Adaptive Changes of Glioblastoma Cells Following Exposure to Hypoxic (1% Oxygen) Tumour Microenvironment

A novel 3D in vitro model of glioblastoma reveals resistance to temozolomide which was potentiated by hypoxia

(2019) Ahmed Musah-Eroje et al.   JOURNAL OF NEURO-ONCOLOGY

Reciprocal Signaling between Glioblastoma Stem Cells and Differentiated Tumor Cells Promotes Malignant Progression

(2018) Xiuxing Wang et al.   Cell Stem Cell

A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells

(2018) Eroje M. Ahmed et al.   CELLULAR ONCOLOGY

Radiogenomic analysis of hypoxia pathway is predictive of overall survival in Glioblastoma

(2018) Niha Beig et al.   Scientific Reports

Role of Hypoxic Stress in Regulating Tumor Immunogenicity, Resistance and Plasticity

(2018) Stéphane Terry et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway

(2017) Jingping Zhu et al.   Scientific Reports

The Role of Hypoxia in Glioblastoma Invasion

(2017) Ana Monteiro et al.   Cells

Cell cycle progression in glioblastoma cells is unaffected by pathophysiological levels of hypoxia

(2016) Rosalie Richards et al.   PeerJ

Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis

(2015) Justin V. Joseph et al.   CANCER LETTERS

Variation over time and interdependence between disease progression and death among patients with glioblastoma on RTOG 0525

(2015) Meihua Wang et al.   NEURO-ONCOLOGY

The role of ion channels in the hypoxia-induced aggressiveness of glioblastoma

(2015) Luigi Sforna et al.   Frontiers in Cellular Neuroscience

Correlation between 18F-fluoromisonidazole PET and expression of HIF-1α and VEGF in newly diagnosed and recurrent malignant gliomas

(2014) Nobuyuki Kawai et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma

(2014) Mingjun Guo et al.   PLoS One

Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia

(2014) Ryon H. Clarke et al.   PLoS One

Hypoxia Enhances Stemness of Cancer Stem Cells in Glioblastoma: An In Vitro Study

(2013) Pengcheng Li et al.   International Journal of Medical Sciences

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

(2013) Mark R. Gilbert et al.   JOURNAL OF CLINICAL ONCOLOGY

Hypoxia Modulates Fibroblastic Architecture, Adhesion and Migration: A Role for HIF-1α in Cofilin Regulation and Cytoplasmic Actin Distribution

(2013) Melanie Vogler et al.   PLoS One

Effect of hypoxia on generation of neurospheres from adipose tissue-derived canine mesenchymal stromal cells

(2013) D.J. Chung et al.   VETERINARY JOURNAL

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells

(2011) Yunfei Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Induces Tumor Aggressiveness and the Expansion of CD133-Positive Cells in a Hypoxia-Inducible Factor-1α-Dependent Manner in Pancreatic Cancer Cells

(2011) Okito Hashimoto et al.   PATHOBIOLOGY

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

(2011) Christian Frezza et al.   PLoS One

Glioblastoma Heterogeneity and More Accurate Representation in Research Models

(2011) Hugo Guerrero-Cázares et al.   World Neurosurgery

Hypoxia Increases the Expression of Stem-Cell Markers and Promotes Clonogenicity in Glioblastoma Neurospheres

(2010) Eli E. Bar et al.   AMERICAN JOURNAL OF PATHOLOGY

Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

(2010) Christina Holzwarth et al.   BMC CELL BIOLOGY

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

(2010) Sascha Seidel et al.   BRAIN

Environmental restrictions within tumor ecosystems select for a convergent, hypoxia-resistant phenotype of cancer stem cells

(2010) Massimo Olivotto et al.   CELL CYCLE

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells

(2010) Guido Santilli et al.   PLoS One

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

(2009) Yoshinori Yoshida et al.   Cell Stem Cell

Hypoxia Helps Glioma to Fight Therapy

(2009) Verena Amberger-Murphy   CURRENT CANCER DRUG TARGETS

Hypoxia or in situ normoxia: The stem cell paradigm

(2009) Zoran Ivanovic   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

(2009) S G M Piccirillo et al.   ONCOGENE

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Regional Hypoxia in Glioblastoma Multiforme Quantified with [18F]Fluoromisonidazole Positron Emission Tomography before Radiotherapy: Correlation with Time to Progression and Survival

(2008) A. M. Spence et al.   CLINICAL CANCER RESEARCH

CD133 Is a Marker of Bioenergetic Stress in Human Glioma

(2008) Corinne E. Griguer et al.   PLoS One