Regulation of PI3K signaling in T-cell acute lymphoblastic leukemia: a novel PTEN/Ikaros/miR-26b mechanism reveals a critical targetable role for PIK3CD

MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-κB/MMP-9/VEGF pathways

(2016) Dongmei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miRNA-149* promotes cell proliferation and suppresses apoptosis by mediating JunB in T-cell acute lymphoblastic leukemia

(2016) Sheng-jin Fan et al.   LEUKEMIA RESEARCH

miR-590 promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia by inhibiting RB1

(2016) Mei-hua Miao et al.   Oncotarget

miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia

(2015) Hong Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies

(2015) M. Mamonkin et al.   BLOOD

Potential roles of microRNA-29a in the molecular pathophysiology of T-cell acute lymphoblastic leukemia

(2015) Lucila H. Oliveira et al.   CANCER SCIENCE

Upregulation of miRNA-17 and miRNA-19 is associated with unfavorable prognosis in patients with T-cell lymphoblastic lymphoma

(2015) Yanfeng Xi et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression

(2015) W.D. Zheng et al.   GENETICS AND MOLECULAR RESEARCH

microRNA-181a enhances cell proliferation in acute lymphoblastic leukemia by targeting EGR1

(2015) Lorena Verduci et al.   LEUKEMIA RESEARCH

Phosphoinositide 3’-kinase delta: turning off BCR signaling in Chronic Lymphocytic Leukemia.

(2015)   Oncotarget

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

(2014) E. Mets et al.   HAEMATOLOGICA

Prognostic impact of microRNA-145 down-regulation in adult T-cell leukemia/lymphoma

(2014) Hongjing Xia et al.   HUMAN PATHOLOGY

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

(2014) E Mets et al.   LEUKEMIA

A microRNA-mediated regulatory loop modulates NOTCH and MYC oncogenic signals in B- and T-cell malignancies

(2014) M Ortega et al.   LEUKEMIA

miR-2909-mediated regulation of KLF4: a novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemias

(2014) Deepti Malik et al.   Molecular Cancer

MicroRNA-26b Represses Colon Cancer Cell Proliferation by Inhibiting Lymphoid Enhancer Factor 1 Expression

(2014) Z. Zhang et al.   MOLECULAR CANCER THERAPEUTICS

The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells

(2014) A.-S. Geimer Le Lay et al.   Science Signaling

Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

(2014) V. R. Sanghvi et al.   Science Signaling

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(2013) Eric C. Hales et al.   CELLULAR SIGNALLING

Direct Protein Interactions Are Responsible for Ikaros-GATA and Ikaros-Cdk9 Cooperativeness in Hematopoietic Cells

(2013) Stefania Bottardi et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros

(2013) Hilde Schjerven et al.   NATURE IMMUNOLOGY

The Combined Expression Patterns of Ikaros Isoforms Characterize Different Hematological Tumor Subtypes

(2013) Carlos A. Orozco et al.   PLoS One

Targeting Nonclassical Oncogenes for Therapy in T-ALL

(2012) Prem S. Subramaniam et al.   CANCER CELL

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

(2012) Alabbas Alkhatib et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia

(2012) Huashan Ye et al.   NUCLEIC ACIDS RESEARCH

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

(2011) Konstantinos J Mavrakis et al.   NATURE GENETICS

Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223

(2010) S. Chiaretti et al.   HAEMATOLOGICA

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

(2009) H. Medyouf et al.   BLOOD

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

(2009) A. Gutierrez et al.   BLOOD

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

(2009) D. I. Marks et al.   BLOOD

SnapShot: MicroRNAs in Cancer

(2009) Riccardo Spizzo et al.   CELL

Targeted therapy in T-cell malignancies: dysregulation of the cellular signaling pathways

(2009) W-L Zhao   LEUKEMIA

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia

(2008) D Schotte et al.   LEUKEMIA

MicroRNA expression profiling using microarrays

(2008) Chang-Gong Liu et al.   Nature Protocols