Hypoxia signaling in human diseases and therapeutic targets

Effects of cigarette smoke on pulmonary endothelial cells

(2018) Qing Lu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting Hypoxia-Inducible Factor-1α/Pyruvate Dehydrogenase Kinase 1 Axis by Dichloroacetate Suppresses Bleomycin-induced Pulmonary Fibrosis

(2018) Justin Goodwin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeting Hypoxia Signaling for Perioperative Organ Injury

(2018) Xiaoyi Yuan et al.   ANESTHESIA AND ANALGESIA

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Hypoxia–Adenosine Link during Intestinal Inflammation

(2018) Jessica L. Bowser et al.   JOURNAL OF IMMUNOLOGY

Deficiency of HIF-1α in myeloid cells protects E. coli or LPS-induced acute lung injury

(2018) Yuanyuan Huang et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury

(2018) Michael Koeppen et al.   Nature Communications

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation

(2018) Dorien Kiers et al.   EBioMedicine

HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis

(2017) Kemly Philip et al.   FASEB JOURNAL

The hypoxia-adenosine link during inflammation

(2017) Jessica L. Bowser et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure

(2017) Eunyoung Tak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

(2017) Omar A. Mesarwi et al.   PLoS One

Matrix Remodeling in Pulmonary Fibrosis and Emphysema

(2016) Tejaswini Kulkarni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

(2016) Eli M. Wallace et al.   CANCER RESEARCH

Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin

(2016) Navid M. Farsijani et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factors as molecular targets for liver diseases

(2016) Cynthia Ju et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

(2016) Bethany Baumann et al.   KIDNEY INTERNATIONAL

Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension

(2015) Harry Karmouty-Quintana et al.   FASEB JOURNAL

Hypoxia signaling during acute lung injury

(2015) Christine U. Vohwinkel et al.   JOURNAL OF APPLIED PHYSIOLOGY

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

(2015) Sandra Hoegl et al.   JOURNAL OF IMMUNOLOGY

Differential Tissue-Specific Function of Adora2b in Cardioprotection

(2015) Seong-wook Seo et al.   JOURNAL OF IMMUNOLOGY

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease

(2015) Peter Mirtschink et al.   NATURE

A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery

(2015) Patrick Meybohm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury

(2014) Pinelopi P. Kapitsinou et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

(2014) T. Eckle et al.   JOURNAL OF IMMUNOLOGY

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

Pathogenesis of liver cirrhosis

(2014) Wen-Ce Zhou   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of Hypoxia-induced Pulmonary Hypertension by Vascular Smooth Muscle Hypoxia-Inducible Factor-1α

(2013) Molly K. Ball et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Involvement of the HIF-1α and Wnt/β-catenin pathways in the protective effects of losartan on fatty liver graft with ischaemia/reperfusion injury

(2013) Ying-Ying Yang et al.   CLINICAL SCIENCE

Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease

(2013) Tingting Weng et al.   FASEB JOURNAL

Hypoxia and inflammation are two sides of the same coin

(2013) K. Bartels et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Unfavourable consequences of chronic cardiac HIF-1α stabilization

(2012) Marion Hölscher et al.   CARDIOVASCULAR RESEARCH

MicroRNA-199a-5p Is Associated With Hypoxia-Inducible Factor-1α Expression in Lungs From Patients With COPD

(2012) Shiro Mizuno et al.   CHEST

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

(2012) Jens M. Poth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Deficiency of the oxygen sensor PHD1 augments liver regeneration after partial hepatectomy

(2012) Martin Mollenhauer et al.   LANGENBECKS ARCHIVES OF SURGERY

Pretreatment with Mangafodipir Improves Liver Graft Tolerance to Ischemia/Reperfusion Injury in Rat

(2012) Ismail Ben Mosbah et al.   PLoS One

Hypoxia-Inducible Factor Activation Protects the Kidney from Gentamicin-Induced Acute Injury

(2012) Jeong-myung Ahn et al.   PLoS One

Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-  signaling

(2012) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute Acetaminophen Intoxication Leads to Hepatic Iron Loading by Decreased Hepcidin Synthesis

(2012) Rachel P. L. van Swelm et al.   TOXICOLOGICAL SCIENCES

Silencing of Hypoxia-Inducible Factor-1α Gene Attenuated Angiotensin II–Induced Renal Injury in Sprague-Dawley Rats

(2011) Qing Zhu et al.   HYPERTENSION

Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways

(2011) Hongmei Yu et al.   JOURNAL OF APPLIED TOXICOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation

(2010) A.-K. Riegel et al.   BLOOD

Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis

(2010) Bryan L. Copple et al.   LIVER INTERNATIONAL

Mechanism of Hypoxia-Induced NF- B

(2010) C. Culver et al.   MOLECULAR AND CELLULAR BIOLOGY

Conditional HIF-1α Expression Produces a Reversible Cardiomyopathy

(2010) Raffi Bekeredjian et al.   PLoS One

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

(2009) Jeon-OK Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1α

(2009) Huan-Xin Zhao et al.   BASIC RESEARCH IN CARDIOLOGY

Hypoxia Inducible Factor-2α Stabilization and Maxi-K + Channel β 1 -Subunit Gene Repression by Hypoxia in Cardiac Myocytes

(2009) Lucía Bautista et al.   CIRCULATION RESEARCH

Cigarette smoke extract reduces VEGF in primary human airway epithelial cells

(2009) J. V. Thaikoottathil et al.   EUROPEAN RESPIRATORY JOURNAL

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenosine A2A receptor is a unique angiogenic target of HIF-2  in pulmonary endothelial cells

(2009) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repetitive Hypoxic Preconditioning Attenuates Renal Ischemia/Reperfusion Induced Oxidative Injury via Upregulating HIF-1α–Dependent bcl-2 Signaling

(2009) Chih-Ching Yang et al.   TRANSPLANTATION

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion

(2008) Zhi Zhong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HIF Activation Protects From Acute Kidney Injury

(2008) A. Weidemann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics

(2008) Leon G. Fine et al.   KIDNEY INTERNATIONAL

Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice

(2008) Jeehee Kim et al.   LIVER TRANSPLANTATION