Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

(2019) Yasmine J. Liu et al.   PLoS Genetics

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

(2019) Alexander Tyshkovskiy et al.   Cell Metabolism

Dietary methionine influences therapy in mouse cancer models and alters human metabolism

(2019) Xia Gao et al.   NATURE

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H 2 S Production

(2018) Alban Longchamp et al.   CELL

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Nutritional Control of Stem Cell Division through S-Adenosylmethionine in Drosophila Intestine

(2018) Fumiaki Obata et al.   DEVELOPMENTAL CELL

The Components of Age-Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats

(2018) Desiree Wanders et al.   Obesity

Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression

(2018) Liangping Su et al.   Cell Reports

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

(2018) Oswaldo A. Lozoya et al.   PLOS BIOLOGY

Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

(2018) Zaijun Ma et al.   eLife

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

(2018) Clea Bárcena et al.   Cell Reports

Nicotinamide-N-methyltransferase controls behavior, neurodegeneration and lifespan by regulating neuronal autophagy

(2018) Kathrin Schmeisser et al.   PLoS Genetics

Homocysteine and age-associated disorders

(2018) E.A. Ostrakhovitch et al.   AGEING RESEARCH REVIEWS

Methionine restriction leads to hyperhomocysteinemia and alters hepatic H2S production capacity in Fischer-344 rats

(2018) Nahid Tamanna et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells

(2018) Cristina Cruz et al.   eLife

Short term methionine restriction increases hepatic global DNA methylation in adult but not young male C57BL/6J mice

(2017) Dwight A.L. Mattocks et al.   EXPERIMENTAL GERONTOLOGY

The amino acid metabolite homocysteine activates mTORC1 to inhibit autophagy and form abnormal proteins in human neurons and mice

(2017) Khoosheh Khayati et al.   FASEB JOURNAL

Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

(2017) Thomas Wilhelm et al.   GENES & DEVELOPMENT

A Metabolic Function for Phospholipid and Histone Methylation

(2017) Cunqi Ye et al.   MOLECULAR CELL

Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype

(2017) Laura A. Forney et al.   Obesity

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

Using artificial diets to understand the nutritional physiology of Drosophila melanogaster

(2017) Matthew DW Piper   Current Opinion in Insect Science

Methionine restriction on lipid metabolism and its possible mechanisms

(2016) Xihong Zhou et al.   AMINO ACIDS

From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span

(2016) R. Scott McIsaac et al.   Annals of the New York Academy of Sciences

Methionine restriction beyond life-span extension

(2016) Gene P. Ables et al.   Annals of the New York Academy of Sciences

RadicalS-Adenosylmethionine Enzymes in Human Health and Disease

(2016) Bradley J. Landgraf et al.   Annual Review of Biochemistry

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span inDrosophila

(2016) Andrey A. Parkhitko et al.   GENES & DEVELOPMENT

Functions of Polyamines in Mammals

(2016) Anthony E. Pegg   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptional Corepressor SIN3 Directly Regulates Genes Involved in Methionine Catabolism and Affects Histone Methylation, Linking Epigenetics and Metabolism

(2016) Mengying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Tissue nonautonomous effects of fat body methionine metabolism on imaginal disc repair inDrosophila

(2016) Soshiro Kashio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

StimulatingS-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK

(2016) Takafumi Ogawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyamines in aging and disease

(2016) Nadège Minois et al.   Aging-US

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

(2016) Nan Jiang et al.   Aging-US

Methionine restriction and life-span control

(2015) Byung Cheon Lee et al.   Annals of the New York Academy of Sciences

Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits

(2015) Christopher Hine et al.   CELL

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

s-Adenosylmethionine Levels Govern Innate Immunity through Distinct Methylation-Dependent Pathways

(2015) Wei Ding et al.   Cell Metabolism

Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity

(2015) Siming Ma et al.   Cell Metabolism

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

(2015) Eric Lieberman Greer et al.   CELL RESEARCH

Lifespan extension and increased resistance to environmental stressors by N-Acetyl-L-Cysteine in Caenorhabditis elegans

(2015) SI Oh et al.   Clinics

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span

(2015) Mintie Pu et al.   GENES & DEVELOPMENT

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

(2015) Payel Sen et al.   GENES & DEVELOPMENT

NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging

(2015) Lindsay A. Bonsignore et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

(2015) John L. Wallace et al.   NATURE REVIEWS DRUG DISCOVERY

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan

(2015) Markus Schosserer et al.   Nature Communications

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan

(2015) Fumiaki Obata et al.   Nature Communications

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

(2015) Jichun Zhou et al.   Nature Communications

Dietary Methionine Restriction in Mice Elicits an Adaptive Cardiovascular Response to Hyperhomocysteinemia

(2015) Gene P. Ables et al.   Scientific Reports

Disruption of Methionine Metabolism in Drosophila melanogaster Impacts Histone Methylation and Results in Loss of Viability

