The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases

Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification

(2019) Mümine Şentürk et al.   NATURE CELL BIOLOGY

LRRK2 interacts with the vacuolar-type H+-ATPase pump a1 subunit to regulate lysosomal function

(2019) Rebecca Wallings et al.   HUMAN MOLECULAR GENETICS

ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration

(2019) Takuo Hirose et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactobacillus frumenti improves antioxidant capacity via nitric oxide synthase 1 in intestinal epithelial cells

(2019) Yangfan Nie et al.   FASEB JOURNAL

A subunit of V-ATPases, ATP6V1B2, underlies the pathology of intellectual disability

(2019) Weihao Zhao et al.   EBioMedicine

A novel role of UBQLNs (ubiquilins) in regulating autophagy, MTOR signaling and v-ATPase function

(2019) Ying Yang et al.   Autophagy

Lysosomes as dynamic regulators of cell and organismal homeostasis

(2019) Andrea Ballabio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

(2019) King Faisal Yambire et al.   eLife

Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals

(2018) Eugene Jennifer Jin et al.   CURRENT BIOLOGY

ATP6V0A2 -related cutis laxa in ten novel patients: focus on clinical variability and expansion of the phenotype

(2018) Aude Beyens et al.   EXPERIMENTAL DERMATOLOGY

A lysosomal proton pump turns on when glucose runs out

(2018) Karlett J. Parra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose starvation increases V-ATPase assembly and activity in mammalian cells through AMP kinase and phosphatidylinositide 3-kinase/Akt signaling

(2018) Christina M. McGuire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosome trafficking and signaling in health and neurodegenerative diseases

(2018) Pearl P.Y. Lie et al.   NEUROBIOLOGY OF DISEASE

Neuronal lysosomes

(2018) Shawn M. Ferguson   NEUROSCIENCE LETTERS

Assembling the mitochondrial ATP synthase

(2018) Jiyao Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling

(2018) Ira Milosevic   Frontiers in Cellular Neuroscience

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

(2018) Zohreh Farsi et al.   eLife

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

(2018) Barry Boland et al.   NATURE REVIEWS DRUG DISCOVERY

Harnessing Lysosomal pH through PLGA Nanoemulsion as a Treatment of Lysosomal-Related Neurodegenerative Diseases

(2018) Geoffrey Prévot et al.   BIOCONJUGATE CHEMISTRY

ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function

(2017) S. Demirsoy et al.   HUMAN MOLECULAR GENETICS

Molecular mechanisms of developmentally programmed crinophagy inDrosophila

(2017) Tamás Csizmadia et al.   JOURNAL OF CELL BIOLOGY

Mutations in the X-linkedATP6AP2cause a glycosylation disorder with autophagic defects

(2017) Maria A. Rujano et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

(2017) Maria B. Bagh et al.   Nature Communications

The genetic background of Parkinson's disease: current progress and future prospects

(2016) K. Kalinderi et al.   ACTA NEUROLOGICA SCANDINAVICA

The crucial impact of lysosomes in aging and longevity

(2016) Didac Carmona-Gutierrez et al.   AGEING RESEARCH REVIEWS

Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases

(2016) Mathieu Bourdenx et al.   Autophagy

Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes

(2016) Gina A. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms and functions of lysosome positioning

(2016) Jing Pu et al.   JOURNAL OF CELL SCIENCE

Compartment-Specific Regulation of Autophagy in Primary Neurons

(2016) Sandra Maday et al.   JOURNAL OF NEUROSCIENCE

FK506, an Immunosuppressive Drug, Induces Autophagy by Binding to the V-ATPase Catalytic Subunit A in Neuronal Cells

(2016) Dongyoung Kim et al.   JOURNAL OF PROTEOME RESEARCH

Renin-angiotensin system gene expression and neurodegenerative diseases

(2016) B. Goldstein et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation

(2016) Eric J. R. Jansen et al.   Nature Communications

NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease

(2016) Rituraj Pal et al.   Scientific Reports

Mechanisms of Aβ Clearance and Degradation by Glial Cells

(2016) Miriam Ries et al.   Frontiers in Aging Neuroscience

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

Genetics of the neuronal ceroid lipofuscinoses (Batten disease)

(2015) Sara E. Mole et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration

(2015) Aline Dubos et al.   HUMAN MOLECULAR GENETICS

Organelle autoregulation--stress responses in the ER, Golgi, mitochondria and lysosome

(2015) K. Sasaki et al.   JOURNAL OF BIOCHEMISTRY

Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly

(2015) Laura A. Stransky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

(2015) L. R. Kett et al.   JOURNAL OF NEUROSCIENCE

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome

(2015) Fanny Kortüm et al.   NATURE GENETICS

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

A splice site mutation in ATP6AP2 causes X-linked intellectual disability, epilepsy, and parkinsonism

