Three‐dimensional cryogel matrix for spheroid formation and anti‐cancer drug screening

Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency

(2019) Mengxiang Zhu et al.   Scientific Reports

Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

(2018) Jessica Hoarau-Véchot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Hydrogel microenvironments for cancer spheroid growth and drug screening

(2018) Yunfeng Li et al.   Science Advances

Efficient in situ gene delivery via PEG diacrylate matrices

(2018) Paresh Shrimali et al.   Biomaterials Science

Advances in multicellular spheroids formation

(2017) X. Cui et al.   Journal of the Royal Society Interface

Breast tissue stiffness estimation for surgical guidance using gravity-induced excitation

(2017) Rebekah H Griesenauer et al.   PHYSICS IN MEDICINE AND BIOLOGY

Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence

(2017) Natasha S Lewis et al.   Journal of Tissue Engineering

Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment

(2017) Daniel S. Reynolds et al.   Scientific Reports

Gelatin Methacrylate Hydrogels as Biomimetic Three-Dimensional Matrixes for Modeling Breast Cancer Invasion and Chemoresponse in Vitro

(2016) Anuradha D. Arya et al.   ACS Applied Materials & Interfaces

Thermo-responsive polymer aided spheroid culture in cryogel based platform for high throughput drug screening

(2016) J. Sarkar et al.   ANALYST

Transparent Porous Polysaccharide Cryogels Provide Biochemically Defined, Biomimetic Matrices for Tunable 3D Cell Culture

(2016) Roger Y. Tam et al.   CHEMISTRY OF MATERIALS

Preclinical screening methods in cancer

(2016) RameshBabu Bodla et al.   INDIAN JOURNAL OF PHARMACOLOGY

Generation of Multicellular Breast Cancer Tumor Spheroids: Comparison of Different Protocols

(2016) Karolin Froehlich et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Superporous Poly(ethylene glycol) Diacrylate Cryogel with a Defined Elastic Modulus for Prostate Cancer Cell Research

(2016) Bettina Göppert et al.   Small

Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity

(2016) Shreya Raghavan et al.   Oncotarget

Impact of adjustable cryogel properties on the performance of prostate cancer cells in 3D

(2016) A. Bäcker et al.   SpringerPlus

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

Combined Effect of Cryogel Matrix and Temperature-Reversible Soluble–Insoluble Polymer for the Development of in Vitro Human Liver Tissue

(2015) Jyoti Kumari et al.   ACS Applied Materials & Interfaces

Efficacy of supermacroporous poly(ethylene glycol)–gelatin cryogel matrix for soft tissue engineering applications

(2015) Archana Sharma et al.   Materials Science & Engineering C-Materials for Biological Applications

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Modulation of Huh7.5 Spheroid Formation and Functionality Using Modified PEG-Based Hydrogels of Different Stiffness

(2015) Bae Hoon Lee et al.   PLoS One

Generation of Multicellular Tumor Spheroids with Microwell-Based Agarose Scaffolds for Drug Testing

(2015) Xue Gong et al.   PLoS One

Gelatine methacrylamide-based hydrogels: An alternative three-dimensional cancer cell culture system

(2014) Elke Kaemmerer et al.   Acta Biomaterialia

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Advances in 3D cell culture technologies enabling tissue-like structures to be createdin vitro

(2014) Eleanor Knight et al.   JOURNAL OF ANATOMY

Embedded multicellular spheroids as a biomimetic 3D cancer model for evaluating drug and drug-device combinations

(2013) Kristie M. Charoen et al.   BIOMATERIALS

Cryogels for biomedical applications

(2013) Timothy M. A. Henderson et al.   Journal of Materials Chemistry B

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle

(2012) Francisca Molina-Jimenez et al.   VIROLOGY

Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens

(2011) Hoa H. Truong et al.   BIOMATERIALS

The liquid overlay technique is the key to formation of co-culture spheroids consisting of primary osteoblasts, fibroblasts and endothelial cells

(2011) Wolfgang Metzger et al.   CYTOTHERAPY

Porous structure and water state in cross-linked polymer and protein cryo-hydrogels

(2011) Irina N. Savina et al.   Soft Matter

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern

(2010) Özlem Darcansoy Işeri et al.   BIOMEDICINE & PHARMACOTHERAPY

Taxanes Alone or in Combination With Anthracyclines As First-Line Therapy of Patients With Metastatic Breast Cancer

(2008) Martine J. Piccart-Gebhart et al.   JOURNAL OF CLINICAL ONCOLOGY