Ageing, metabolism and the intestine

LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate

(2020) Yajing Gao et al.   GASTROENTEROLOGY

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

(2020) Dan He et al.   Nature Communications

A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila

(2020) Fillip Port et al.   eLife

An intestinal zinc sensor regulates food intake and developmental growth

(2020) Siamak Redhai et al.   NATURE

JNK-dependent intestinal barrier failure disrupts host–microbe homeostasis during tumorigenesis

(2020) Jun Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster

(2019) Nga N. Nguyen et al.   Scientific Reports

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

(2019) Bruno Sovran et al.   Scientific Reports

Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction

(2019) Imilce A. Rodriguez-Fernandez et al.   Nature Communications

Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production

(2019) T. M. Zaved Waise et al.   Nature Communications

Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells

(2019) Hui Cui et al.   Stem Cell Reviews and Reports

Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila

(2019) Paula Juricic et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The autophagy-related gene Atg101 in Drosophila regulates both neuron and midgut homeostasis

(2019) Ting Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

(2019) Joel Johansson et al.   Cell Stem Cell

NAD + supplementation rejuvenates aged gut adult stem cells

(2019) Masaki Igarashi et al.   AGING CELL

An SH3PX1-Dependent Endocytosis-Autophagy Network Restrains Intestinal Stem Cell Proliferation by Counteracting EGFR-ERK Signaling

(2019) Peng Zhang et al.   DEVELOPMENTAL CELL

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell

(2019) Arshad Ayyaz et al.   NATURE

Advanced age promotes colonic dysfunction and gut‐derived lung infection after stroke

(2019) Shu Wen Wen et al.   AGING CELL

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

(2019) Nalle Pentinmikko et al.   NATURE

Transcriptome analysis identifies a robust gene expression program in the mouse intestinal epithelium on aging

(2019) Juri Kazakevych et al.   Scientific Reports

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

(2019) Andrey A. Parkhitko et al.   AGING CELL

The Microbiome and Aging

(2019) Bianca Bana et al.   Annual Review of Genetics

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

(2019) Rosina Pryor et al.   CELL

Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity

(2019) Daniel Jun-Kit Hu et al.   Cell Reports

Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism

(2019) Dona R. Wisidagama et al.   G3-Genes Genomes Genetics

The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila

(2019) Junmeng Xi et al.   Aging-US

Damage sensing by a Nox-Ask1-MKK3-p38 signaling pathway mediates regeneration in the adult Drosophila midgut

(2019) Parthive H. Patel et al.   Nature Communications

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

(2019) Evandro F. Fang et al.   Nature Communications

Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut

(2019) Hubing Ma et al.   Biology Open

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis

(2018) Bo Wang et al.   Cell Stem Cell

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

(2018) Maria M. Mihaylova et al.   Cell Stem Cell

Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

(2018) James H. Catterson et al.   CURRENT BIOLOGY

Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

(2018) Qi Li et al.   DEVELOPMENTAL CELL

Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine

(2018) Fumiaki Obata et al.   DEVELOPMENTAL CELL

Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila

(2018) Martin Resnik-Docampo et al.   FLY

Effect of heterochromatin stability on intestinal stem cell aging in Drosophila

(2018) Ho-Jun Jeon et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Drosophila Peptide Hormones Allatostatin A and Diuretic Hormone 31 Exhibiting Complementary Gradient Distribution in Posterior Midgut Antagonistically Regulate Midgut Senescence and Adult Lifespan

(2018) Koji Takeda et al.   ZOOLOGICAL SCIENCE

Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells

(2018) Maryam Yousefi et al.   Stem Cell Reports

The Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis in Intestinal Epithelial Cells Regulates Intestinal Barrier Function During Intestinal Epithelial Cells–CD4+T-Cell Interactions

(2018) Tanzhou Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Stem Cell Intrinsic Hexosamine Metabolism Regulates Intestinal Adaptation to Nutrient Content

(2018) Jaakko Mattila et al.   DEVELOPMENTAL CELL

Dietary Lipids Modulate Notch Signaling and Influence Adult Intestinal Development and Metabolism in Drosophila

(2018) Rebecca Obniski et al.   DEVELOPMENTAL CELL

Linoorbitides and enterolactone mitigate inflammation-induced oxidative stress and loss of intestinal epithelial barrier integrity

(2018) Ahmed A. Almousa et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

(2018) Timo E. S. Kauppila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy maintains stem cells and intestinal homeostasis in Drosophila

(2018) Péter Nagy et al.   Scientific Reports

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

(2018) Clea Bárcena et al.   Cell Reports

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

(2018) Kurt A. Escobar et al.   AGING CELL

Intestinal renewal across the animal kingdom: comparing stem cell activity in mouse and Drosophila

(2018) Rachel K. Zwick et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila

(2018) Alessandro Scopelliti et al.   Cell Metabolism

Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster

(2018) Irene Miguel-Aliaga et al.   GENETICS

Tales from the crypt: new insights into intestinal stem cells

(2018) Helmuth Gehart et al.   Nature Reviews Gastroenterology & Hepatology

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

(2018) Kazutaka Akagi et al.   PLoS Genetics

Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota

(2017) Alicia S. Wellman et al.   GASTROENTEROLOGY

Loss of the mucosal barrier alters the progenitor cell niche via Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling

(2017) Liping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging

(2017) Christopher L. Koehler et al.   JOURNAL OF CELL BIOLOGY

Myosin Light Chain Kinase Knockout Improves Gut Barrier Function and Confers a Survival Advantage in Polymicrobial Sepsis

(2017) C Adam Lorentz et al.   MOLECULAR MEDICINE

A proteomic atlas of insulin signalling reveals tissue‐specific mechanisms of longevity assurance

(2017) Luke S Tain et al.   Molecular Systems Biology

RNA polymerase III limits longevity downstream of TORC1

(2017) Danny Filer et al.   NATURE

Feedback regulation of steady-state epithelial turnover and organ size

(2017) Jackson Liang et al.   NATURE

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism

(2017) John C. Schell et al.   NATURE CELL BIOLOGY

Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila

(2017) Ayako Kohyama-Koganeya et al.   PLoS One

Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model

(2017) Wei Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration

(2017) Jun Zhou et al.   Nature Communications

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster

(2017) Anil Rana et al.   Nature Communications

Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth

(2017) Arthur Luhur et al.   Cell Reports

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity

(2017) Ekin Bolukbasi et al.   Cell Reports

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

(2017) Pedro Sousa-Victor et al.   Cell Reports

A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila

(2017) Zongzhao Zhai et al.   PLoS Genetics

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

(2017) Martin Borch Jensen et al.   eLife

Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury

(2016) Younggeon Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice

(2016) Hina Mir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

The ageing gastrointestinal tract

(2016) Stijn Soenen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Maintenance of the adult Drosophila intestine: all roads lead to homeostasis

(2016) Zheng Guo et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Regulation and plasticity of intestinal stem cells during homeostasis and regeneration

(2016) Joep Beumer et al.   DEVELOPMENT

mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice

(2016) Leesa L. Sampson et al.   FASEB JOURNAL

A subset of enteroendocrine cells is activated by amino acids in theDrosophilamidgut

(2016) Jeong-Ho Park et al.   FEBS LETTERS

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span inDrosophila

(2016) Andrey A. Parkhitko et al.   GENES & DEVELOPMENT

4E-BP is a target of the GCN2–ATF4 pathway duringDrosophiladevelopment and aging

(2016) Min-Ji Kang et al.   JOURNAL OF CELL BIOLOGY

Reduced intestinal motility, mucosal barrier function, and inflammation in aged monkeys

(2016) E. L. Mitchell et al.   Journal of Nutrition Health & Aging

Defining a stem cell hierarchy in the intestine: markers, caveats and controversies

(2016) Nicholas R. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunction

(2016) Márton Kiss et al.   MATRIX BIOLOGY

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila

(2016) Shree Ram Singh et al.   NATURE

Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis

(2016) Martin Resnik-Docampo et al.   NATURE CELL BIOLOGY

The Hippo pathway in intestinal regeneration and disease

(2016) Audrey W. Hong et al.   Nature Reviews Gastroenterology & Hepatology

Mechanisms of Intestinal Barrier Dysfunction in Sepsis

(2016) Benyam P. Yoseph et al.   SHOCK

Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice

(2016) Paul Essers et al.   Scientific Reports

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction

(2016) Nuno Miguel Luis et al.   Cell Reports

Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis

(2016) Tomas Valenta et al.   Cell Reports

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

(2016) Jennifer C Regan et al.   eLife

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

(2015) Katarzyna Siudeja et al.   Cell Stem Cell

Lin-28 promotes symmetric stem cell division and drives adaptive growth in the adultDrosophilaintestine

(2015) Ching-Huan Chen et al.   DEVELOPMENT

Dpp/Gbb signaling is required for normal intestinal regeneration during infection

(2015) Jun Zhou et al.   DEVELOPMENTAL BIOLOGY

The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila

(2015) Sunitha Byri et al.   DEVELOPMENTAL CELL

Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging

(2015) Joana Neves et al.   DEVELOPMENTAL CELL

How informative is the mouse for human gut microbiota research?

(2015) T. L. A. Nguyen et al.   Disease Models & Mechanisms

Starving for more: Nutrient sensing by LIN-28 in adult intestinal progenitor cells

(2015) Arthur Luhur et al.   FLY

Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

(2015) Alex Gregorieff et al.   NATURE

Signal integration by Ca2+ regulates intestinal stem-cell activity

(2015) Hansong Deng et al.   NATURE

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan

(2015) Fumiaki Obata et al.   Nature Communications

Rapamycin preserves gut homeostasis during Drosophila aging

(2015) Xiaolan Fan et al.   Oncotarget

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

Regional Cell-Specific Transcriptome Mapping Reveals Regulatory Complexity in the Adult Drosophila Midgut

(2015) Devanjali Dutta et al.   Cell Reports

Age-associated changes of the intestinal epithelial barrier: local and systemic implications

(2015) Claudio Nicoletti   Expert Review of Gastroenterology & Hepatology

EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

(2015) Yinhua Jin et al.   PLoS Genetics

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

Crosslinking of a Peritrophic Matrix Protein Protects Gut Epithelia from Bacterial Exotoxins

(2015) Toshio Shibata et al.   PLoS Pathogens

Differential Effects of Tissue-Specific Deletion of BOSS on Feeding Behaviors and Energy Metabolism

(2015) Ayako Kohyama-Koganeya et al.   PLoS One

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

(2014) Z. Kabiri et al.   DEVELOPMENT

Impact of Diet-Induced Obesity on Intestinal Stem Cells: Hyperproliferation but Impaired Intrinsic Function That Requires Insulin/IGF1

(2014) Amanda T. Mah et al.   ENDOCRINOLOGY

Nutrient control of Drosophila longevity

(2014) Marc Tatar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner

(2014) Matthew Ulgherait et al.   Cell Reports

Transforming Growth Factor β/Activin Signaling Functions as a Sugar-Sensing Feedback Loop to Regulate Digestive Enzyme Expression

(2014) Wen-bin Alfred Chng et al.   Cell Reports

Enteroendocrine Cells Support Intestinal Stem-Cell-Mediated Homeostasis in Drosophila

(2014) Alla Amcheslavsky et al.   Cell Reports

Control of Lipid Metabolism by Tachykinin in Drosophila

(2014) Wei Song et al.   Cell Reports

Integration of UPRER and Oxidative Stress Signaling in the Control of Intestinal Stem Cell Proliferation

(2014) Lifen Wang et al.   PLoS Genetics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Bacterial Nitric Oxide Extends the Lifespan of C. elegans

(2013) Ivan Gusarov et al.   CELL

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Continuous Clonal Labeling Reveals Small Numbers of Functional Stem Cells in Intestinal Crypts and Adenomas

(2013) Sarah Kozar et al.   Cell Stem Cell

TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis

(2013) Liping Su et al.   GASTROENTEROLOGY

Injury-induced BMP signaling negatively regulatesDrosophilamidgut homeostasis

(2013) Zheng Guo et al.   JOURNAL OF CELL BIOLOGY

Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis

(2013) Iris Augustin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genotype to phenotype: lessons from model organisms for human genetics

(2013) Ben Lehner   NATURE REVIEWS GENETICS

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

(2013) Nicolas Buchon et al.   NATURE REVIEWS MICROBIOLOGY

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

big bang gene modulates gut immune tolerance in Drosophila

(2013) F. Bonnay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological and stem cell compartmentalization within the Drosophila midgut

(2013) Alexis Marianes et al.   eLife

Myosin light chain kinase: pulling the strings of epithelial tight junction function

(2012) Kevin E. Cunningham et al.   Annals of the New York Academy of Sciences

Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice

(2012) Wilma T Steegenga et al.   BMC Medical Genomics

Intestinal stem cell function in Drosophila and mice

(2012) Huaqi Jiang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Drosophilamidgut homeostasis involves neutral competition between symmetrically dividing intestinal stem cells

(2012) Joaquín de Navascués et al.   EMBO JOURNAL

Inducible progenitor-derived Wingless regulates adult midgut regeneration inDrosophila

(2012) Julia B Cordero et al.   EMBO JOURNAL

Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis

(2012) Manirath Khounlotham et al.   IMMUNITY

A novel protein complex, Mesh-Ssk, is required for septate junction formation in the Drosophila midgut

(2012) Y. Izumi et al.   JOURNAL OF CELL SCIENCE

Snakeskin, a membrane protein associated with smooth septate junctions, is required for intestinal barrier function in Drosophila

(2012) Y. Yanagihashi et al.   JOURNAL OF CELL SCIENCE

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

(2012) Ömer H. Yilmaz et al.   NATURE

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

(2011) Nicolas Buchon et al.   BMC BIOLOGY

Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth

(2011) Lucy Erin O'Brien et al.   CELL

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

EGF signaling regulates the proliferation of intestinal stem cells in Drosophila

(2011) B. Biteau et al.   DEVELOPMENT

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Manifestations and mechanisms of stem cell aging

(2011) Ling Liu et al.   JOURNAL OF CELL BIOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Controlled gene expression in primary Lgr5 organoid cultures

(2011) Bon-Kyoung Koo et al.   NATURE METHODS

The future of model organisms in human disease research

(2011) Timothy J. Aitman et al.   NATURE REVIEWS GENETICS

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

(2011) T. Kuraishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila

(2010) Huaqi Jiang et al.   Cell Stem Cell

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

Tissue Damage-Induced Intestinal Stem Cell Division in Drosophila

(2009) Alla Amcheslavsky et al.   Cell Stem Cell

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Diet and Aging

(2008) Matthew D.W. Piper et al.   Cell Metabolism

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

(2008) Benoît Biteau et al.   Cell Stem Cell

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

(2008) Guonan Lin et al.   NATURE