NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

Mouse Genome Engineering via CRISPR-Cas9 for Study of Immune Function

(2015) Stephane Pelletier et al.   IMMUNITY

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

(2014) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies

(2014) Lise Boussemart et al.   NATURE

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development

(2013) Celia E. Shiau et al.   Cell Reports

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

Molecular signatures of a disturbed nasal barrier function in the primary tissue of Wegener's granulomatosis

(2011) M Laudien et al.   Mucosal Immunology

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY