Bioengineered microenvironment to culture early embryos

Derivation of Mouse Haploid Trophoblast Stem Cells

(2019) Tongtong Cui et al.   Cell Reports

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis

(2019) Priscila Ramos-Ibeas et al.   Nature Communications

Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

(2019) Shaopeng Zhang et al.   Nature Communications

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

(2019) Stefano Vianello et al.   DEVELOPMENTAL CELL

Grow with the Flow: When Morphogenesis Meets Microfluidics

(2019) Pinak Samal et al.   ADVANCED MATERIALS

Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells

(2019) Mio Nakanishi et al.   CELL

Molecular recording of mammalian embryogenesis

(2019) Michelle M. Chan et al.   NATURE

Hydraulic control of mammalian embryo size and cell fate

(2019) Chii Jou Chan et al.   NATURE

Noninvasive preimplantation genetic testing for aneuploidy in spent medium may be more reliable than trophectoderm biopsy

(2019) Lei Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resetting histone modifications during human parental-to-zygotic transition

(2019) Weikun Xia et al.   SCIENCE

Organoids by design

(2019) Takanori Takebe et al.   SCIENCE

Self-organization of stem cells into embryos: A window on early mammalian development

(2019) Marta N. Shahbazi et al.   SCIENCE

Molecular architecture of lineage allocation and tissue organization in early mouse embryo

(2019) Guangdun Peng et al.   NATURE

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Engineered materials for organoid systems

(2019) Michael J. Kratochvil et al.   Nature Reviews Materials

Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

(2019) Ronghui Li et al.   CELL

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

(2019) Neophytos Christodoulou et al.   Nature Communications

Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution

(2018) Lei Gao et al.   CELL

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Deconstructing and reconstructing the mouse and human early embryo

(2018) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

(2018) Xufeng Xue et al.   NATURE MATERIALS

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

(2018) Melanie A. Eckersley-Maslin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exploring early human embryo development

(2018) Janet Rossant et al.   SCIENCE

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

(2018) Sophie M Morgani et al.   eLife

Extracellular matrix-based materials for regenerative medicine

(2018) George S. Hussey et al.   Nature Reviews Materials

3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate

(2018) Yufei Ma et al.   ADVANCED MATERIALS

A Multi-Sensor System for Measuring Bovine Embryo Metabolism

(2018) Yusra Obeidat et al.   BIOSENSORS & BIOELECTRONICS

Gene editing in human development: ethical concerns and practical applications

(2018) Janet Rossant   DEVELOPMENT

Geometrical confinement controls the asymmetric patterning of brachyury in cultures of pluripotent cells

(2018) Guillaume Blin et al.   DEVELOPMENT

Self-organization of a human organizer by combined Wnt and Nodal signalling

(2018) I. Martyn et al.   NATURE

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development

(2018) Thorsten Boroviak et al.   DEVELOPMENT

Opening the black box: Stem cell–based modeling of human post-implantation development

(2018) Kenichiro Taniguchi et al.   JOURNAL OF CELL BIOLOGY

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Trophoblast organoids as a model for maternal–fetal interactions during human placentation

(2018) Margherita Y. Turco et al.   NATURE

Debate ethics of embryo models from stem cells

(2018) Nicolas Rivron et al.   NATURE

Sequential formation and resolution of multiple rosettes drive embryo remodelling after implantation

(2018) Neophytos Christodoulou et al.   NATURE CELL BIOLOGY

Material approaches to active tissue mechanics

(2018) Wang Xi et al.   Nature Reviews Materials

Mosaicism between trophectoderm and inner cell mass

(2017) Antonio Capalbo et al.   FERTILITY AND STERILITY

Mechanical perspectives on the anterior-posterior axis polarization of mouse implanted embryos

(2017) Isao Matsuo et al.   MECHANISMS OF DEVELOPMENT

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Establishment of mouse expanded potential stem cells

(2017) Jian Yang et al.   NATURE

Genome editing reveals a role for OCT4 in human embryogenesis

(2017) Norah M. E. Fogarty et al.   NATURE

Revisiting the Warnock rule

(2017) J Benjamin Hurlbut et al.   NATURE BIOTECHNOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vitro culture of individual mouse preimplantation embryos: the role of embryo density, microwells, oxygen, timing and conditioned media

(2017) Rebecca L. Kelley et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

(2017) Daosheng Huang et al.   Scientific Reports

Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells

(2016) Xin Li et al.   CELL

Lineage specification in the mouse preimplantation embryo

(2016) Claire Chazaud et al.   DEVELOPMENT

Development-on-chip:in vitroneural tube patterning with a microfluidic device

(2016) Christopher J. Demers et al.   DEVELOPMENT

Oviduct: roles in fertilization and early embryo development

(2016) Shuai Li et al.   JOURNAL OF ENDOCRINOLOGY

Simultaneous monitoring of oxygen consumption and acidification rates of a single zebrafish embryo during embryonic development within a microfluidic device

(2016) Shih-Hao Huang et al.   Microfluidics and Nanofluidics

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Womb-on-a-chip biomimetic system for improved embryo culture and development

(2016) Kuo-Wei Chang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization

(2016) Livia Z. Yanez et al.   Nature Communications

Microwells support high-resolution time-lapse imaging and development of preimplanted mouse embryos

(2015) Yu-Hsiang Chung et al.   Biomicrofluidics

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq

(2015) P. Blakeley et al.   DEVELOPMENT

Pulsatile cell-autonomous contractility drives compaction in the mouse embryo

(2015) Jean-Léon Maître et al.   NATURE CELL BIOLOGY

Nanomaterials for Engineering Stem Cell Responses

(2015) Punyavee Kerativitayanan et al.   Advanced Healthcare Materials

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Three-dimensional nano-biointerface as a new platform for guiding cell fate

(2014) Xueli Liu et al.   CHEMICAL SOCIETY REVIEWS

Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst

(2014) G. C. Le Bin et al.   DEVELOPMENT

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Materials for stem cell factories of the future

(2014) Adam D. Celiz et al.   NATURE MATERIALS

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

(2014) Matthew J. Dalby et al.   NATURE MATERIALS

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

In vitro culture of mouse blastocysts beyond the implantation stages

(2014) Ivan Bedzhov et al.   Nature Protocols

Chondrogenic Differentiation of Adipose-Derived Stromal Cells in Combinatorial Hydrogels Containing Cartilage Matrix Proteins with Decoupled Mechanical Stiffness

(2014) Tianyi Wang et al.   TISSUE ENGINEERING PART A

Generation of organized germ layers from a single mouse embryonic stem cell

(2014) Yeh-Chuin Poh et al.   Nature Communications

3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells

(2014) Andrea Meinhardt et al.   Stem Cell Reports

External Mechanical Cues Trigger the Establishment of the Anterior-Posterior Axis in Early Mouse Embryos

(2013) Ryuji Hiramatsu et al.   DEVELOPMENTAL CELL

Extracellular Matrix-Mediated Differentiation of Human Embryonic Stem Cells: Differentiation to Insulin-Secreting Beta Cells

(2013) Karthikeyan Narayanan et al.   TISSUE ENGINEERING PART A

Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem Cells

(2012) Weiqiang Chen et al.   ACS Nano

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Human pre-implantation embryo development

(2012) K. K. Niakan et al.   DEVELOPMENT

Matrix nanotopography as a regulator of cell function

(2012) Deok-Ho Kim et al.   JOURNAL OF CELL BIOLOGY

Effect of Substrate Stiffness on Early Mouse Embryo Development

(2012) Kevin S. Kolahi et al.   PLoS One

Dynamics of anterior–posterior axis formation in the developing mouse embryo

(2012) Samantha A. Morris et al.   Nature Communications

Rethinking In Vitro Embryo Culture: New Developments in Culture Platforms and Potential to Improve Assisted Reproductive Technologies1

(2011) Gary D. Smith et al.   BIOLOGY OF REPRODUCTION

Self-Organization Phenomena in Embryonic Stem Cell-Derived Embryoid Bodies: Axis Formation and Breaking of Symmetry during Cardiomyogenesis

(2011) Christiane Fuchs et al.   CELLS TISSUES ORGANS

Derivation of haploid embryonic stem cells from mouse embryos

(2011) Martin Leeb et al.   NATURE

Simulating the Mammalian Blastocyst - Molecular and Mechanical Interactions Pattern the Embryo

(2011) Pawel Krupinski et al.   PLoS Computational Biology

Mechanical Stress as a Regulator of Cytoskeletal Contractility and Nuclear Shape in Embryonic Epithelia

(2010) Benjamen A. Filas et al.   ANNALS OF BIOMEDICAL ENGINEERING

Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

(2009) Yusuke Marikawa et al.   GENESIS

Noninvasive Metabolic Profiling Using Microfluidics for Analysis of Single Preimplantation Embryos

(2008) John Paul Urbanski et al.   ANALYTICAL CHEMISTRY

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Dynamic tensile properties of human placenta

(2008) Sarah J. Manoogian et al.   JOURNAL OF BIOMECHANICS