(2015) Harsh V. Gupta et al.   PARKINSONISM & RELATED DISORDERS

Recent Insights into the Structure, Regulation, and Function of the V-ATPases

(2015) Kristina Cotter et al.   TRENDS IN BIOCHEMICAL SCIENCES

Autophagy in Huntington disease and huntingtin in autophagy

(2015) Dale D.O. Martin et al.   TRENDS IN NEUROSCIENCES

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

(2015) Yong-Bo Hu et al.   Translational Neurodegeneration

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

(2014) Sandra Maday et al.   DEVELOPMENTAL CELL

Novel techniques in the development of osteoporosis drug therapy: the osteoclast ruffled-border vacuolar H+-ATPase as an emerging target

(2014) Norbert Kartner et al.   Expert Opinion on Drug Discovery

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

(2014) Jose Bras et al.   HUMAN MOLECULAR GENETICS

A new life for an old pump: V-ATPase and neurotransmitter release

(2014) Stefano Vavassori et al.   JOURNAL OF CELL BIOLOGY

Autophagy in the endocrine glands

(2014) Andrea Weckman et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease

(2014) Leandra R. Mangieri et al.   PLoS One

Endosomal pH in neuronal signaling and synaptic transmission: role of Na+/H+ exchanger NHE5

(2014) Graham H. Diering et al.   Frontiers in Physiology

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

(2013) Patrick J. Schultheis et al.   HUMAN MOLECULAR GENETICS

Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)

(2013) Olena Korvatska et al.   HUMAN MOLECULAR GENETICS

Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes

(2013) Javier Pacheco-Quinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The V-ATPase membrane domain is a sensor of granular pH that controls the exocytotic machinery

(2013) Sandrine Poëa-Guyon et al.   JOURNAL OF CELL BIOLOGY

The genetics of Parkinson's disease: Progress and therapeutic implications

(2013) Andrew B. Singleton et al.   MOVEMENT DISORDERS

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease

(2012) Fabio Di Domenico et al.   ANTIOXIDANTS & REDOX SIGNALING

An update in the structure, function, and regulation of V-ATPases: the role of the C subunit

(2012) M Pérez-Sayáns et al.   BRAZILIAN JOURNAL OF BIOLOGY

Membrane trafficking in neuronal maintenance and degeneration

(2012) Dong Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting Reversible Disassembly as a Mechanism of Controlling V-ATPase Activity

(2012) Patricia M. Kane   CURRENT PROTEIN & PEPTIDE SCIENCE

Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear

(2012) B. Lorente-Canovas et al.   Disease Models & Mechanisms

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule

(2012) J. Christopher Hennings et al.   EMBO Molecular Medicine

Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability

(2012) S. Gharanei et al.   HUMAN MOLECULAR GENETICS

Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis

(2012) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Osteopetrosis Mutation R444L Causes Endoplasmic Reticulum Retention and Misprocessing of Vacuolar H+-ATPasea3Subunit

(2012) Ajay Bhargava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Domains within the V-ATPase Accessory Subunit Ac45 Involved in V-ATPase Transport and Ca2+-dependent Exocytosis

(2012) Eric J. R. Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor-induced Vacuolar (H+)-ATPase Assembly

(2012) Yanqing Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

(2012) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocerebrosidase Involvement in Parkinson Disease and Other Synucleinopathies

(2012) Maria do Rosário Almeida   Frontiers in Neurology

Neurotransmitter Corelease: Mechanism and Physiological Role

(2011) Thomas S. Hnasko et al.   Annual Review of Physiology

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Increased risk of Parkinson's disease in individuals hospitalized with conditions related to the use of methamphetamine or other amphetamine-type drugs

(2011) Russell C. Callaghan et al.   DRUG AND ALCOHOL DEPENDENCE

Regulation of TFEB and V-ATPases by mTORC1

(2011) Samuel Peña-Llopis et al.   EMBO JOURNAL

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Functional characterization of (pro)renin receptor in association with V-ATPase

(2011) Kenichiro Kinouchi   Frontiers in Bioscience-Landmark

Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic  -cells

(2011) M. Hatanaka et al.   HUMAN MOLECULAR GENETICS

Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

(2011) Jin-Sung Park et al.   HUMAN MUTATION

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells

(2011) T. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

From glutamate co-release to vesicular synergy: vesicular glutamate transporters

(2011) Salah El Mestikawy et al.   NATURE REVIEWS NEUROSCIENCE

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes

(2010) Kenichiro Kinouchi et al.   CIRCULATION RESEARCH

Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy

(2010) Enrico P Spugnini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

An Extended Nomenclature for Mammalian V-ATPase Subunit Genes and Splice Variants

(2010) Kevin C. Miranda et al.   PLoS One

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Vacuolar H+-ATPase meets glycosylation in patients with cutis laxa

(2009) Mailys Guillard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cellular physiology of the renal H+ATPase

(2009) Katherine G Blake-Palmer et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

(2009) Yan Yan et al.   DEVELOPMENTAL CELL

Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins

(2009) J. A. Sobota et al.   JOURNAL OF CELL SCIENCE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Accessory subunit Ac45 controls the V-ATPase in the regulated secretory pathway

(2008) Eric J.R. Jansen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE