Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models

Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis

(2019) Hoibin Jeong et al.   CANCER RESEARCH

Photo-Cured Glycol Chitosan Hydrogel for Ovarian Cancer Drug Delivery

(2019) Hoon Hyun et al.   Marine Drugs

Modeling Tumor Phenotypes In Vitro with Three-Dimensional Bioprinting

(2019) Ellen M. Langer et al.   Cell Reports

Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel

(2019) Jian Zhou et al.   Microsystems & Nanoengineering

Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment

(2019) Tristan Courau et al.   Journal for ImmunoTherapy of Cancer

Collagen density regulates the activity of tumor-infiltrating T cells

(2019) Dorota E. Kuczek et al.   Journal for ImmunoTherapy of Cancer

Evaluating CAR-T Cell Therapy in a Hypoxic 3D Tumor Model

(2019) Yuta Ando et al.   Advanced Healthcare Materials

Alteration of specific cytokine expression patterns in patients with breast cancer

(2019) Kosuke Kawaguchi et al.   Scientific Reports

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

(2019) Wai Hoong Chang et al.   Journal of Translational Medicine

Human colon organoids reveal distinct physiologic and oncogenic Wnt responses

(2019) Birgitta E. Michels et al.   JOURNAL OF EXPERIMENTAL MEDICINE

3D models in the new era of immune oncology: focus on T cells, CAF and ECM

(2019) Francesca Di Modugno et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

(2019) Flora Cimmino et al.   BMC Medical Genetics

3D-Bioprinted Mini-Brain: A Glioblastoma Model to Study Cellular Interactions and Therapeutics

(2019) Marcel Alexander Heinrich et al.   ADVANCED MATERIALS

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity

(2019) Pit Ullmann et al.   CANCER LETTERS

A human organotypic microfluidic tumor model permits investigation of the interplay between patient-derived fibroblasts and breast cancer cells

(2019) Danh D Truong et al.   CANCER RESEARCH

Development of a patient-derived xenograft model of glioblastoma via intravitreal injection in mice

(2019) Jooyoung Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Adaptive Changes of Glioblastoma Cells Following Exposure to Hypoxic (1% Oxygen) Tumour Microenvironment

(2019) Ahmed Musah-Eroje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Organoid culture containing cancer cells and stromal cells reveals that podoplanin-positive cancer-associated fibroblasts enhance proliferation of lung cancer cells

(2019) Hiroshi Nakamura et al.   LUNG CANCER

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Short-term 3D culture systems of various complexity for treatment optimization of colorectal carcinoma

(2019) Marloes Zoetemelk et al.   Scientific Reports

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

(2019) Yoshimasa Saito et al.   Cell Reports

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

(2019) M. R. Carvalho et al.   Science Advances

The Interplay of Autophagy and Tumor Microenvironment in Colorectal Cancer—Ways of Enhancing Immunotherapy Action

(2019) Evangelos Koustas et al.   Cancers

Hypoxia signaling in human diseases and therapeutic targets

(2019) Jae W. Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors

(2019) Michael P. Hay et al.   MOLECULES

Integrated cancer tissue engineering models for precision medicine

(2019) Michael E. Bregenzer et al.   PLoS One

Scaffold-based lung tumor culture on porous PLGA microparticle substrates

(2019) Aneetta E. Kuriakose et al.   PLoS One

Distinct Vulnerability and Resilience of Human Neuroprogenitor Subtypes in Cerebral Organoid Model of Prenatal Hypoxic Injury

(2019) Nicolas Daviaud et al.   Frontiers in Cellular Neuroscience

A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids

(2019) John A. Reid et al.   Scientific Reports

Assembly of Human Stem Cell-Derived Cortical Spheroids and Vascular Spheroids to Model 3-D Brain-like Tissues

(2019) Liqing Song et al.   Scientific Reports

3D Microfluidic Bone Tumor Microenvironment Comprised of Hydroxyapatite/Fibrin Composite

(2019) Jungho Ahn et al.   Frontiers in Bioengineering and Biotechnology

Fast 3-D Imaging of Brain Organoids With a New Single-Objective Planar-Illumination Two-Photon Microscope

