PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K/AKT in lymphoma cells

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CUDC-907 in relapsed/refractory diffuse large B-cell lymphoma, including patients with MYC-alterations: results from an expanded phase I trial

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EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

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Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia

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FBXO10 deficiency and BTK activation upregulate BCL2 expression in mantle cell lymphoma

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Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth

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Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

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Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis

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MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

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Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

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Protein Arginine Methyltransferase 5 (PRMT5) Inhibition Induces Lymphoma Cell Death through Reactivation of the Retinoblastoma Tumor Suppressor Pathway and Polycomb Repressor Complex 2 (PRC2) Silencing

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Overexpression of PRMT5 Promotes Tumor Cell Growth and Is Associated with Poor Disease Prognosis in Epithelial Ovarian Cancer

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PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

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PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

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Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

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Arginine methylation controls growth regulation by E2F-1

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Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

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Analysis of the coding genome of diffuse large B-cell lymphoma

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Versatility of PRMT5-induced methylation in growth control and development

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Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

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PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Arginine methylation regulates the p53 response

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Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma

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