Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment

Functions of NKG2D in CD8+ T cells: an opportunity for immunotherapy

(2018) Kushal Prajapati et al.   Cellular & Molecular Immunology

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell–driven tumor immunity

(2018) Lucas Ferrari de Andrade et al.   SCIENCE

Personalized Cancer Medicine: An Organoid Approach

(2018) Hamidreza Aboulkheyr Es et al.   TRENDS IN BIOTECHNOLOGY

A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity

(2018) Hilary Sherman et al.   Frontiers in Immunology

Activated human primary NK cells efficiently kill colorectal cancer cells in 3D spheroid cultures irrespectively of the level of PD-L1 expression

(2018) Pilar M. Lanuza et al.   OncoImmunology

Cancer cells growing on perfused 3D collagen model produced higher reactive oxygen species level and were more resistant to cisplatin compared to the 2D model

(2018) Qingxi Liu et al.   Journal of Applied Biomaterials & Functional Materials

Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures

(2017) Sigrid S. Árnadóttir et al.   Molecular Oncology

Natural killer cell-mediated immunosurveillance of human cancer

(2017) Karl-Johan Malmberg et al.   SEMINARS IN IMMUNOLOGY

Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells

(2017) Renxiang Huang et al.   Oncology Letters

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

(2017) Jiehui Deng et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Unsuccessful mitosis in multicellular tumour spheroids

(2017) Annie Molla et al.   Oncotarget

Phenotype of NK-Like CD8(+) T Cells with Innate Features in Humans and Their Relevance in Cancer Diseases

(2017) Alice Barbarin et al.   Frontiers in Immunology

The influence of stromal cells and tumor-microenvironment-derived cytokines and chemokines on CD3+CD8+ tumor infiltrating lymphocyte subpopulations

(2017) Stefan Koeck et al.   OncoImmunology

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production

(2017) Cristina Capuano et al.   OncoImmunology

Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice

(2017) Janneke S. Hoogstad-van Evert et al.   OncoImmunology

Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine

(2017) Maria Jeppesen et al.   PLoS One

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

(2015) Ariane Giannattasio et al.   BMC CANCER

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

(2015) L. Ruggeri et al.   HAEMATOLOGICA

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

(2015) L. Ruggeri et al.   HAEMATOLOGICA

Cetuximab Reconstitutes Pro-Inflammatory Cytokine Secretions and Tumor-Infiltrating Capabilities of sMICA-Inhibited NK Cells in HNSCC Tumor Spheroids

(2015) Stephan Klöss et al.   Frontiers in Immunology

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Phenotypic analysis of T cells infiltrating colon cancers: Correlations with oncogenetic status

(2015) Mircea Chirica et al.   OncoImmunology

“In vitro” 3D models of tumor-immune system interaction

(2014) Christian Hirt et al.   ADVANCED DRUG DELIVERY REVIEWS

Clinical and immunological significance of HLA-E in stem cell transplantation and cancer

(2014) L. Wieten et al.   TISSUE ANTIGENS

T-Cell and NK-Cell Infiltration into Solid Tumors: A Key Limiting Factor for Efficacious Cancer Immunotherapy

(2014) I. Melero et al.   Cancer Discovery

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Possible association of decreased NKG2D expression levels and suppression of the activity of natural killer cells in patients with colorectal cancer

(2011) YAJUAN SHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

NKG2D Ligand Expression in Human Colorectal Cancer Reveals Associations with Prognosis and Evidence for Immunoediting

(2009) R. W. McGilvray et al.   CLINICAL CANCER RESEARCH

HLA-E and HLA-E-Bound Peptides: Recognition by Subsets of NK and T Cells

(2009) Gabriella Pietra et al.   CURRENT PHARMACEUTICAL DESIGN

A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration

(2009) Thomas K. Hoffmann et al.   INTERNATIONAL JOURNAL OF CANCER