(2019) Irina Rakotoson et al.   Frontiers in Neuroanatomy

Three‐dimensional cryogel matrix for spheroid formation and anti‐cancer drug screening

(2019) Archana Singh et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

(2019) Disha Sood et al.   Nature Communications

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

(2019) Minsuh Kim et al.   Nature Communications

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

(2019) Inês Godet et al.   Nature Communications

Patient-derived scaffolds uncover breast cancer promoting properties of the microenvironment

(2019) Göran Landberg et al.   BIOMATERIALS

Characterization and printability of Sodium alginate -Gelatin hydrogel for bioprinting NSCLC co-culture

(2019) Arindam Mondal et al.   Scientific Reports

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

(2019) Gabriella Nilsson Hall et al.   Advanced Science

Hybrid collagen alginate hydrogel as a platform for 3D tumor spheroid invasion

(2018) Chun Liu et al.   Acta Biomaterialia

3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment

(2018) Sofia P. Rebelo et al.   BIOMATERIALS

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Development of a 3D bone marrow adipose tissue model

(2018) Heather Fairfield et al.   BONE

Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies

(2018) Jill A. Gallaher et al.   CANCER RESEARCH

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Cancer initiation and progression within the cancer microenvironment

(2018) Stanley P. Leong et al.   CLINICAL & EXPERIMENTAL METASTASIS

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma

(2018) Yeonhwa Song et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Method of the Year 2017: Organoids

(2018)   NATURE METHODS

Rapidly responsive silk fibroin hydrogels as an artificial matrix for the programmed tumor cells death

(2018) Viviana P. Ribeiro et al.   PLoS One

Establishment of patient-derived tumor spheroids for non-small cell lung cancer

(2018) Zengli Zhang et al.   PLoS One

The role of HIF-1α in chemo-/radioresistant tumors

(2018) Yu Xia et al.   OncoTargets and Therapy

3D printing of high-strength bioscaffolds for the synergistic treatment of bone cancer

(2018) Hongshi Ma et al.   NPG Asia Materials

Collagen-based three-dimensional culture microenvironment promotes epithelial to mesenchymal transition and drug resistance of human ovarian cancer in vitro

(2018) Ming Liu et al.   RSC Advances

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening

(2018) Andrea R. Mazzocchi et al.   Scientific Reports

A new cell-laden 3D Alginate-Matrigel hydrogel resembles human breast cancer cell malignant morphology, spread and invasion capability observed “in vivo”

(2018) Marta Cavo et al.   Scientific Reports

A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity

(2018) Hilary Sherman et al.   Frontiers in Immunology

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

(2018) Linda Ziani et al.   Frontiers in Immunology

Rapid 3D bioprinting of decellularized extracellular matrix with regionally varied mechanical properties and biomimetic microarchitecture

(2018) Xuanyi Ma et al.   BIOMATERIALS

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Three-Dimensional Ameliorated Biologics Elicit Thymic Renewal in Tumor-Bearing Hosts

(2018) Yanna Zhang et al.   JOURNAL OF IMMUNOLOGY

The Different Routes to Metastasis via Hypoxia-Regulated Programs

(2018) Ana Rita Nobre et al.   TRENDS IN CELL BIOLOGY

Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening

(2018) T. J. Puls et al.   Scientific Reports

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Three-Dimensional In Vitro Hydro- and Cryogel-Based Cell-Culture Models for the Study of Breast-Cancer Metastasis to Bone

(2018) Laura Bray et al.   Cancers

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

(2018) Ana S. Nunes et al.   BIOTECHNOLOGY AND BIOENGINEERING

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation

(2018) Jes�s Valencia‑Cervantes et al.   ONCOLOGY REPORTS

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

(2018) Irena Kaplanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines

(2018) Jiho Song et al.   Scientific Reports

A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer

(2018) Sabra I. Djomehri et al.   Journal of Cell Communication and Signaling

A Dynamic Culture Method to Produce Ovarian Cancer Spheroids under Physiologically-Relevant Shear Stress

(2018) Timothy Masiello et al.   Cells

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

(2017) Dimakatso Alice Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

(2017) Stephen Riffle et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo

(2017) Daniel M Lewis et al.   Nature Protocols

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

(2017) Gianpiero Lazzari et al.   Polymer Chemistry

The era of 3Rs implementation in developmental and reproductive toxicity (DART) testing: Current overview and future perspectives

(2017) Manon Beekhuijzen   REPRODUCTIVE TOXICOLOGY

Three‑dimensional cell culture: A powerful tool in tumor research and drug discovery (Review)

(2017) Donglai Lv et al.   Oncology Letters

A bioprosthetic ovary created using 3D printed microporous scaffolds restores ovarian function in sterilized mice

(2017) Monica M. Laronda et al.   Nature Communications

Application of 3D tumoroid systems to define immune and cytotoxic therapeutic responses based on tumoroid and tissue slice culture molecular signatures

(2017) Niklas K. Finnberg et al.   Oncotarget

Novel “Elements” of Immune Suppression within the Tumor Microenvironment

(2017) Devikala Gurusamy et al.   Cancer Immunology Research

Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine

(2017) Maria Jeppesen et al.   PLoS One

Hypoxia and hypoxia-inducible factor (HIF) downregulate antigen-presenting MHC class I molecules limiting tumor cell recognition by T cells

(2017) Shalini Sethumadhavan et al.   PLoS One

Engineering a vascularised 3D in vitro model of cancer progression

(2017) Tarig Magdeldin et al.   Scientific Reports

A Glycyrrhetinic Acid-Modified Curcumin Supramolecular Hydrogel for liver tumor targeting therapy

(2017) Guoqin Chen et al.   Scientific Reports

Hanging Drop, A Best Three-Dimensional (3D) Culture Method for Primary Buffalo and Sheep Hepatocytes

(2017) Meena Shri et al.   Scientific Reports

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

(2016) Zheng Zhao et al.   LAB ON A CHIP

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium

(2016) Beth A. Lindborg et al.   Stem Cells Translational Medicine

T Cells and Cancer: How Metabolism Shapes Immunity

(2016) Barbara Molon et al.   Frontiers in Immunology

3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma

(2015) Pilar de la Puente et al.   BIOMATERIALS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Bioengineering mini functional thymic units with EAK16-II/EAKIIH6 self-assembling hydrogel

(2015) Asako Tajima et al.   CLINICAL IMMUNOLOGY

Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts

(2015) Yong Fan et al.   MOLECULAR THERAPY

Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation

(2015) Giuseppe Mazza et al.   Scientific Reports

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

(2014) Stephen M. Hatfield et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Role of Hypoxia and Exploitation of the Hypoxic Environment in Hematologic Malignancies

(2014) Barbara Muz et al.   MOLECULAR CANCER RESEARCH

Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres

(2014) Anjana Jain et al.   NATURE MATERIALS

Imaging Tumor Hypoxia to Advance Radiation Oncology

(2013) Chen-Ting Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

(2013) E. L. Pearce et al.   SCIENCE

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

New Insight into the SDF-1/CXCR4 Axis in a Breast Carcinoma Model: Hypoxia-Induced Endothelial SDF-1 and Tumor Cell CXCR4 Are Required for Tumor Cell Intravasation

(2012) F. Jin et al.   MOLECULAR CANCER RESEARCH

The role of the myofibroblast in tumor stroma remodeling

(2012) Marcela Otranto et al.   Cell Adhesion & Migration

Spontaneous spheroid budding from monolayers: a potential contribution to ovarian cancer dissemination

(2012) J. C. Pease et al.   Biology Open

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Chemoattractant Signaling between Tumor Cells and Macrophages Regulates Cancer Cell Migration, Metastasis and Neovascularization

(2009) Chad E. Green et al.   PLoS One

Are animal models predictive for humans?

(2009) Niall Shanks et al.   Philosophy Ethics and Humanities in Medicine

Cancer and the tumor microenvironment: a review of an essential relationship

(2008) Flaubert Mbeunkui et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY