Tumor suppressor functions of FBW7 in cancer development and progression

GSK-3  regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1 

(2011) D. Flugel et al.   BLOOD

MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression

(2011) Mikael Lerner et al.   CELL CYCLE

SAG/RBX2/ROC2 E3 Ubiquitin Ligase Is Essential for Vascular and Neural Development by Targeting NF1 for Degradation

(2011) Mingjia Tan et al.   DEVELOPMENTAL CELL

The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase

(2011) Mi-Yeon Kim et al.   EXPERIMENTAL CELL RESEARCH

Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells

(2011) Akinobu Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fbw7 Tumor Suppressor Regulates Nuclear Factor E2-related Factor 1 Transcription Factor Turnover through Proteasome-mediated Proteolysis

(2011) Madhurima Biswas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulation of HIF-1α by an FBW7-mediated degradation pathway during hypoxia

(2011) Jessica M. Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia

(2011) Sonya M. Diakiw et al.   LEUKEMIA RESEARCH

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

(2011) Hiroyuki Inuzuka et al.   NATURE

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

(2011) Allan M. Weissman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell cyclins: triggering elements of cancer or not?

(2011) Michael Stamatakos et al.   World Journal of Surgical Oncology

The Fbw7 Tumor Suppressor Targets KLF5 for Ubiquitin-Mediated Degradation and Suppresses Breast Cell Proliferation

(2010) Dong Zhao et al.   CANCER RESEARCH

Fbxw7 in cell cycle exit and stem cell maintenance: Insight from gene-targeted mice

(2010) Ichiro Onoyama et al.   CELL CYCLE

Notch Signaling Proteins: Legitimate Targets for Cancer Therapy

(2010) Zhiwei Wang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

(2010) Kuppusamy Balamurugan et al.   EMBO JOURNAL

Mcl-1; the molecular regulation of protein function

(2010) Luke W. Thomas et al.   FEBS LETTERS

F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor

(2010) Rocio Sancho et al.   GASTROENTEROLOGY

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-223 Regulates Cyclin E Activity by Modulating Expression of F-box and WD-40 Domain Protein 7

(2010) Yanfei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum- and glucocorticoid-inducible kinase 1 (SGK1) controls Notch1 signaling by downregulation of protein stability through Fbw7 ubiquitin ligase

(2010) J.-S. Mo et al.   JOURNAL OF CELL SCIENCE

Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia

(2010) Dan-Dan Feng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

(2010) Ichiro Onoyama et al.   JOURNAL OF CLINICAL INVESTIGATION

The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans

(2010) V. T. Phan et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

(2010) V Rocher-Ros et al.   ONCOGENE

GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms

(2010) Kyoko Kitagawa et al.   Cell Division

Proteasomal and Genetic Inactivation of the NF1 Tumor Suppressor in Gliomagenesis

(2009) Lauren T. McGillicuddy et al.   CANCER CELL

p53-Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases

(2009) T. Yokobori et al.   CANCER RESEARCH

Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy

(2009) L. Fu et al.   CANCER RESEARCH

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

(2009) Jin-Tang Dong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts

(2009) K Masuda et al.   ONCOGENE

Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb

(2009) K Kitagawa et al.   ONCOGENE

Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1

(2009) H -Q Zheng et al.   ONCOGENE

Role of Nrf1 in antioxidant response element-mediated gene expression and beyond

(2009) Madhurima Biswas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Fbxw7 Acts as an E3 Ubiquitin Ligase That Targets c-Myb for Nemo-like Kinase (NLK)-induced Degradation

(2008) Chie Kanei-Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

(2008) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias

(2008) Jee Hoon Song et al.   LEUKEMIA RESEARCH

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

(2008) Y Ishikawa et al.   ONCOGENE

Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy

(2008) S Finkin et al.   ONCOGENE

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE