The role of the myofibroblast in tumor stroma remodeling

The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms

(2013) T Velnar et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Recent Developments in Myofibroblast Biology

(2012) Boris Hinz et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin αvβ6-dependent physical force

(2012) Marilyn M. Giacomini et al.   EXPERIMENTAL CELL RESEARCH

A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and epithelial-mesenchymal transition

(2012) Jae Yeon Seok et al.   HEPATOLOGY

LTBPs, more than just an escort service

(2012) Vesna Todorovic et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms

(2012) Mariya T. Sweetwyne et al.   MATRIX BIOLOGY

Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma

(2012) Shannon Kidd et al.   PLoS One

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis

(2011) Harold A. Chapman   Annual Review of Physiology

Myofibroblast-Mediated Adventitial Remodeling

(2011) Matteo Coen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Liver fibrogenic cells

(2011) Stuart J. Forbes et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

(2011) Paolo Cirri et al.   CANCER AND METASTASIS REVIEWS

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

(2011) H. E. Barker et al.   CANCER RESEARCH

Tumor stroma reaction-related gene signature predicts clinical outcome in human hepatocellular carcinoma

(2011) Qiang Gao et al.   CANCER SCIENCE

Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

(2011) Eric Festa et al.   CELL

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals

(2011) Toru Maeda et al.   CURRENT BIOLOGY

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

The functional role of reactive stroma in benign prostatic hyperplasia

(2011) Isaiah G. Schauer et al.   DIFFERENTIATION

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Perivascular localization of dermal stem cells in human scalp

(2011) Haruyo Yamanishi et al.   EXPERIMENTAL DERMATOLOGY

Exploring anti-TGF-β therapies in cancer and fibrosis

(2011) Lukas J. A. C. Hawinkels et al.   GROWTH FACTORS

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

(2011) Andrew S. Chu et al.   HEPATOLOGY

Extracellular matrix remodelling properties of human fibrocytes

(2011) Lorenza Bianchetti et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Epithelial–mesenchymal transition in chronic liver disease: Fibrogenesis or escape from death?

(2011) Massimo Pinzani   JOURNAL OF HEPATOLOGY

Interstitial guidance of cancer invasion

(2011) Pavlo G. Gritsenko et al.   JOURNAL OF PATHOLOGY

Tumor microenvironment and progression

(2011) Harold F. Dvorak et al.   JOURNAL OF SURGICAL ONCOLOGY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Periostin, a matrix protein, has potential as a novel serodiagnostic marker for cholangiocarcinoma

(2011) Fujimoto   ONCOLOGY REPORTS

Leukocyte composition of human breast cancer

(2011) B. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative origins of stroma in normal organs and disease

(2011) Mikhail G. Kolonin et al.   Stem Cell Research

Mechanisms of pathological scarring: Role of myofibroblasts and current developments

(2011) Vincent Sarrazy et al.   WOUND REPAIR AND REGENERATION

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

An Essential Role for Resident Fibroblasts in Experimental Lung Fibrosis Is Defined by Lineage-Specific Deletion of High-Affinity Type II Transforming Growth Factor β Receptor

(2010) Rachel K. Hoyles et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cell Motility and Mechanics in Three-Dimensional Collagen Matrices

(2010) Frederick Grinnell et al.   Annual Review of Cell and Developmental Biology

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Fibrogenic Reactions in Lung Disease

(2010) Jun Araya et al.   Annual Review of Pathology-Mechanisms of Disease

Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation

(2010) J. Webber et al.   CANCER RESEARCH

On the origin of cancer-associated fibroblasts

(2010) Charlotte Anderberg et al.   CELL CYCLE

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Dead or Alive?

(2010) Yury Popov et al.   GASTROENTEROLOGY

Thy-1-Integrin αvβ5Interactions Inhibit Lung Fibroblast Contraction-induced Latent Transforming Growth Factor-β1 Activation and Myofibroblast Differentiation

(2010) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

(2010) A. Buxboim et al.   JOURNAL OF CELL SCIENCE

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Factors Affecting Wound Healing

(2010) S. Guo et al.   JOURNAL OF DENTAL RESEARCH

The dynamic roles of TGF-β in cancer

(2010) Erik Meulmeester et al.   JOURNAL OF PATHOLOGY

Fibrogenic cell phenotype modifications during remodelling of normal and pathological human liver in cultured slices

(2010) Christelle Guyot et al.   LIVER INTERNATIONAL

Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

(2010) Kusumawadee Utispan et al.   Molecular Cancer

Evolving challenges in hepatic fibrosis

(2010) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

(2010) A N Santhanam et al.   ONCOGENE

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Platelet-derived microparticles – an updated perspective

(2010) Pia R.M. Siljander   THROMBOSIS RESEARCH

TGFβ: a sleeping giant awoken by integrins

(2010) John J. Worthington et al.   TRENDS IN BIOCHEMICAL SCIENCES

Forcing form and function: biomechanical regulation of tumor evolution

(2010) Hongmei Yu et al.   TRENDS IN CELL BIOLOGY

Integrin-Mediated Transforming Growth Factor-β Activation, a Potential Therapeutic Target in Fibrogenic Disorders

(2009) Stephen L. Nishimura   AMERICAN JOURNAL OF PATHOLOGY

Endothelial–Mesenchymal Transition as a Novel Mechanism for Generating Myofibroblasts during Diabetic Nephropathy

(2009) Akane Kizu et al.   AMERICAN JOURNAL OF PATHOLOGY

Emerging Concepts in the Pathogenesis of Lung Fibrosis

(2009) William D. Hardie et al.   AMERICAN JOURNAL OF PATHOLOGY

Pathological roles of bone marrow-derived stellate cells in a mouse model of alcohol-induced fatty liver

(2009) Tatsuya Fujimiya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis

(2009) Antje Moeller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Mesenchymal Stem Cells: Flip Side of the Coin

(2009) Pravin J. Mishra et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Cell-Cycle Control by Physiological Matrix Elasticity and In Vivo Tissue Stiffening

(2009) Eric A. Klein et al.   CURRENT BIOLOGY

Multipotent skin-derived precursors: from biology to clinical translation

(2009) David P.J. Hunt et al.   CURRENT OPINION IN BIOTECHNOLOGY

Extracellular microfibrils: contextual platforms for TGFβ and BMP signaling

(2009) Francesco Ramirez et al.   CURRENT OPINION IN CELL BIOLOGY

Tightening the Connections between Cadherins and Fibronectin Matrix

(2009) Geoffrey C. Hunt et al.   DEVELOPMENTAL CELL

TGF-ß signaling, tumor microenvironment and tumor progression: the butterfly effect

(2009) Amit Joshi   Frontiers in Bioscience-Landmark

Negligible Contribution of Bone Marrow-Derived Cells to Collagen Production During Hepatic Fibrogenesis in Mice

(2009) Reiichi Higashiyama et al.   GASTROENTEROLOGY

Scar and Contracture: Biological Principles

(2009) Peter Kwan et al.   HAND CLINICS

Portal fibroblasts: Underappreciated mediators of biliary fibrosis

(2009) Jonathan A. Dranoff et al.   HEPATOLOGY

The role of stem cells in liver repair and fibrosis

(2009) Linda E. Greenbaum et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hyaluronan Orchestrates Transforming Growth Factor-β1-dependent Maintenance of Myofibroblast Phenotype

(2009) Jason Webber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The myofibroblast: Paradigm for a mechanically active cell

(2009) Boris Hinz   JOURNAL OF BIOMECHANICS

Wound repair at a glance

(2009) T. J. Shaw et al.   JOURNAL OF CELL SCIENCE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Matrix-Degrading Metalloproteinases in Photoaging

(2009) Taihao Quan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Myocardial remodeling after infarction: the role of myofibroblasts

(2009) Susanne W. M. van den Borne et al.   Nature Reviews Cardiology

Transforming growth factor β as a therapeutic target in systemic sclerosis

(2009) John Varga et al.   Nature Reviews Rheumatology

Cardiac fibroblasts: At the heart of myocardial remodeling

(2009) Karen E. Porter et al.   PHARMACOLOGY & THERAPEUTICS

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Interactions between extracellular matrix and growth factors in wound healing

(2009) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

The hard life of soft cells

(2009) Paul A. Janmey et al.   CELL MOTILITY AND THE CYTOSKELETON

The Role of a Human Hematopoietic Mesenchymal Progenitor in Wound Healing and Fibrotic Diseases and Implications for Therapy

(2009) Sabrina Mattoli et al.   Current Stem Cell Research & Therapy

Tissue stiffness, latent TGF-β1 Activation, and mechanical signal transduction: Implications for the pathogenesis and treatment of fibrosis

(2009) Boris Hinz   Current Rheumatology Reports

What the Lung Has Taught Us about Latent TGF-β Activation

(2008) Poshala Aluwihare et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Looking Older

(2008) Gary J. Fisher et al.   ARCHIVES OF DERMATOLOGY

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor- 1

(2008) J. Ahamed et al.   BLOOD

The role of endothelial-to-mesenchymal transition in cancer progression

(2008) S Potenta et al.   BRITISH JOURNAL OF CANCER

Mechanical tension stimulates the transdifferentiation of fibroblasts into myofibroblasts in human burn scars

(2008) Johan P.E. Junker et al.   BURNS

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Transforming Growth Factor  : Tumor Suppressor or Promoter? Are Host Immune Cells the Answer?

(2008) L. Yang et al.   CANCER RESEARCH

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Assessment and nutritional aspects of wound healing

(2008) Antonio CL Campos et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Regulation of Prostatic Stem Cells by Stromal Niche in Health and Disease

(2008) Gail P. Risbridger et al.   ENDOCRINOLOGY

Integrins and the activation of latent transforming growth factor β1 – An intimate relationship

(2008) P WIPFF et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Transient elastography for liver fibrosis diagnosis

(2008) Ellen Sloth Andersen et al.   European Journal of Internal Medicine

The role of proteases in transforming growth factor-β activation

(2008) G JENKINS   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis

(2008) Annika Andersson-Sjöland et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells

(2008) Atsushi Kanno et al.   INTERNATIONAL JOURNAL OF CANCER

Stromal myofibroblasts are drivers of invasive cancer growth

(2008) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF CANCER

Why are MSCs therapeutic? New data: new insight

(2008) AI Caplan   JOURNAL OF PATHOLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bone Marrow-Derived Human Mesenchymal Stem Cells Become Quiescent on Soft Substrates but Remain Responsive to Chemical or Mechanical Stimuli

(2008) Jessamine P. Winer et al.   TISSUE ENGINEERING PART A

Growth control by intracellular tension and extracellular stiffness

(2008) Richard K. Assoian et al.   TRENDS IN CELL BIOLOGY

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

(2008) Stephan Barrientos et al.   WOUND REPAIR AND REGENERATION

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Multipotent skin-derived precursors: adult neural crest-related precursors with therapeutic potential

(2007) K. J.L Fernandes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES