PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Metabolic Control of Longevity

(2016) Carlos López-Otín et al.   CELL

Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan

(2016) Hongjie Li et al.   Cell Host & Microbe

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

(2016) Martin D. Brand et al.   Cell Metabolism

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

dFOXO Activates Large and Small Heat Shock Protein Genes in Response to Oxidative Stress to Maintain Proteostasis inDrosophila

(2016) Marissa R. Donovan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans

(2015) Yaguang Ren et al.   EXPERIMENTAL GERONTOLOGY

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Sensing of Amino Acids in a Dopaminergic Circuitry Promotes Rejection of an Incomplete Diet in Drosophila

(2014) Marianne Bjordal et al.   CELL

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Mitochondrial Proteostasis in the Control of Aging and Longevity

(2014) Martin Borch Jensen et al.   Cell Metabolism

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

(2014) Wei Lu et al.   Nature Communications

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster

(2014) Nazif Alic et al.   PLoS Genetics

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening

(2013) Adam L. Orr et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Misregulation of an Adaptive Metabolic Response Contributes to the Age-Related Disruption of Lipid Homeostasis in Drosophila

(2013) Jason Karpac et al.   Cell Reports

Activin Signaling Targeted by Insulin/dFOXO Regulates Aging and Muscle Proteostasis in Drosophila

(2013) Hua Bai et al.   PLoS Genetics

Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction

(2013) Kavitha Kannan et al.   Frontiers in Physiology

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

(2012) I Pimenta de Castro et al.   CELL DEATH AND DIFFERENTIATION

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5

(2012) Shiori Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator

(2012) Min Zhuang et al.   MOLECULAR CELL

Prevention of Apoptosis by Mitochondrial Phosphatase PGAM5 in the Mushroom Body Is Crucial for Heat Shock Resistance in Drosophila melanogaster

(2012) Yosuke Ishida et al.   PLoS One

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

A Hormone-Dependent Module Regulating Energy Balance

(2011) Biao Wang et al.   CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Dynamic Coordination of Innate Immune Signaling and Insulin Signaling Regulates Systemic Responses to Localized DNA Damage

(2011) Jason Karpac et al.   DEVELOPMENTAL CELL

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

(2011) L. Palanker Musselman et al.   Disease Models & Mechanisms

The Drosophila FoxA Ortholog Fork Head Regulates Growth and Gene Expression Downstream of Target of Rapamycin

(2011) Margret H. Bülow et al.   PLoS One

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

FOXO-dependent regulation of innate immune homeostasis

(2010) Thomas Becker et al.   NATURE

The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila

(2010) Yuzuru Imai et al.   PLoS Genetics

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

(2010) Benoît Biteau et al.   PLoS Genetics

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

(2009) K. Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration, and apoptosis in Drosophila

(2008) Pin-Chao Liao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

(2008) Shih-Ching Lo et al.   EXPERIMENTAL CELL RESEARCH

FOXO3A Regulates Peroxiredoxin III Expression in Human Cardiac Fibroblasts

(2008) Calin B. Chiribau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain IGF-1 Receptors Control Mammalian Growth and Lifespan through a Neuroendocrine Mechanism

(2008) Laurent Kappeler et al.   PLOS BIOLOGY

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL