EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia

iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL

(2018) Michael Hallek et al.   BLOOD

Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression

(2017) Qin-nan Chen et al.   Molecular Cancer

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

(2017) BaoHan T. Vo et al.   Cell Reports

Epigenetic silencing of miR-26A1 in chronic lymphocytic leukemia and mantle cell lymphoma: Impact on EZH2 expression

(2016) Pradeep Kumar Kopparapu et al.   Epigenetics

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia

(2016) Nikos Papakonstantinou et al.   Oncotarget

Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLL

(2016) Santhilal Subhash et al.   Clinical Epigenetics

Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia

(2015) Doralina do Amaral Rabello et al.   BLOOD CELLS MOLECULES AND DISEASES

MCPH1 maintains long-term epigenetic silencing ofANGPT2in chronic lymphocytic leukemia

(2015) Pradeep Kumar Kopparapu et al.   FEBS Journal

Insulin Growth Factor 1 Receptor Expression Is Associated with NOTCH1 Mutation, Trisomy 12 and Aggressive Clinical Course in Chronic Lymphocytic Leukaemia

(2015) Francesco Maura et al.   PLoS One

Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms

(2015) Cheryl M. Koh et al.   Oncotarget

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia

(2014) J. R. Brown et al.   BLOOD

Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression

(2014) Gamze Kuser-Abali et al.   Epigenetics

Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia

(2014) Richard R. Furman et al.   NEW ENGLAND JOURNAL OF MEDICINE

ChIP-Enrich: gene set enrichment testing for ChIP-seq data

(2014) Ryan P. Welch et al.   NUCLEIC ACIDS RESEARCH

Regulation and Role of EZH2 in Cancer

(2014) Hirohito Yamaguchi et al.   Cancer Research and Treatment

NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets

(2013) Marcus R. Breese et al.   BIOINFORMATICS

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia

(2013) N. Yaktapour et al.   BLOOD

A key role for EZH2 in epigenetic silencing of HOX genes in mantle cell lymphoma

(2013) Meena Kanduri et al.   Epigenetics

Transcriptome characterization by RNA sequencing identifies a major molecular and clinical subdivision in chronic lymphocytic leukemia

(2013) P. G. Ferreira et al.   GENOME RESEARCH

Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity

(2013) X Zhao et al.   LEUKEMIA

Unknown

(2013) Nikos Papakonstantinou et al.   MOLECULAR MEDICINE

Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

(2012) Xinwei Zhang et al.   CANCER CELL

Interactions between bone marrow stromal microenvironment and B-chronic lymphocytic leukemia cells: Any role for Notch, Wnt and Hh signaling pathways?

(2012) Paul Faustin Seke Etet et al.   CELLULAR SIGNALLING

Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells

(2012) W. Fiskus et al.   CLINICAL CANCER RESEARCH

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

(2012) Michael T. McCabe et al.   NATURE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent

(2012) K. Xu et al.   SCIENCE

Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection

(2012) Anders Rosén et al.   OncoImmunology

EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-β-Catenin Signaling

(2011) Chun-Ju Chang et al.   CANCER CELL

Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma

(2011) D. Vishwamitra et al.   HAEMATOLOGICA

Context-Specific Regulation of NF-κB Target Gene Expression by EZH2 in Breast Cancers

(2011) Shuet Theng Lee et al.   MOLECULAR CELL

A unique chromatin signature uncovers early developmental enhancers in humans

(2010) Alvaro Rada-Iglesias et al.   NATURE

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation

(2009) T. B. Miranda et al.   MOLECULAR CANCER THERAPEUTICS

CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells

(2009) Xiaojing Yang et al.   PLoS One

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a

(2008) S. Sander et al.   BLOOD

The effect of FK506 on transforming growth factor   signaling and apoptosis in chronic lymphocytic leukemia B cells

(2008) S. Romano et al.   HAEMATOLOGICA

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

(2008) Bora Gurel et al.   MODERN PATHOLOGY