Comparison of Biomembrane Force Fields: Structure and Dynamics of Model DMPC, POPC, and POPE Bilayers
- (2016) Kristyna Pluhackova et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Structure, inhibition and regulation of two-pore channel TPC1 from Arabidopsis thaliana
- (2016) Alexander F. Kintzer et al. NATURE
- Lysosomal Physiology
- (2015) Haoxing Xu et al. Annual Review of Physiology
- Lipid agonism: The PIP2 paradigm of ligand-gated ion channels
- (2015) Scott B. Hansen BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Phosphoinositides regulate ion channels
- (2015) Bertil Hille et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
- (2015) M. Ruas et al. EMBO JOURNAL
- Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations
- (2015) Tsjerk A. Wassenaar et al. Journal of Chemical Theory and Computation
- Biomembranes in atomistic and coarse-grained simulations
- (2015) Kristyna Pluhackova et al. JOURNAL OF PHYSICS-CONDENSED MATTER
- Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana
- (2015) Jiangtao Guo et al. NATURE
- Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
- (2015) Yasuteru Sakurai et al. SCIENCE
- Assessing the local structural quality of transmembrane protein models using statistical potentials (QMEANBrane)
- (2014) Gabriel Studer et al. BIOINFORMATICS
- The phosphoinositide PI(3,5)P2 mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells
- (2014) Anna Boccaccio et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- The voltage-gated sodium channel TPC1 confers endolysosomal excitability
- (2014) Chunlei Cang et al. Nature Chemical Biology
- SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information
- (2014) Marco Biasini et al. NUCLEIC ACIDS RESEARCH
- VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling
- (2014) A. Favia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
- (2014) Christian Grimm et al. Nature Communications
- A non-inactivating high-voltage-activated two-pore Na+ channel that supports ultra-long action potentials and membrane bistability
- (2014) Chunlei Cang et al. Nature Communications
- mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State
- (2013) Chunlei Cang et al. CELL
- Martini Force Field Parameters for Glycolipids
- (2013) César A. López et al. Journal of Chemical Theory and Computation
- Going Backward: A Flexible Geometric Approach to Reverse Transformation from Coarse Grained to Atomistic Models
- (2013) Tsjerk A. Wassenaar et al. Journal of Chemical Theory and Computation
- Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics
- (2013) X. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating
- (2013) Q. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes
- (2012) Xiang Wang et al. CELL
- Improved Parameters for the Martini Coarse-Grained Protein Force Field
- (2012) Djurre H. de Jong et al. Journal of Chemical Theory and Computation
- Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles
- (2012) Robert B. Best et al. Journal of Chemical Theory and Computation
- TheArabidopsiscentral vacuole as an expression system for intracellular transporters: functional characterization of the Cl−/H+exchanger CLC-7
- (2012) Alex Costa et al. JOURNAL OF PHYSIOLOGY-LONDON
- PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker
- (2012) A. A. Rodriguez-Menchaca et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An N-Terminal Dileucine Motif Directs Two-Pore Channels to the Tonoplast of Plant Cells
- (2012) Nina Larisch et al. TRAFFIC
- Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium
- (2011) Matthew R. Whorton et al. CELL
- CHARMM Additive All-Atom Force Field for Phosphate and Sulfate Linked to Carbohydrates
- (2011) Sairam S. Mallajosyula et al. Journal of Chemical Theory and Computation
- TPC1 – SV Channels Gain Shape
- (2011) Rainer Hedrich et al. Molecular Plant
- Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega
- (2011) F. Sievers et al. Molecular Systems Biology
- Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2
- (2011) Scott B. Hansen et al. NATURE
- Differential contribution of EF-hands to the Ca2+-dependent activation in the plant two-pore channel TPC1
- (2011) Christina Schulze et al. PLANT JOURNAL
- Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective
- (2010) Nicolas Guex et al. ELECTROPHORESIS
- Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types
- (2010) Jeffery B. Klauda et al. JOURNAL OF PHYSICAL CHEMISTRY B
- PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
- (2010) Xian-ping Dong et al. Nature Communications
- Polarizable Water Model for the Coarse-Grained MARTINI Force Field
- (2010) Semen O. Yesylevskyy et al. PLoS Computational Biology
- Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies
- (2009) Oded Edelheit et al. BMC BIOTECHNOLOGY
- An Ancestral Deuterostome Family of Two-pore Channels Mediates Nicotinic Acid Adenine Dinucleotide Phosphate-dependent Calcium Release from Acidic Organelles
- (2009) Eugen Brailoiu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CHARMM Additive All-Atom Force Field for Acyclic Polyalcohols, Acyclic Carbohydrates, and Inositol
- (2009) Elizabeth R. Hatcher et al. Journal of Chemical Theory and Computation
- NAADP mobilizes calcium from acidic organelles through two-pore channels
- (2009) Peter J. Calcraft et al. NATURE
- The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores
- (2009) Xiangang Zong et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
- (2008) Byung-Chang Suh et al. Annual Review of Biophysics
- Kinetics, Statistics, and Energetics of Lipid Membrane Electroporation Studied by Molecular Dynamics Simulations
- (2008) Rainer A. Böckmann et al. BIOPHYSICAL JOURNAL
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- The SWISS-MODEL Repository and associated resources
- (2008) F. Kiefer et al. NUCLEIC ACIDS RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started