Article
Biochemistry & Molecular Biology
Qingyu Zhu, Fanchi Li, Qilong Shu, Yuanfei Wang, Piao Feng, Minli Dai, Tingting Mao, Haina Sun, Jing Wei, Bing Li
Summary: Studies have shown that exposure to low-concentration Chlorantraniliprole (CAP) impacts the disease resistance and gut microbial community structure of silkworms. Exposure to CAP disrupts the peritrophic matrix of silkworm larvae, leading to invasion of pathogenic bacteria in the hemolymph. CAP exposure also alters the expression of key genes in immune pathways and decreases the production of antimicrobial peptides, making silk-worms more susceptible to bacterial diseases.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Charles J. Mason, Kelli Hoover, Gary W. Felton
Summary: The study aimed to explore the impacts of plant genotypes, microbial sources, and host gut environment on bacterial community structure, revealing the contributions of microbial sources and plant genotypes to the diversity of gut bacterial communities in herbivorous insect larvae.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Margaret Steele, Erick V. S. Motta, Tejashwini Gattu, Daniel Martinez, Nancy A. Moran
Summary: Commensal microbes in animal guts play a role in excluding bacterial pathogens. In honey bees, disruption of the gut microbiota increases susceptibility to the opportunistic pathogen Serratia marcescens, which uses a T6SS to kill competitors in laboratory settings. However, within the bee gut, S. marcescens is rapidly eliminated in the presence of the microbiota and shows limited ability to compete with commensal species, indicating the importance of a healthy gut microbiota in protecting against pathogens.
MICROBIOLOGY SPECTRUM
(2021)
Article
Multidisciplinary Sciences
Ashutosh Pandey, Antonio Galeone, Seung Yeop Han, Benjamin A. Story, Gaia Consonni, William F. Mueller, Lars M. Steinmetz, Thomas Vaccari, Hamed Jafar-Nejad
Summary: Intestinal barrier dysfunction can cause inflammation and metabolic changes. However, the impact of gut bacteria versus non-bacterial insults on animal health in the context of barrier dysfunction is not well understood. This study establishes that loss of Drosophila N-glycanase 1 (Pngl) in a specific intestinal cell type leads to gut barrier defects, causing starvation and JNK overactivation. Loss of Pngl also results in immune and metabolic abnormalities, contributing to lethality.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Shousheng Ni, Yang Zhou, Lili Song, Yan Chen, Xia Wang, Xiaoyuan Du, Shicui Zhang
Summary: Ni et al. demonstrate that zebrafish RNA-binding protein ELAVL1a, abundantly stored in eggs and embryos, acts as a first-line innate immune player. They show that ELAVL1a recognizes bacterial molecular patterns to inhibit bacterial growth. This study suggests that ELAVL1a is a maternal immune factor protecting zebrafish embryos from bacterial infection.
COMMUNICATIONS BIOLOGY
(2021)
Review
Entomology
Shuai Bai, Zhichao Yao, Muhammad Fahim Raza, Zhaohui Cai, Hongyu Zhang
Summary: Insects maintain the homeostasis of their gut microbiome through various mechanisms such as physical defenses, the Duox-ROS system, the Imd signaling pathway, and intestinal symbiotic flora. These mechanisms help to efficiently remove harmful microorganisms and maintain a balanced microbial community.
Article
Microbiology
Haipeng Guo, Xuezhi Fu, Jikun He, Ruoyu Wang, Mengchen Yan, Jing Wang, Pengsheng Dong, Lei Huang, Demin Zhang
Summary: This study reveals the important role of gut bacterial community induced by a biofloc system (BFS) in protecting shrimp from bacterial pathogens. The study also provides a micro-ecological regulation strategy to improve aquatic animal diseases.
