S-adenosylmethionine in Liver Health, Injury, and Cancer

S-adenosyl-L-methionine Treatment for Alcoholic Liver Disease: A Double-Blinded, Randomized, Placebo-Controlled Trial

(2011) Valentina Medici et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Sensing of energy and nutrients by AMP-activated protein kinase

(2011) D Grahame Hardie   AMERICAN JOURNAL OF CLINICAL NUTRITION

High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

(2011) John E Eaton et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Down-Regulation of Methylthioadenosine Phosphorylase ( MTAP ) Induces Progression of Hepatocellular Carcinoma via Accumulation of 5′-Deoxy-5′-Methylthioadenosine (MTA)

(2011) Georgi Kirovski et al.   AMERICAN JOURNAL OF PATHOLOGY

PneumocystisS-Adenosylmethionine Transport

(2011) Oscar Perez-Leal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Regulation of polyamine metabolism by translational control

(2011) Oscar Perez-Leal et al.   AMINO ACIDS

Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity

(2011) Joseph R. Bertino et al.   CANCER BIOLOGY & THERAPY

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

(2011) Amy K. Walker et al.   CELL

Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine

(2011) Satish C. Kalhan et al.   CLINICAL SCIENCE

Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis

(2011) Srinivasan Dasarathy et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Role of AMP-activated protein kinase in the control of hepatocyte priming and proliferation during liver regeneration

(2011) Marta Varela-Rey et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice

(2011) Ainara Cano et al.   HEPATOLOGY

Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans

(2011) Yingxiu Li et al.   JOURNAL OF BIOCHEMISTRY

Deletion of Betaine-HomocysteineS-Methyltransferase in Mice Perturbs Choline and 1-Carbon Metabolism, Resulting in Fatty Liver and Hepatocellular Carcinomas

(2011) Ya-Wen Teng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation

(2011) Maria Lauda Tomasi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia Induces Genomic DNA Demethylation through the Activation of HIF-1  and Transcriptional Upregulation of MAT2A in Hepatoma Cells

(2011) Q. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Methionine Adenosyltransferase II Serves as a Transcriptional Corepressor of Maf Oncoprotein

(2011) Yasutake Katoh et al.   MOLECULAR CELL

Molecular carcinogenesis of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: one step closer to personalized medicine?

(2011) Mia Kumar et al.   Cell and Bioscience

Role of Methionine Adenosyltransferase Genes in Hepatocarcinogenesis

(2011) Komal Ramani et al.   Cancers

Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice

(2010) Jiaping Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Analysis of the liver mitochondrial proteome in response to ethanol and S-adenosylmethionine treatments: novel molecular targets of disease and hepatoprotection

(2010) Kelly K. Andringa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

S-Adenosyl Methionine (SAMe) Augmentation of Serotonin Reuptake Inhibitors for Antidepressant Nonresponders With Major Depressive Disorder: A Double-Blind, Randomized Clinical Trial

(2010) George I. Papakostas et al.   AMERICAN JOURNAL OF PSYCHIATRY

S-Adenosyl Methionine (SAMe) Augmentation in Major Depressive Disorder

(2010) J. Craig Nelson   AMERICAN JOURNAL OF PSYCHIATRY

Distribution of methionine between cells and incubation medium in suspension of rat hepatocytes

(2010) Tatyana K. Korendyaseva et al.   AMINO ACIDS

Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines

(2010) Sheng-Ming Wu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice

(2010) M.L. Martinez-Chantar et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The antiviral protein viperin is a radical SAM enzyme

(2010) Kaitlin S. Duschene et al.   FEBS LETTERS

HuR/Methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis

(2010) Mercedes Vázquez–Chantada et al.   GASTROENTEROLOGY

S-Adenosyl Methionine Improves Early Viral Responses and Interferon-Stimulated Gene Induction in Hepatitis C Nonresponders

(2010) Jordan J. Feld et al.   GASTROENTEROLOGY

Activation of LKB1-Akt pathway independent of phosphoinositide 3-kinase plays a critical role in the proliferation of hepatocellular carcinoma from nonalcoholic steatohepatitis

(2010) Nuria Martínez-López et al.   HEPATOLOGY

S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes

(2010) Maria Lauda Tomasi et al.   HEPATOLOGY

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

(2010) Marta Varela-Rey et al.   HEPATOLOGY

Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice

(2010) Kwang Suk Ko et al.   HEPATOLOGY

Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis

(2010) Francisco Caballero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth and Metastases of Human Lung Cancer Are Inhibited in Mouse Xenografts by a Transition State Analogue of 5′-Methylthioadenosine Phosphorylase

(2010) Indranil Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Function and Intracellular Localization of Methionine Adenosyltransferase 2β Splicing Variants

(2010) Meng Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High AffinityS-Adenosylmethionine Plasma Membrane Transporter ofLeishmaniaIs a Member of the Folate Biopterin Transporter (FBT) Family

(2010) Larbi Dridi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cystathionine γ-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury

(2010) Isao Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homocysteine Methyltransferases Mht1 and Sam4 Prevent the Accumulation of Age-damaged (R,S)-AdoMet in the YeastSaccharomyces cerevisiae

(2010) Chris R. Vinci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes

(2010) Randall Grubbs et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Hydrogen sulfide as a gasotransmitter

(2010) Moataz M. Gadalla et al.   JOURNAL OF NEUROCHEMISTRY

Liquid Chromatography−Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease

(2010) Jonathan Barr et al.   JOURNAL OF PROTEOME RESEARCH

Uncovering the Human Methyltransferasome

(2010) Tanya C. Petrossian et al.   MOLECULAR & CELLULAR PROTEOMICS

S-Adenosyl-Methionine and Betaine Improve Early Virological Response in Chronic Hepatitis C Patients with Previous Nonresponse

(2010) Magdalena Filipowicz et al.   PLoS One

Yeast, Plants, Worms, and Flies Use a Methyltransferase to Metabolize Age-Damaged (R,S)-AdoMet, but What Do Mammals Do?

(2010) Chris R. Vinci et al.   REJUVENATION RESEARCH

Hepatoprotective effects ofS-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

(2010) Arthur I Cederbaum   WORLD JOURNAL OF GASTROENTEROLOGY

Impaired methylation as a novel mechanism for proteasome suppression in liver cells

(2009) Natalia A. Osna et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The logic of the hepatic methionine metabolic cycle

(2009) M.V. Martinov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma

(2009) Y. Kadariya et al.   CANCER RESEARCH

TNF -dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase

(2009) R. P. Matthews et al.   DEVELOPMENT

Conformational signals in the C-terminal domain of methionine adenosyltransferase I/III determine its nucleocytoplasmic distribution

(2009) Edel Reytor et al.   FASEB JOURNAL

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model

(2009) Shelly C. Lu et al.   HEPATOLOGY

Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice

(2009) Heping Yang et al.   HEPATOLOGY

Dysregulation of glutathione synthesis during cholestasis in mice: Molecular mechanisms and therapeutic implications

(2009) Heping Yang et al.   HEPATOLOGY

Impaired liver regeneration in mice lacking glycine N-methyltransferase

(2009) Marta Varela-Rey et al.   HEPATOLOGY

S-adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome

(2009) Oliver Vugrek et al.   HUMAN MUTATION

GlycineN-Methyltransferase and Regulation ofS-Adenosylmethionine Levels

(2009) Zigmund Luka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells

(2009) T. W. H. Li et al.   MOLECULAR PHARMACOLOGY

Liver Repopulation and Carcinogenesis: Two Sides of the Same Coin?

(2008) Fabio Marongiu et al.   AMERICAN JOURNAL OF PATHOLOGY

Spermidine/spermine-N1-acetyltransferase: a key metabolic regulator

(2008) Anthony E. Pegg   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Methionine Metabolism and Liver Disease

(2008) José M. Mato et al.   Annual Review of Nutrition

Prohibitin function within mitochondria: Essential roles for cell proliferation and cristae morphogenesis

(2008) Carsten Merkwirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells

(2008) Tanvi S Jani et al.   CELL RESEARCH

Structure-function relationships in methionine adenosyltransferases

(2008) G. D. Markham et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Treatment of Primary Biliary Cirrhosis: Therapy with Choleretic and Immunosuppressive Agents

(2008) Marina G. Silveira et al.   Clinics in Liver Disease

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Human prohibitin 1 maintains the organization and stability of the mitochondrial nucleoids

(2008) Katsumi Kasashima et al.   EXPERIMENTAL CELL RESEARCH

S-Adenosylmethionine Regulates Apurinic/Apyrimidinic Endonuclease 1 Stability: Implication in Hepatocarcinogenesis

(2008) Maria Lauda Tomasi et al.   GASTROENTEROLOGY

CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis

(2008) Wei Ding et al.   HEPATOLOGY

S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

(2008) Ainhoa Iglesias Ara et al.   HEPATOLOGY

Evidence for LKB1/AMP-activated protein kinase/ endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation

(2008) Mercedes Vázquez-Chantada et al.   HEPATOLOGY

Involvement of CCAAT/enhancer binding protein-ß (C/EBPß) in epigenetic regulation of mouse methionine adenosyltransferase 1A gene expression

(2008) Reiko Ikeda et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility

(2008) Yi-Jen Liao et al.   INTERNATIONAL JOURNAL OF CANCER

S-Adenosylmethionine in cell growth, apoptosis and liver cancer

(2008) Shelly C Lu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice

(2008) Kwangsuk Ko et al.   LABORATORY INVESTIGATION

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Interferon signaling and treatment outcome in chronic hepatitis C

(2008) M. Sarasin-Filipowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-adenosylmethionine Inhibits Ubiquitin-Proteasome System In Vitro and on Rat Vascular Smooth Muscle Cells

(2008) Fabrizio D'Anselmi et al.   PROTEIN AND PEPTIDE LETTERS

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine  -Lyase

(2008) G. Yang et al.   SCIENCE

Expression Pattern, Regulation, and Functions of Methionine Adenosyltransferase 2β Splicing Variants in Hepatoma Cells

(2007) Heping Yang et al.   GASTROENTEROLOGY

Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression

(2007) Prachi T. Hote et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY