4E-BP is a target of the GCN2–ATF4 pathway duringDrosophiladevelopment and aging

PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress

(2015) Lifen Wang et al.   PLoS Genetics

A Drosophila Reporter for the Translational Activation of ATF4 Marks Stressed Cells during Development

(2015) Kwonyoon Kang et al.   PLoS One

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Sensing of Amino Acids in a Dopaminergic Circuitry Promotes Rejection of an Incomplete Diet in Drosophila

(2014) Marianne Bjordal et al.   CELL

Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila

(2014) A. R. Armstrong et al.   DEVELOPMENT

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

(2014) Thomas D. Baird et al.   MOLECULAR BIOLOGY OF THE CELL

The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation inCaenorhabditis elegans

(2013) Aris Rousakis et al.   AGING CELL

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

(2013) W. Zhang et al.   GENES & DEVELOPMENT

Coordinate regulation of eIF2  phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

(2013) E. Malzer et al.   JOURNAL OF CELL SCIENCE

Examination of a second node of translational control in the unfolded protein response

(2013) A. M. Preston et al.   JOURNAL OF CELL SCIENCE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The insulin receptor cellular IRES confers resistance to eIF4A inhibition

(2013) Calla M Olson et al.   eLife

Infection-Induced Host Translational Blockage Inhibits Immune Responses and Epithelial Renewal in the Drosophila Gut

(2012) Sveta Chakrabarti et al.   Cell Host & Microbe

FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption

(2012) Inna V. Nechipurenko et al.   JOURNAL OF CELL BIOLOGY

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model

(2012) Min-Ji Kang et al.   NATURE CELL BIOLOGY

dFOXO-independent effects of reduced insulin-like signaling inDrosophila

(2011) Cathy Slack et al.   AGING CELL

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

(2010) Linda Partridge et al.   EXPERIMENTAL GERONTOLOGY

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

(2010) E. Malzer et al.   JOURNAL OF CELL SCIENCE

d4eBPacts downstream of both dTOR and dFoxo to modulate cardiac functional aging inDrosophila

(2009) Robert Wessells et al.   AGING CELL

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

(2008) Maria E. Giannakou et al.   AGING CELL

Drosophila lifespan control by dietary restriction independent of insulin-like signaling

(2008) Kyung-Jin Min et al.   AGING CELL

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

ATF4-Mediated Induction of 4E-BP1 Contributes to Pancreatic β Cell Survival under Endoplasmic Reticulum Stress

(2008) Suguru Yamaguchi et al.   Cell Metabolism