GS-1101: A Delta-Specific PI3K Inhibitor in Chronic Lymphocytic Leukemia
Published 2012 View Full Article
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Title
GS-1101: A Delta-Specific PI3K Inhibitor in Chronic Lymphocytic Leukemia
Authors
Keywords
Signaling pathways, B-cell receptor, BCR, Chronic lymphocytic leukemia, CLL, New targets, PI3-Kinase, CAL-101, GS-1101, PI3K delta, PI3K, Microenvironment
Journal
Current Hematologic Malignancy Reports
Volume 8, Issue 1, Pages 22-27
Publisher
Springer Nature
Online
2012-11-01
DOI
10.1007/s11899-012-0142-1
References
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Related references
Note: Only part of the references are listed.- Novel Targeted Agents and the Need to Refine Clinical End Points in Chronic Lymphocytic Leukemia
- (2012) Bruce D. Cheson et al. JOURNAL OF CLINICAL ONCOLOGY
- The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
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- SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
- (2011) Lili Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
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- The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia
- (2010) Y. Herishanu et al. BLOOD
- Phosphatidylinositol 3-kinase- inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
- (2010) S. E. M. Herman et al. BLOOD
- Drugging the PI3 Kinome: From Chemical Tools to Drugs in the Clinic
- (2010) P. Workman et al. CANCER RESEARCH
- The emerging mechanisms of isoform-specific PI3K signalling
- (2010) Bart Vanhaesebroeck et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The microenvironment in mature B-cell malignancies: a target for new treatment strategies
- (2009) J. A. Burger et al. BLOOD
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- (2009) J. W. Friedberg et al. BLOOD
- Targeting the PI3K signaling pathway in cancer
- (2009) Kwok-Kin Wong et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation
- (2008) J. A. Burger et al. BLOOD
- Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation
- (2008) P. Ghia et al. JOURNAL OF INTERNAL MEDICINE
- Drug discovery approaches targeting the PI3K/Akt pathway in cancer
- (2008) C Garcia-Echeverria et al. ONCOGENE
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