Letter
Respiratory System
Zaderer Viktoria, Dichtl Stefanie, Bellmann-Weiler Rosa, Lass-Floerl Cornelia, Posch Wilfried, Wilflingseder Doris
Summary: ColdZyme(R) mouth spray effectively blocks respiratory tissue infection and protects epithelial integrity. In vitro data from this study suggest that ColdZyme(R) mouth spray may have an impact on protecting against SARS-CoV-2 transmission.
RESPIRATORY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Swathi Penumutchu, Benjamin J. Korry, Katharine Hewlett, Peter Belenky
Summary: This study explores dietary fiber supplements as potential modulators to reduce gut dysbiosis caused by antibiotics. The results suggest that fiber prebiotics significantly reduce the impact of antibiotic treatment on the microbiome composition and function, leading to a decrease in the abundance of anaerobic bacteria and metabolic pathways associated with oxidative metabolism.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hwaseok Hong, Uk-Jae Lee, Seul Hoo Lee, Hyun Kim, Gyu-Min Lim, Sang-Hyuk Lee, Hyeoncheol Francis Son, Byung-Gee Kim, Kyung-Jin Kim
Summary: This study reports a tyrosinase called SaTYR from Streptomyces avermitilis that has higher activity against tyrosine residues on the protein surface compared to other tyrosinases. The crystal structure of SaTYR was determined, revealing a relatively flat and shallow substrate-binding pocket. The study also provides a structural rationale for determining the optimal positions for introducing target tyrosine residues in SaTYR-mediated protein modification.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Microbiology
Delaney L. Miller, Eric A. Smith, Irene L. G. Newton
Summary: The study found that the honey bee-associated bacterium Bombella apis can inhibit the growth of insect fungal pathogens, effectively protecting bee broods from infection in vivo, possibly through the secretion of antifungal metabolites. This research provides clues for the development of new antifungal treatments.
Article
Biology
Astrid Hoermann, Sofia Tapanelli, Paolo Capriotti, Giuseppe Del Corsano, Ellen Kg Masters, Tibebu Habtewold, George K. Christophides, Nikolai Windbichler
Summary: Gene drives for mosquito population replacement show promise for malaria control, but face challenges in testing and regulatory hurdles. By making minimal genetic modifications to mosquito genes, they can be converted into non-autonomous gene drives that interfere with the development of Plasmodium falciparum. This approach, utilizing native regulatory sequences for targeted delivery of antimalarial molecules, has potential for acceptable testing pathways for malaria eradication.
Article
Microbiology
Kazuyuki Kasahara, Robert L. Kerby, Qijun Zhang, Meenakshi Pradhan, Margarete Mehrabian, Aldons J. Lusis, Goran Bergstrom, Fredrik Backhed, Federico E. Rey
Summary: The study suggests that gut microbiota plays a role in the progression of inflammatory diseases such as atherosclerosis. It shows that certain gut bacteria can use uric acid as a carbon and energy source, and their catabolism of purines influences the levels of uric acid in the body. This highlights the importance of gut microbes in maintaining purine homeostasis and overall health.
CELL HOST & MICROBE
(2023)
Article
Multidisciplinary Sciences
Jiarong Zhou, Nishta Krishnan, Zhongyuan Guo, Christian J. Ventura, Maya Holay, Qiangzhe Zhang, Xiaoli Wei, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: This study investigates the effectiveness of a biomimetic nanotoxoid vaccine in protecting immunodeficient animals from Pseudomonas aeruginosa infection. The nanotoxoids utilize a macrophage membrane coating to sequester and present bacterial virulence factors, providing rapid and long-lasting immunity. The nanovaccine can be administered through multiple routes and effectively protects against lethal infections in pneumonia and septicemia models.
Article
Developmental Biology
Kentaro Yoshida, Shigeo Hayashi
Summary: Dying cells in the epithelia communicate with neighboring cells to initiate coordinated cell removal to maintain epithelial integrity. Epidermal growth factor (EGF) receptor (EGFR) signaling plays an important role in the maintenance of epithelial homeostasis. In Drosophila embryos, the enhanced extracellular signal-regulated kinase (ERK) signaling in epithelial tissues undergoing groove formation. EGFR mutant embryos show sporadic apical cell extrusion in the head, leading to a cascade of apical extrusions throughout the ventral body wall. This process is apoptosis dependent and can cause massive tissue disintegration in EGFR mutant epithelia. Tissue detachment from the vitelline membrane triggers the EGFR mutant phenotype. Therefore, EGFR not only promotes cell survival but also maintains epithelial integrity.
Article
Microbiology
Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
CELL HOST & MICROBE
(2018)
Article
Biochemistry & Molecular Biology
Toshio Shibata, Yuki Kobayashi, Yuto Ikeda, Shun-ichiro Kawabata
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Virology
Miyu Moriyama, Manabu Igarashi, Takumi Koshiba, Takashi Irie, Ayato Takada, Takeshi Ichinohe
JOURNAL OF VIROLOGY
(2018)
Article
Multidisciplinary Sciences
Takuma Yoshizumi, Hiromi Imamura, Tomohiro Taku, Takahiro Kuroki, Atsushi Kawaguchi, Kaori Ishikawa, Kazuto Nakada, Takumi Koshiba
SCIENTIFIC REPORTS
(2017)
Review
Biochemistry & Molecular Biology
Takumi Koshiba, Hidetaka Kosako
JOURNAL OF BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Kai Yasukawa, Daisuke Kinoshita, Keisuke Yaku, Takashi Nakagawa, Takumi Koshiba
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Miyu Moriyama, Takumi Koshiba, Takeshi Ichinohe
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Keisuke Yamashita, Toshio Shibata, Toshiaki Takahashi, Yuki Kobayashi, Shun-ichiro Kawabata
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Miyu Moriyama, Minami Nagai, Yuhei Maruzuru, Takumi Koshiba, Yasushi Kawaguchi, Takeshi Ichinohe
Article
Multidisciplinary Sciences
Johannes Burtscher, Giuseppe Cappellano, Akiko Omori, Takumi Koshiba, Gregoire P. Millet
Review
Biochemistry & Molecular Biology
Kai Yasukawa, Takumi Koshiba
Summary: Mitochondria are multi-functioning organelles involved in a wide range of biological processes and innate immune responses against microorganisms or irritants. Activation of two signaling pathways, NLR family pyrin domain-containing 3 inflammasomes and retinoic acid-inducible gene I-like receptor pathway, is crucial for mitochondrial-mediated innate immunity. Targeting mitochondrial functions could be a potential therapeutic approach for managing infectious diseases and autoinflammatory disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Yamashita, Naoki Takeshita, Aina Arita, Toshio Shibata, Yuki Kobayashi, Shun-ichiro Kawabata
Summary: This study elucidates the impact of a mutant, proB-murasame, in the LPS-triggered coagulation cascade of horseshoe crabs, which showed an 8-fold increase in activation of proCE by regeneration of the His-loop disulphide. This mutant may serve as a high value-adding reagent for LPS detection in biological systems.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Yamashita, Daisuke Takahashi, Yuki Yamamoto, Shingo Kiyomoto, Toshio Shibata, Shun-ichiro Kawabata
Summary: Through experiments, it was found that calcium ions can increase the production of clotting enzymes. The coagulation cascade, consisting of three protease zymogens with different functions, can be divided into three stages, and calcium ions only enhance protein activation in the second stage. At the same time, it was confirmed that lipopolysaccharide can interact with calcium ions to facilitate the occurrence of the cascade reaction.
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yuki Hanada, Naotada Ishihara, Lixiang Wang, Hidenori Otera, Takaya Ishihara, Takumi Koshiba, Katsuyoshi Mihara, Yoshihiro Ogawa, Masatoshi Nomura
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Takahiro Yoshinaka, Hidetaka Kosako, Takuma Yoshizumi, Ryo Furukawa, Yu Hirano, Osamu Kuge, Taro Tamada, Takumi Koshiba