Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

Formation and repair of oxidatively generated damage in cellular DNA

(2017) Jean Cadet et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hypoxia and cellular metabolism in tumour pathophysiology

(2017) Scott K. Parks et al.   JOURNAL OF PHYSIOLOGY-LONDON

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

(2017) Iosifina P. Foskolou et al.   MOLECULAR CELL

Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer

(2017) Yang-An Wen et al.   Cell Death & Disease

Role of tumor microenvironment in tumorigenesis

(2017) Maonan Wang et al.   Journal of Cancer

The Eyes Absent Proteins in Developmental and Pathological Angiogenesis

(2016) Yuhua Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging

(2016) M. W. Dewhirst et al.   CANCER RESEARCH

Liquid-based three-dimensional tumor models for cancer research and drug discovery

(2016) Stephanie L Ham et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Hypoglycemia Enhances Epithelial-Mesenchymal Transition and Invasiveness, and Restrains the Warburg Phenotype, in Hypoxic HeLa Cell Cultures and Microspheroids

(2016) Álvaro Marín-Hernández et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

(2016) Marco Tafani et al.   Oxidative Medicine and Cellular Longevity

Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming

(2016) Silvia Selleri et al.   Oncotarget

Transcriptome profile of the early stages of breast cancer tumoral spheroids

(2016) Rosario Pacheco-Marín et al.   Scientific Reports

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

(2016) Kristin Stock et al.   Scientific Reports

Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids

(2016) Yeonhwa Song et al.   Scientific Reports

Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

(2015) Gry Irene Magnussen et al.   BMC CANCER

Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

(2015) Susan E. Scanlon et al.   DNA REPAIR

Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment

(2015) Mira Stadler et al.   SEMINARS IN CANCER BIOLOGY

Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

(2015) Maria A. Theodoraki et al.   Oncotarget

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Monitoring the Activation of the DNA Damage Response Pathway in a 3D Spheroid Model

(2015) Odile Mondesert et al.   PLoS One

A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography

(2014) T. H. Witney et al.   CANCER RESEARCH

The Meaning, Measurement and Modification of Hypoxia in the Laboratory and the Clinic

(2014) E.M. Hammond et al.   CLINICAL ONCOLOGY

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Radiation and ATM inhibition: the heart of the matter

(2014) Ester M. Hammond et al.   JOURNAL OF CLINICAL INVESTIGATION

A method for estimating the oxygen consumption rate in multicellular tumour spheroids

(2014) D. R. Grimes et al.   Journal of the Royal Society Interface

The Role of the HIF-1α Transcription Factor in Increased Cell Division at Physiological Oxygen Tensions

(2014) Samantha Carrera et al.   PLoS One

The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study

(2014) Sydney M. Evans et al.   Translational Oncology

Multiparameter analyses of three-dimensionally cultured tumor spheroids based on respiratory activity and comprehensive gene expression profiles

(2013) Yuanshu Zhou et al.   ANALYTICAL BIOCHEMISTRY

A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing

(2013) Derek Yip et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D

(2013) Jennifer Laurent et al.   BMC CANCER

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

Metabolic Alterations During the Growth of Tumour Spheroids

(2013) Katarzyna Bloch et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication

(2013) Monica M. Olcina et al.   MOLECULAR CELL

An integrated in vitro model of perfused tumor and cardiac tissue

(2013) Monica Moya et al.   Stem Cell Research & Therapy

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

(2012) Isabelle Dufau et al.   BMC CANCER

Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

(2012) Rama H Grantab et al.   BMC CANCER

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

(2012) I M Pires et al.   BRITISH JOURNAL OF CANCER

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Glucose Utilization via Glycogen Phosphorylase Sustains Proliferation and Prevents Premature Senescence in Cancer Cells

(2012) Elena Favaro et al.   Cell Metabolism

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

(2012) H. Yang et al.   CLINICAL CANCER RESEARCH

Advances in the formation, use and understanding of multi-cellular spheroids

(2012) Toni-Marie Achilli et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate

(2012) Chiara Riganti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

(2012) Yuji Okuno et al.   NATURE MEDICINE

Antiangiogenic Therapy for Cancer: An Update

(2012) Belal Al-Husein et al.   PHARMACOTHERAPY

A Heterogeneous In Vitro Three Dimensional Model of Tumour-Stroma Interactions Regulating Sprouting Angiogenesis

(2012) Pedro Correa de Sampaio et al.   PLoS One

Fibroblast EXT1-Levels Influence Tumor Cell Proliferation and Migration in Composite Spheroids

(2012) Cecilia Österholm et al.   PLoS One

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

(2012) Hiroshi Harada et al.   Nature Communications

Functional Interaction between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs

(2011) X. Tang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The rate of oxygen utilization by cells

(2011) Brett A. Wagner et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells

(2011) R. Guiet et al.   JOURNAL OF IMMUNOLOGY

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Harnessing synthetic lethal interactions in anticancer drug discovery

(2011) Denise A. Chan et al.   NATURE REVIEWS DRUG DISCOVERY

Down-Regulation of DNA Mismatch Repair Enhances Initiation and Growth of Neuroblastoma and Brain Tumour Multicellular Spheroids

(2011) Samuel L. Collins et al.   PLoS One

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr

(2011) Carlos A Fedrigo et al.   Radiation Oncology

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

3D imaging of the response to CDC25 inhibition in multicellular spheroids

(2010) Céline Frongia et al.   CANCER BIOLOGY & THERAPY

Effects of Acute versus Chronic Hypoxia on DNA Damage Responses and Genomic Instability

(2010) I. M. Pires et al.   CANCER RESEARCH

Contextual Synthetic Lethality of Cancer Cell Kill Based on the Tumor Microenvironment

(2010) N. Chan et al.   CANCER RESEARCH

"Contextual" Synthetic Lethality and/or Loss of Heterozygosity: Tumor Hypoxia and Modification of DNA Repair

(2010) N. Chan et al.   CLINICAL CANCER RESEARCH

Targeting Hypoxic Cells through the DNA Damage Response

(2010) M. Olcina et al.   CLINICAL CANCER RESEARCH

Roles of hypoxia-inducible factor-1α (HIF-1α) versus HIF-2α in the survival of hepatocellular tumor spheroids

(2010) Heidi Menrad et al.   HEPATOLOGY

Multicellular tumor spheroids: An underestimated tool is catching up again

(2010) Franziska Hirschhaeuser et al.   JOURNAL OF BIOTECHNOLOGY

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Immunohistochemical Expression of Stem Cell, Endothelial Cell, and Chemosensitivity Markers in Primary Glioma Spheroids Cultured in Serum-Containing and Serum-Free Medium

(2010) Karina Christensen et al.   NEUROSURGERY

Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1

(2010) Nuria Pescador et al.   PLoS One

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

 H2AX Expression in Tumors Exposed to Cisplatin and Fractionated Irradiation

(2009) C. A. Banuelos et al.   CLINICAL CANCER RESEARCH

Cell cycle and apoptotic effects of SAHA are regulated by the cellular microenvironment in HCT116 multicellular tumour spheroids

(2009) Valérie Lobjois et al.   EUROPEAN JOURNAL OF CANCER

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Histone H2AX is integral to hypoxia-driven neovascularization

(2009) Matina Economopoulou et al.   NATURE MEDICINE

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes

(2009) Fátima Pérez de Heredia et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Endogenous and radiation-induced expression of γH2AX in biopsies from patients treated for carcinoma of the uterine cervix

(2009) Peggy L. Olive et al.   RADIOTHERAPY AND ONCOLOGY

Chronic Hypoxia Decreases Synthesis of Homologous Recombination Proteins to Offset Chemoresistance and Radioresistance

(2008) N. Chan et al.   CANCER RESEARCH

Energy metabolism transition in multi-cellular human tumor spheroids

(2008) Sara Rodríguez-Enríquez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY

Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids

(2008) Hari R. Kumar et al.   PEDIATRIC SURGERY INTERNATIONAL