3D models in the new era of immune oncology: focus on T cells, CAF and ECM

Design of spherically structured 3D in vitro tumor models -Advances and prospects

(2018) L.P. Ferreira et al.   Acta Biomaterialia

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)

(2018) T R Cottrell et al.   ANNALS OF ONCOLOGY

3D-3-culture: A tool to unveil macrophage plasticity in the tumour microenvironment

(2018) Sofia P. Rebelo et al.   BIOMATERIALS

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

Cancer-stimulated CAFs enhance monocyte differentiation and pro-tumoral TAM activation via IL-6 and GM-CSF secretion

(2018) Haaglim Cho et al.   CLINICAL CANCER RESEARCH

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

(2018) Minan Wang et al.   FASEB JOURNAL

Inhibiting YAP expression suppresses pancreatic cancer progression by disrupting tumor-stromal interactions

(2018) Zhengdong Jiang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions

(2018) Manami Sugimoto et al.   LAB ON A CHIP

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

(2018) Franck Pagès et al.   LANCET

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis

(2018) Francesca Di Modugno et al.   ONCOGENE

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

(2018) Yusheng Cheng et al.   Cell Death & Disease

Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation

(2018) Supriya Nagaraju et al.   Advanced Healthcare Materials

Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells

(2018) Zhenzhen Wang et al.   Advanced Science

Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

(2018) Linda Ziani et al.   Frontiers in Immunology

Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy

(2018) Yiliang Li et al.   Frontiers in Immunology

Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma

(2018) Iftikhar Ali Khawar et al.   NEOPLASIA

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

(2018) Spencer C. Wei et al.   Cancer Discovery

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

(2018) Ana S. Nunes et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Evolution of Metastases in Space and Time under Immune Selection

(2018) Mihaela Angelova et al.   CELL

Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy

(2018) Priyamvada Jayaprakash et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse Models for Cancer Immunotherapy Research

(2018) Brian Olson et al.   Cancer Discovery

Tumor-like lung cancer model based on 3D bioprinting

(2018) Xiong Wang et al.   3 Biotech

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

(2017) Stephen Riffle et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

The emergence of optical elastography in biomedicine

(2017) Brendan F. Kennedy et al.   Nature Photonics

Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease

(2017) Penney M. Gilbert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

(2017) Jiehui Deng et al.   Cancer Discovery

Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers

(2017) Oliver M.T. Pearce et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems

(2017) Yuan Tang et al.   Scientific Reports

Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their Bioengineering

(2017) Genyuan Zhu et al.   Frontiers in Immunology

3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells

(2017) Stefania Parlato et al.   Scientific Reports

3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study

(2016) Xuan Zhou et al.   ACS Applied Materials & Interfaces

A comprehensive review on droplet-based bioprinting: Past, present and future

(2016) Hemanth Gudapati et al.   BIOMATERIALS

Current advances and future perspectives in extrusion-based bioprinting

(2016) Ibrahim T. Ozbolat et al.   BIOMATERIALS

A novel three-dimensional heterotypic spheroid model for the assessment of the activity of cancer immunotherapy agents

(2016) Sylvia Herter et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Fibroblast activation in cancer: when seed fertilizes soil

(2016) Sanya-Eduarda Kuzet et al.   CELL AND TISSUE RESEARCH

Single cell analysis of human tissues and solid tumors with mass cytometry

(2016) Nalin Leelatian et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture

(2016) Shantanu Pradhan et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Trends and advances in tumor immunology and lung cancer immunotherapy

(2016) Mohanad Aldarouish et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chemotaxis-driven assembly of endothelial barrier in a tumor-on-a-chip platform

(2016) Aereas Aung et al.   LAB ON A CHIP

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma

(2016) S Murakami et al.   ONCOGENE

Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial–Mesenchymal Transition

(2016) Spencer C. Wei et al.   TRENDS IN CELL BIOLOGY

Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment

(2016) Silvio Däster et al.   Oncotarget

Design and Printing Strategies in 3D Bioprinting of Cell-Hydrogels: A Review

(2016) Jia Min Lee et al.   Advanced Healthcare Materials

Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy

(2016) Rikke B. Holmgaard et al.   OncoImmunology

Computer-aided multiple-head 3D printing system for printing of heterogeneous organ/tissue constructs

(2016) Jin Woo Jung et al.   Scientific Reports

Biomechanics of subcellular structures by non-invasive Brillouin microscopy

(2016) Giuseppe Antonacci et al.   Scientific Reports

Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids

(2016) Yeonhwa Song et al.   Scientific Reports

Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

(2015) Cristina Colosi et al.   ADVANCED MATERIALS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

Recent developments in multiplexing techniques for immunohistochemistry

(2015) Angela R Dixon et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma

(2015) Gaixia He et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma

(2015) Giuseppe Antonacci et al.   Journal of the Royal Society Interface

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy

(2015) Giuliano Scarcelli et al.   NATURE METHODS

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Notes on stochastic (bio)-logic gates: computing with allosteric cooperativity

(2015) Elena Agliari et al.   Scientific Reports

Real-Time Imaging of Resident T Cells in Human Lung and Ovarian Carcinomas Reveals How Different Tumor Microenvironments Control T Lymphocyte Migration

(2015) Houcine Bougherara et al.   Frontiers in Immunology

Cell encapsulation via microtechnologies

(2014) AhRan Kang et al.   BIOMATERIALS

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Matrigel supports neural, melanocytic and chondrogenic differentiation of trunk neural crest cells

(2014) Ana B. Ramos-Hryb et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Feeder-Free Culture System for Expansion of Mouse Spermatogonial Stem Cells

(2014) Na Young Choi et al.   MOLECULES AND CELLS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Localization, Invasion, and Turnover Are Differently Influenced by Healthy and Tumor-Derived Extracellular Matrix

(2014) Luca Genovese et al.   TISSUE ENGINEERING PART A

Tertiary lymphoid structures in cancer and beyond

(2014) Marie-Caroline Dieu-Nosjean et al.   TRENDS IN IMMUNOLOGY

Three-dimensional printing of Hela cells for cervical tumor modelin vitro

(2014) Yu Zhao et al.   Biofabrication

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance

(2014) D. T. Fearon   Cancer Immunology Research

Spectral broadening in Brillouin imaging

(2013) Giuseppe Antonacci et al.   APPLIED PHYSICS LETTERS

Three-Dimensional Scaffolds to Evaluate Tumor Associated Fibroblast-Mediated Suppression of Breast Tumor Specific T Cells

(2013) Vy Phan-Lai et al.   BIOMACROMOLECULES

3D printing of biomimetic microstructures for cancer cell migration

(2013) Tina Qing Huang et al.   BIOMEDICAL MICRODEVICES

Immune-suppressive properties of the tumor microenvironment

(2013) Jürgen C. Becker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

DNA nanospheres with microfluidics: a promising platform for cancer diagnosis?

(2013) Z Hugh Fan et al.   Nanomedicine

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

In Vitro Model of Tumor Cell Extravasation

(2013) Jessie S. Jeon et al.   PLoS One

Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules

(2013) I. Rizvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Microenvironment and Strategies to Improve Drug Distribution

(2013) Jasdeep K. Saggar et al.   Frontiers in Oncology

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-Intrinsic Abrogation of TGF-  Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer

(2012) C. K. Chou et al.   JOURNAL OF IMMUNOLOGY

A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime

(2012) Qian Zhang et al.   LAB ON A CHIP

Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment

(2012) Luca Businaro et al.   LAB ON A CHIP

CD73: a potent suppressor of antitumor immune responses

(2012) Paul. A. Beavis et al.   TRENDS IN IMMUNOLOGY

3D Porous Chitosan-Alginate Scaffolds: A New Matrix for Studying Prostate Cancer Cell-Lymphocyte Interactions In Vitro

(2012) Stephen J. Florczyk et al.   Advanced Healthcare Materials

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro

(2010) Valerie L. Cross et al.   BIOMATERIALS

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Multiple uses of basement membrane-like matrix (BME/Matrigel) in vitro and in vivo with cancer cells

(2010) Gabriel Benton et al.   INTERNATIONAL JOURNAL OF CANCER

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

(2010) V. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Laser-based direct-write techniques for cell printing

(2010) Nathan R Schiele et al.   Biofabrication

Particle-Tracking Microrheology of Living Cells: Principles and Applications

(2009) Denis Wirtz   Annual Review of Biophysics

Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

(2009) Amy Y. Hsiao et al.   BIOMATERIALS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Optical tweezers for single cells

(2008) H. Zhang et al.   Journal of the Royal Society Interface