Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
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Title
Role of PI3K/AKT pathway in cancer: the framework of malignant behavior
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Journal
MOLECULAR BIOLOGY REPORTS
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-04-25
DOI
10.1007/s11033-020-05435-1
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- TDRG1 regulates chemosensitivity of seminoma TCam-2 cells to cisplatin via PI3K/Akt/mTOR signaling pathway and mitochondria-mediated apoptotic pathway
- (2016) Yu Gan et al. CANCER BIOLOGY & THERAPY
- miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells
- (2016) Simon Raffel et al. CANCER CELL
- PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P
- (2016) Bin Huang et al. CANCER LETTERS
- Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non–Small Cell Lung Cancer Cell Lines and Tumor Models
- (2016) David Y.A. Dadey et al. CLINICAL CANCER RESEARCH
- Combination of Imatinib Mesylate and AKT Inhibitor Provides Synergistic Effects in Preclinical Study of Gastrointestinal Stromal Tumor
- (2016) Phillip Zook et al. CLINICAL CANCER RESEARCH
- Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer
- (2016) William J. Gibson et al. CLINICAL CANCER RESEARCH
- Genetic and Methylation-Induced Loss of miR-181a2/181b2 within chr9q33.3 Facilitates Tumor Growth of Cervical Cancer through the PIK3R3/Akt/FoxO Signaling Pathway
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- FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
- (2016) Aldwin Suryo Rahmanto et al. EMBO JOURNAL
- Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities
- (2016) Barbara Bournet et al. EUROPEAN JOURNAL OF CANCER
- Asparaginyl endopeptidase promotes proliferation and invasiveness of prostate cancer cells via PI3K/AKT signaling pathway
- (2016) Wenjing Zhu et al. GENE
- MicroRNA-214 acts as a potential oncogene in breast cancer by targeting the PTEN-PI3K/Akt signaling pathway
- (2016) FANG WANG et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models
- (2016) NICOLE M. JONES et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways
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- Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
- (2016) Iñigo Landa et al. JOURNAL OF CLINICAL INVESTIGATION
- PI3K p110β isoform synergizes with JNK in the regulation of glioblastoma cell proliferation and migration through Akt and FAK inhibition
- (2016) Hua-Fu Zhao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway
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- The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR
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- The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression
- (2016) Anna Joy et al. JOURNAL OF NEURO-ONCOLOGY
- Suppression of SPIN1-mediated PI3K-Akt pathway by miR-489 increases chemosensitivity in breast cancer
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- The novel PI3K-δ inhibitor TGR-1202 enhances Brentuximab Vedotin-induced Hodgkin lymphoma cell death via mitotic arrest
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- Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis
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- NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
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- PRL-3 promotes the peritoneal metastasis of gastric cancer through the PI3K/Akt signaling pathway by regulating PTEN
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- Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma
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- Tumor-Suppressor Gene NBPF1 Inhibits Invasion and PI3K/mTOR Signaling in Cervical Cancer Cells
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- AKT signaling in ERBB2-amplified breast cancer
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- Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα
- (2016) Vincenzo N. Talesa et al. PROSTATE
- The PI3K pathway: clinical inhibition in chronic lymphocytic leukemia
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- PI3K signaling pathway in normal B cells and indolent B-cell malignancies
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- Hematopoietic Stem Cell Activity Is Regulated by Pten Phosphorylation Through a Niche-Dependent Mechanism
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- EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway
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- miR-196b regulates gastric cancer cell proliferation and invasion via PI3K/AKT/mTOR signaling pathway
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- IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation
- (2016) Gerjon J. Ikink et al. Nature Communications
- miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
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- MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling
- (2016) Anne Offermann et al. Oncotarget
- ST6Gal-I overexpression facilitates prostate cancer progression via the PI3K/Akt/GSK-3β/β-catenin signaling pathway
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- JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer
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- miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer
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- miRNA-150 downregulation promotes pertuzumab resistance in ovarian cancer cells via AKT activation
- (2015) Delinaer Wuerkenbieke et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- RLIP76-dependent suppression of PI3K/AKT/Bcl-2 pathway by miR-101 induces apoptosis in prostate cancer
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- HPIP promotes thyroid cancer cell growth, migration and EMT through activating PI3K/AKT signaling pathway
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- Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML
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- Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
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- Targeting PI3K/AKT/mTOR network for treatment of leukemia
- (2015) Jessika Bertacchini et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma
- (2015) A. Gupte et al. CLINICAL CANCER RESEARCH
- MicroRNA-126 suppresses proliferation of undifferentiated (BRAFV600E and BRAFWT) thyroid carcinoma through targeting PIK3R2 gene and repressing PI3K-AKT proliferation-survival signalling pathway
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- New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals
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- NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling
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- KITandPDGFRAMutations and the Risk of GI Stromal Tumor Recurrence
- (2015) Heikki Joensuu et al. JOURNAL OF CLINICAL ONCOLOGY
- Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
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- INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia
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- Hodgkin Lymphoma: Diagnosis and Treatment
- (2015) Stephen M. Ansell MAYO CLINIC PROCEEDINGS
- GPCR48/LGR4 promotes tumorigenesis of prostate cancer via PI3K/Akt signaling pathway
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- c-Met-mediated reactivation of PI3K/AKT signaling contributes to insensitivity of BRAF(V600E) mutant thyroid cancer to BRAF inhibition
- (2015) Hyung Kwon Byeon et al. MOLECULAR CARCINOGENESIS
- ROR1 contributes to melanoma cell growth and migration by regulating N-cadherin expression via the PI3K/Akt pathway
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- Integrated molecular analysis of adult T cell leukemia/lymphoma
- (2015) Keisuke Kataoka et al. NATURE GENETICS
- PIG3 plays an oncogenic role in papillary thyroid cancer by activating the PI3K/AKT/PTEN pathway
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- PTEN and PI3K/AKT in non-small-cell lung cancer
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- PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion
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- Lymphomagenesis in Hodgkin lymphoma
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- In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes
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- Snail promotes cell migration through PI3K/AKT-dependent Rac1 activation as well as PI3K/AKT-independent pathways during prostate cancer progression
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- CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration
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- SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway
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- Mutations in PI3K/AKT pathway genes and amplifications of PIK3CA are associated with patterns of recurrence in gastric cancers
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- PIK3R1 negatively regulates the epithelial-mesenchymal transition and stem-like phenotype of renal cancer cells through the AKT/GSK3β/CTNNB1 signaling pathway
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- Adaptive Mitochondrial Reprogramming and Resistance to PI3K Therapy
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- Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells
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- MicroRNA-122 Promotes Proliferation, Invasion and Migration of Renal Cell Carcinoma Cells Through the PI3K/Akt Signaling Pathway
- (2014) Ji-Hu Lian et al. Asian Pacific Journal of Cancer Prevention
- The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma
- (2014) A. Spencer et al. BLOOD
- Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma
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- PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform
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- Should small papillary thyroid cancer be observed? A population-based study
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- MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer
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- Phase I study of the MEK inhibitor trametinib in combination with the AKT inhibitor afuresertib in patients with solid tumors and multiple myeloma
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- FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway
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- Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition
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- Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence
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- Presence of Somatic Mutations within PIK3CA, AKT, RAS, and FGFR3 but not BRAF in Cisplatin-Resistant Germ Cell Tumors
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- miR-145 suppresses thyroid cancer growth and metastasis and targets AKT3
- (2014) Myriem Boufraqech et al. ENDOCRINE-RELATED CANCER
- PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells
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- miR-137 effects on gastric carcinogenesis are mediated by targeting Cox-2-activated PI3K/AKT signaling pathway
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- Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α
- (2014) Romain Baer et al. GENES & DEVELOPMENT
- Activation of the PI3K/AKT pathway by microRNA-22 results in CLL B-cell proliferation
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- Down-regulation of miR-29c in human bladder cancer and the inhibition of proliferation in T24 cell via PI3K-AKT pathway
- (2014) Yanru Fan et al. MEDICAL ONCOLOGY
- Activating BRAF and PIK3CA Mutations Cooperate to Promote Anaplastic Thyroid Carcinogenesis
- (2014) Roch-Philippe Charles et al. MOLECULAR CANCER RESEARCH
- SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer
- (2014) Jessica A. Gasser et al. MOLECULAR CELL
- Genomic and molecular characterization of esophageal squamous cell carcinoma
- (2014) De-Chen Lin et al. NATURE GENETICS
- PI3Kδ Inhibition by Idelalisib in Patients with Relapsed Indolent Lymphoma
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- MicroRNA-497 suppresses angiogenesis by targeting vascular endothelial growth factor A through the PI3K/AKT and MAPK/ERK pathways in ovarian cancer
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- Activated α2-Macroglobulin Binding to Cell Surface GRP78 Induces T-Loop Phosphorylation of Akt1 by PDK1 in Association with Raptor
- (2014) Uma Kant Misra et al. PLoS One
- Targeting Class IA PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma
- (2014) Katrin Höland et al. PLoS One
- Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
- (2014) Jennifer A. Perry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PI3′-Kinase Inhibition Forestalls the Onset of MEK1/2 Inhibitor Resistance in BRAF -Mutated Melanoma
- (2014) Marian M. Deuker et al. Cancer Discovery
- Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study
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- Genetics of Follicular Lymphoma Transformation
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- MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway
- (2013) Yanfei Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate
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- The Somatic Genomic Landscape of Glioblastoma
- (2013) Cameron W. Brennan et al. CELL
- Roles for KRAS in Pancreatic Tumor Development and Progression
- (2013) Marina Pasca di Magliano et al. GASTROENTEROLOGY
- Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma
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- Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application
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- PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma
- (2013) M. Pfeifer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway
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- An Unholy Alliance: Cooperation between BRAF and NF1 in Melanoma Development and BRAF Inhibitor Resistance
- (2013) Geoffrey T. Gibney et al. Cancer Discovery
- Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers
- (2013) V. W. Y. Lui et al. Cancer Discovery
- Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway
- (2012) Y. Li et al. BLOOD
- Perifosine plus lenalidomide and dexamethasone in relapsed and relapsed/refractory multiple myeloma: a Phase I Multiple Myeloma Research Consortium study
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- Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways
- (2012) Shunsuke Noguchi et al. CANCER LETTERS
- Tumor suppressor functions of FBW7 in cancer development and progression
- (2012) Zhiwei Wang et al. FEBS LETTERS
- Pancreatic Cancer Screening
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- Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells
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- Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region
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- MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma
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- Hodgkin lymphoma
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- CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009
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- Resequencing analysis of the candidate tyrosine kinase and RAS pathway gene families in multiple myeloma
- (2012) Vishwanathan Hucthagowder et al. Cancer Genetics
- GS-1101: A Delta-Specific PI3K Inhibitor in Chronic Lymphocytic Leukemia
- (2012) Ines M. Macias-Perez et al. Current Hematologic Malignancy Reports
- Akt and mTOR in B Cell Activation and Differentiation
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- A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types
- (2011) Stephen Jamieson et al. BIOCHEMICAL JOURNAL
- AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
- (2011) Sarat Chandarlapaty et al. CANCER CELL
- Genetic and Epigenetic Alterations in Pancreatic Carcinogenesis
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- The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion
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- Perifosine Plus Bortezomib and Dexamethasone in Patients With Relapsed/Refractory Multiple Myeloma Previously Treated With Bortezomib: Results of a Multicenter Phase I/II Trial
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- Silencing of ETV6/RUNX1 abrogates PI3K/AKT/mTOR signaling and impairs reconstitution of leukemia in xenografts
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- Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
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- The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
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- NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma
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- PI3K Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic
- (2011) D. A. Fruman et al. Cancer Discovery
- The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory
- (2010) Robert J. Kurman et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Prioritization of driver mutations in pancreatic cancer using cancer-specific high-throughput annotation of somatic mutations (CHASM)
- (2010) Hannah Carter et al. CANCER BIOLOGY & THERAPY
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
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- Targeting of Leukemia-Initiating Cells to Develop Curative Drug Therapies: Straightforward but Nontrivial Concept
- (2010) P. Valent CURRENT CANCER DRUG TARGETS
- Phosphoinositide-3-Kinase Inhibition Enhances Radiosensitization of Cervical Cancer In Vivo
- (2010) Yi Liu et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts
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- Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase
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- Phosphatidylinositol 3-Kinase Signaling in Thymocytes: The Need for Stringent Control
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- Genetic Alterations in the Phosphatidylinositol-3 Kinase/Akt Pathway in Thyroid Cancer
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- Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma
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- Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models
- (2009) C.-N. Qian et al. CANCER RESEARCH
- Hotspot mutations of PIK3CA and AKT1 genes are absent in multiple myeloma
- (2009) Said I. Ismail et al. LEUKEMIA RESEARCH
- Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells
- (2009) Hui-Fang Li et al. Radiation Oncology
- The Fbxw7/hCdc4 tumor suppressor in human cancer
- (2008) YingMeei Tan et al. CANCER LETTERS
- PIK3IP1, a Negative Regulator of PI3K, Suppresses the Development of Hepatocellular Carcinoma
- (2008) X. He et al. CANCER RESEARCH
- PI3K pathway alterations in cancer: variations on a theme
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- Laryngeal Cancer: Diagnosis and Preoperative Work-up
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