(2015) Mengying Liu et al.   G3-Genes Genomes Genetics

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

(2014) Emma K. Lees et al.   AGING CELL

Methionine restriction slows down senescence in human diploid fibroblasts

(2014) Rafał Kozieł et al.   AGING CELL

Quantitation of Cellular Metabolic Fluxes of Methionine

(2014) Tomer Shlomi et al.   ANALYTICAL CHEMISTRY

Sulfur as a Signaling Nutrient Through Hydrogen Sulfide

(2014) Omer Kabil et al.   Annual Review of Nutrition

Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells

(2014) Hong-Yeoul Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kinase mTOR: Regulation and role in maintenance of cellular homeostasis, tumor development, and aging

(2014) A. A. Parkhitko et al.   BIOCHEMISTRY-MOSCOW

Impact of age-associated increase in 2'-O-methylation of miRNAs on aging and neurodegeneration in Drosophila

(2014) M. Abe et al.   GENES & DEVELOPMENT

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Nutrient control of Drosophila longevity

(2014) Marc Tatar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification

(2014) Christoph Ruckenstuhl et al.   PLoS Genetics

H3K4 demethylase activities repress proliferative and postmitotic aging

(2013) Stacy M. Alvares et al.   AGING CELL

Autophagy: Mechanisms, regulation, and its role in tumorigenesis

(2013) A. A. Parkhitko et al.   BIOCHEMISTRY-MOSCOW

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation

(2013) Sunil Laxman et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction

(2013) Ines Sanchez-Roman et al.   EXPERIMENTAL GERONTOLOGY

Expression of DNA Methyltransferases Is Influenced by Growth Hormone in the Long-Living Ames Dwarf Mouse In Vivo and In Vitro

(2013) V. L. Armstrong et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

Independent and Additive Effects of Glutamic Acid and Methionine on Yeast Longevity

(2013) Ziyun Wu et al.   PLoS One

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

(2013) Baohua Liu et al.   Nature Communications

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

(2012) Paul Cavuoto et al.   CANCER TREATMENT REVIEWS

Replicative and Chronological Aging in Saccharomyces cerevisiae

(2012) Valter D. Longo et al.   Cell Metabolism

Value of 11C-methionine PET in imaging brain tumours and metastases

(2012) Andor W. J. M. Glaudemans et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Genomic and Metabolic Responses to Methionine-Restricted and Methionine-Restricted, Cysteine-Supplemented Diets in Fischer 344 Rat Inguinal Adipose Tissue, Liver and Quadriceps Muscle

(2012) Carmen E. Perrone et al.   Journal of Nutrigenetics and Nutrigenomics

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Methionine-Restricted C57BL/6J Mice Are Resistant to Diet-Induced Obesity and Insulin Resistance but Have Low Bone Density

(2012) Gene P. Ables et al.   PLoS One

Heterochromatin Formation Promotes Longevity and Represses Ribosomal RNA Synthesis

(2012) Kimberly Larson et al.   PLoS Genetics

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans

(2011) Zhuoyu Ni et al.   AGING CELL

Hypermethioninemias of genetic and non-genetic origin: A review

(2011) S. Harvey Mudd   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Asymmetric Arginine Dimethylation Determines Life Span in C. elegans by Regulating Forkhead Transcription Factor DAF-16

(2011) Yuta Takahashi et al.   Cell Metabolism

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Targeting methionine auxotrophy in cancer: discovery & exploration

(2011) Vaidehi Agrawal et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Dietary Methionine Restriction Increases Fat Oxidation in Obese Adults with Metabolic Syndrome

(2011) Eric P. Plaisance et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Increased transsulfuration mediates longevity and dietary restriction in Drosophila

(2011) H. Kabil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatin remodeling in the aging genome of Drosophila

(2010) Jason G. Wood et al.   AGING CELL

Identification of evolutionarily conserved genetic regulators of cellular aging

(2010) Gerhard T. Laschober et al.   AGING CELL

drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans

(2010) Tsui-Ting Ching et al.   AGING CELL

13C metabolic flux analysis in complex systems

(2010) Nicola Zamboni   CURRENT OPINION IN BIOTECHNOLOGY

Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice

(2010) K. Flurkey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Uncovering the Human Methyltransferasome

(2010) Tanya C. Petrossian et al.   MOLECULAR & CELLULAR PROTEOMICS

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia

(2010) Amany K. Elshorbagy et al.   NUTRITION

Essential Functions of the Histone Demethylase Lid

(2010) Ling Li et al.   PLoS Genetics

Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation

(2010) Paola Fabrizio et al.   PLoS Genetics

Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death

(2009) Ranjana Poddar et al.   JOURNAL OF NEUROCHEMISTRY

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance

(2009) A. P. Siebold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinformatic identification of novel methyltransferases

(2009) Tanya Petrossian et al.   Epigenomics

Purification, crystallization and preliminary crystallographic studies of plantS-adenosyl-L-homocysteine hydrolase (Lupinus luteus)

(2008) Krzysztof Brzezinski et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The IRBIT domain adds new functions to the AHCY family

(2008) Benoit Devogelaere et al.   BIOESSAYS

Methionine in proteins defends against oxidative stress

(2008) Shen Luo et al.   FASEB JOURNAL

Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1

(2008) J. Franke et al.   JOURNAL OF CELL SCIENCE

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

(2008) Mark F. McCarty et al.   MEDICAL HYPOTHESES