Glyoxalase 2 Is Involved in Human Prostate Cancer Progression as Part of a Mechanism Driven By PTEN/PI3K/AKT/mTOR Signaling With Involvement of PKM2 and ERα

Cotargeting Androgen Receptor Splice Variants and mTOR Signaling Pathway for the Treatment of Castration-Resistant Prostate Cancer

(2015) M. Kato et al.   CLINICAL CANCER RESEARCH

Regulation of vascular endothelial growth factor in prostate cancer

(2015) S. de Brot et al.   ENDOCRINE-RELATED CANCER

PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug

(2015) Tiantian He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

(2015) Sophia Y. Lunt et al.   MOLECULAR CELL

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread

(2015) Elisa Giannoni et al.   Oncotarget

Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells

(2015) Pamela J. Maxwell et al.   Oncotarget

Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB

(2014) C Antognelli et al.   BRITISH JOURNAL OF CANCER

Changes in PKM2 Associate with Prostate Cancer Progression

(2014) Nicholas Wong et al.   CANCER INVESTIGATION

Estradiol-17β Upregulates Pyruvate Kinase M2 Expression to Coactivate Estrogen Receptor-α and to Integrate Metabolic Reprogramming With the Mitogenic Response in Endometrial Cells

(2014) Salama A. Salama et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

(2014) Dimple Chakravarty et al.   Nature Communications

Glyoxalase I in Tumor Cell Proliferation and Survival and as a Potential Target for Anticancer Therapy

(2014) Xiaofang Geng et al.   Oncology Research and Treatment

Reactive oxygen species induce apoptosis in bronchial epithelial BEAS-2B cells by inhibiting the antiglycation glyoxalase I defence: involvement of superoxide anion, hydrogen peroxide and NF-κB

(2013) Cinzia Antognelli et al.   APOPTOSIS

The glyoxalase pathway: the first hundred years… and beyond

(2013) Marta Sousa Silva et al.   BIOCHEMICAL JOURNAL

S-D-Lactoylglutathione can be an alternative supply of mitochondrial glutathione

(2013) Tatiana Armeni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals

(2013) Xueliang Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring glyoxalase 1 expression in prostate cancer tissues: Targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties

(2013) Martin Baunacke et al.   PROSTATE

Loss of Transforming Growth Factor Beta Type II Receptor Increases Aggressive Tumor Behavior and Reduces Survival in Lung Adenocarcinoma and Squamous Cell Carcinoma

(2012) S. P. Malkoski et al.   CLINICAL CANCER RESEARCH

Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer

(2012) Michael W. Hance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

(2012) Xueliang Gao et al.   MOLECULAR CELL

Phospho-Akt Immunoreactivity in Prostate Cancer: Relationship to Disease Severity and Outcome, Ki67 and Phosphorylated EGFR Expression

(2012) Peter Hammarsten et al.   PLoS One

Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells

(2012) Cinzia Antognelli et al.   PROSTATE

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

(2011) David J. Mulholland et al.   CANCER CELL

Up-Regulation of Sonic Hedgehog Contributes to TGF-β1-Induced Epithelial to Mesenchymal Transition in NSCLC Cells

(2011) Ma'in Y. Maitah et al.   PLoS One

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

BZL101, a phytochemical extract from theScutellaria barbataplant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

(2010) Crystal N. Marconett et al.   CANCER BIOLOGY & THERAPY

Transcriptional coactivators p300 and CBP stimulate estrogen receptor-beta signaling and regulate cellular events in prostate cancer

(2010) Jan Bouchal et al.   PROSTATE

Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17 -Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy

(2009) H. Chen et al.   DRUG METABOLISM AND DISPOSITION

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

PTEN and the PI3-Kinase Pathway in Cancer

(2008) Nader Chalhoub et al.   Annual Review of Pathology-Mechanisms of Disease

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE