Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging

(2017) Christopher L. Koehler et al.   JOURNAL OF CELL BIOLOGY

Acute Dietary Restriction Acts via TOR, PP2A, and Myc Signaling to Boost Innate Immunity in Drosophila

(2017) Jung-Eun Lee et al.   Cell Reports

Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila

(2016) Subhash D. Katewa et al.   Cell Metabolism

Gastrointestinal stem cells in health and disease: from flies to humans

(2016) Hongjie Li et al.   Disease Models & Mechanisms

Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis

(2016) Martin Resnik-Docampo et al.   NATURE CELL BIOLOGY

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila

(2015) J. A. Bosch et al.   DEVELOPMENT

Cell Competition Modifies Adult Stem Cell and Tissue Population Dynamics in a JAK-STAT-Dependent Manner

(2015) Golnar Kolahgar et al.   DEVELOPMENTAL CELL

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

(2015) Rebecca I. Clark et al.   Cell Reports

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

(2014) Linlin Guo et al.   CELL

Escargotmaintains stemness and suppresses differentiation inDrosophilaintestinal stem cells

(2014) Jerome Korzelius et al.   EMBO JOURNAL

An ancient defense system eliminates unfit cells from developing tissues during cell competition

(2014) S. N. Meyer et al.   SCIENCE

The Digestive Tract ofDrosophila melanogaster

(2013) Bruno Lemaitre et al.   Annual Review of Genetics

Competitive Interactions Eliminate Unfit Embryonic Stem Cells at the Onset of Differentiation

(2013) Margarida Sancho et al.   DEVELOPMENTAL CELL

High carbohydrate–low protein consumption maximizes Drosophila lifespan

(2013) Kimberley D. Bruce et al.   EXPERIMENTAL GERONTOLOGY

Mechanisms of cell competition: Themes and variations

(2013) Romain Levayer et al.   JOURNAL OF CELL BIOLOGY

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Gut homeostasis in a microbial world: insights from Drosophila melanogaster

(2013) Nicolas Buchon et al.   NATURE REVIEWS MICROBIOLOGY

Myc-Dependent Genome Instability and Lifespan in Drosophila

(2013) Christina Greer et al.   PLoS One

Intestinal inflammation and stem cell homeostasis in aging Drosophila melanogaster

(2013) Arshad Ayyaz et al.   Frontiers in Cellular and Infection Microbiology

Intramyocellular Fatty-Acid Metabolism Plays a Critical Role in Mediating Responses to Dietary Restriction in Drosophila melanogaster

(2012) Subhash D. Katewa et al.   Cell Metabolism

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut

(2012) J. B. Cordero et al.   DEVELOPMENT

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog

(2011) Michael Rera et al.   Cell Metabolism

The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases

(2011) Richard H. Siggers et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases

(2011) J. Lin et al.   Disease Models & Mechanisms

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin-signaling pathway

(2011) N. H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary restriction and aging, 2009

(2010) Subhash D. Katewa et al.   AGING CELL

Some highlights of research on aging with invertebrates, 2010

(2010) Linda Partridge   AGING CELL

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Drosophila melanogaster as a model for human intestinal infection and pathology

(2010) Y. Apidianakis et al.   Disease Models & Mechanisms

Regulation of Drosophila lifespan by JNK signaling

(2010) Benoit Biteau et al.   EXPERIMENTAL GERONTOLOGY

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts

(2009) Marco Nooteboom et al.   AGING CELL

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

(2009) Huaqi Jiang et al.   CELL

Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila

(2009) N. Buchon et al.   GENES & DEVELOPMENT

Inflammatory bowel disease, gut bacteria and probiotic therapy

(2009) Caroline Reiff et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Aging and Survival: The Genetics of Life Span Extension by Dietary Restriction

(2008) William Mair et al.   Annual Review of Biochemistry

Nutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila

(2008) Aurelio A. Teleman et al.   Cell Metabolism

Simian Immunodeficiency Virus–Induced Intestinal Cell Apoptosis Is the Underlying Mechanism of the Regenerative Enteropathy of Early Infection

(2008) Qingsheng Li et al.   JOURNAL OF INFECTIOUS DISEASES

Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila

(2008) J.-H. Ryu et al.   SCIENCE