Mechanisms and functions of lysosome positioning

Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with alteredcis-regulation ofBORCS7,AS3MT, andNT5C2in the human brain

(2016) Rodrigo R. R. Duarte et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Brain Disorders Due to Lysosomal Dysfunction

(2016) Alessandro Fraldi et al.   Annual Review of Neuroscience

ER–endosome contact sites in endosome positioning and protrusion outgrowth

(2016) Camilla Raiborg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity

(2016) Josta T. Kevenaar et al.   CURRENT BIOLOGY

Kinesin 1 Drives Autolysosome Tubulation

(2016) Wanqing Du et al.   DEVELOPMENTAL CELL

Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites

(2016) J. Lipka et al.   EMBO JOURNAL

The awesome lysosome

(2016) A. Ballabio   EMBO Molecular Medicine

Folliculin directs the formation of a Rab34–RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes

(2016) Georgina P Starling et al.   EMBO REPORTS

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair

(2016) Marisa Encarnação et al.   JOURNAL OF CELL BIOLOGY

Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation

(2016) K. W. Yau et al.   JOURNAL OF NEUROSCIENCE

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

(2016) Amra Saric et al.   MOLECULAR BIOLOGY OF THE CELL

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

(2016) Ming Li et al.   NATURE MEDICINE

The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo

(2016) Samantha S. Dykes et al.   Oncotarget

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

(2016) Magdalena L. Circu et al.   PLoS One

Lysosomal Storage Diseases: From Pathophysiology to Therapy

(2015) Giancarlo Parenti et al.   Annual Review of Medicine

Cholesterol Transport through Lysosome-Peroxisome Membrane Contacts

(2015) Bei-Bei Chu et al.   CELL

BORC, a Multisubunit Complex that Regulates Lysosome Positioning

(2015) Jing Pu et al.   DEVELOPMENTAL CELL

Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease

(2015) Christine Erie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Overexpression ofKLC2due to a homozygous deletion in the non-coding region causes SPOAN syndrome

(2015) Uirá S. Melo et al.   HUMAN MOLECULAR GENETICS

A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations

(2015) Marvin Bentley et al.   JOURNAL OF CELL BIOLOGY

Failure of lysosome clustering and positioning in the juxtanuclear region in cells deficient in rapsyn

(2015) M. Aittaleb et al.   JOURNAL OF CELL SCIENCE

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

(2015) Vanessa M. D’Costa et al.   Cell Reports

The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration

(2014) Natalia Schiefermeier et al.   JOURNAL OF CELL BIOLOGY

CLIC3 controls recycling of late endosomal MT1-MMP and dictates invasion and metastasis in breast cancer

(2014) I. R. Macpherson et al.   JOURNAL OF CELL SCIENCE

Proteasome Failure Promotes Positioning of Lysosomes around the Aggresome via Local Block of Microtubule-Dependent Transport

(2014) N. Zaarur et al.   MOLECULAR AND CELLULAR BIOLOGY

Supporting a Role for the GTPase Rab7 in Prostate Cancer Progression

(2014) Joshua J. Steffan et al.   PLoS One

Crystal Structure of the Rab9A-RUTBC2 RBD Complex Reveals the Molecular Basis for the Binding Specificity of Rab9A with RUTBC2

(2014) Zhe Zhang et al.   STRUCTURE

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

(2013) K. Krzewski et al.   BLOOD

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

(2013) Benjamin M. Schwenk et al.   EMBO JOURNAL

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

(2013) Pedro Monteiro et al.   JOURNAL OF CELL BIOLOGY

Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity

(2013) Amit Tuli et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

(2013) Karine Poirier et al.   NATURE GENETICS

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Terminal transport of lytic granules to the immune synapse is mediated by the kinesin-1/Slp3/Rab27a complex

(2012) M. Kurowska et al.   BLOOD

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments

(2012) Kristiina Uusi-Rauva et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagic lysosome reformation

(2012) Yang Chen et al.   EXPERIMENTAL CELL RESEARCH

RUTBC2 Protein, a Rab9A Effector and GTPase-activating Protein for Rab36

(2012) Ryan M. Nottingham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural biology of cytoplasmic and axonemal dyneins

(2012) Takashi Ishikawa   JOURNAL OF STRUCTURAL BIOLOGY

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Salmonella Inhibits Retrograde Trafficking of Mannose-6-Phosphate Receptors and Lysosome Function

(2012) K. McGourty et al.   SCIENCE

Rab7 and Arl8 GTPases are Necessary for Lysosome Tubulation in Macrophages

(2012) Amra Mrakovic et al.   TRAFFIC

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

(2011) M. W. Dodson et al.   HUMAN MOLECULAR GENETICS

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport

(2011) Takao Nakata et al.   JOURNAL OF CELL BIOLOGY

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

(2011) Fumiko Matsuzaki et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Transient binding of dynein controls bidirectional long-range motility of early endosomes

(2011) Martin Schuster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

A Role for Rab7 in the Movement of Secretory Granules in Cytotoxic T Lymphocytes

(2011) Tiziana Daniele et al.   TRAFFIC

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence

(2010) Eigen R. Peralta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

(2010) Juliane P. Caviston et al.   MOLECULAR BIOLOGY OF THE CELL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Snapin-Regulated Late Endosomal Transport Is Critical for Efficient Autophagy-Lysosomal Function in Neurons

(2010) Qian Cai et al.   NEURON

SKIP, the Host Target of the Salmonella Virulence Factor SifA, Promotes Kinesin-1-Dependent Vacuolar Membrane Exchanges

(2010) Audrey Dumont et al.   TRAFFIC

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Tubulin tyrosination navigates the kinesin-1 motor domain to axons

(2009) Yoshiyuki Konishi et al.   NATURE NEUROSCIENCE

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

(2009) Carla M. P. Cardoso et al.   PLoS One

Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors

(2009) Dawen Cai et al.   PLOS BIOLOGY

Conventional Kinesin Holoenzymes Are Composed of Heavy and Light Chain Homodimers†

(2008) Scott R. DeBoer et al.   BIOCHEMISTRY

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

(2008) Shunsuke Kimura et al.   CELL STRUCTURE AND FUNCTION

Tubulin modifications and their cellular functions

(2008) Jennetta W Hammond et al.   CURRENT OPINION IN CELL BIOLOGY

Drosophila Ensconsin Promotes Productive Recruitment of Kinesin-1 to Microtubules

(2008) Hsin-Ho Sung et al.   DEVELOPMENTAL CELL

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

(2008) S. Dunn et al.   JOURNAL OF CELL SCIENCE

Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics

(2008) Nobutaka Hirokawa et al.   PHYSIOLOGICAL REVIEWS

The Salmonella virulence protein SifA is a G protein antagonist

(2008) L. K. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Different Microtubule Motors Move Early and Late Endocytic Compartments

(2008) Sylvain Loubéry et al.   TRAFFIC