Deconstructing and reconstructing the mouse and human early embryo

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast

(2018) Giuliano G. Stirparo et al.   DEVELOPMENT

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

(2018) Sophie M Morgani et al.   eLife

Self-organization of a human organizer by combined Wnt and Nodal signalling

(2018) I. Martyn et al.   NATURE

Principles of early human development and germ cell program from conserved model systems

(2017) Toshihiro Kobayashi et al.   NATURE

Correction of a pathogenic gene mutation in human embryos

(2017) Hong Ma et al.   NATURE

Genome editing reveals a role for OCT4 in human embryogenesis

(2017) Norah M. E. Fogarty et al.   NATURE

Single-cell DNA methylome sequencing of human preimplantation embryos

(2017) Ping Zhu et al.   NATURE GENETICS

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation

(2017) Hisham Mohammed et al.   Cell Reports

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause

(2016) Roberta Scognamiglio et al.   CELL

Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo

(2016) Melanie D. White et al.   CELL

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos

(2016) Sophie Petropoulos et al.   CELL

Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos

(2016) Mubeen Goolam et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Human-Mouse Chimerism Validates Human Stem Cell Pluripotency

(2016) Victoria L. Mascetti et al.   Cell Stem Cell

From the stem of the placental tree: trophoblast stem cells and their progeny

(2016) Paulina Anna Latos et al.   DEVELOPMENT

Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

(2016) Ludovic Zimmerlin et al.   DEVELOPMENT

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo

(2016) Guangdun Peng et al.   DEVELOPMENTAL CELL

The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion

(2016) Kotaro Sasaki et al.   DEVELOPMENTAL CELL

Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing

(2016) Xiangjin Kang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Inhibition of mTOR induces a paused pluripotent state

(2016) Aydan Bulut-Karslioglu et al.   NATURE

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

A developmental coordinate of pluripotency among mice, monkeys and humans

(2016) Tomonori Nakamura et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

(2016) Leehee Weinberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

YAP Induces Human Naive Pluripotency

(2016) Han Qin et al.   Cell Reports

Self-Organization of Stem Cell Colonies and of Early Mammalian Embryos: Recent Experiments Shed New Light on the Role of Autonomy vs. External Instructions in Basic Body Plan Development

(2016) Hans-Werner Denker   Cells

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

(2015) Kotaro Sasaki et al.   Cell Stem Cell

Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq

(2015) Junchao Shi et al.   DEVELOPMENT

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

(2015) Thorsten Boroviak et al.   DEVELOPMENTAL CELL

Hallmarks of pluripotency

(2015) Alejandro De Los Angeles et al.   NATURE

An alternative pluripotent state confers interspecies chimaeric competency

(2015) Jun Wu et al.   NATURE

Inverted light-sheet microscope for imaging mouse pre-implantation development

(2015) Petr Strnad et al.   NATURE METHODS

The placenta: a multifaceted, transient organ

(2015) G. J. Burton et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells

(2015) Kenichiro Taniguchi et al.   Stem Cell Reports

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human

(2014) Yasuhiro Takashima et al.   CELL

Systematic Identification of Culture Conditions for Induction and Maintenance of Naive Human Pluripotency

(2014) Thorold W. Theunissen et al.   Cell Stem Cell

Bioengineering approaches to guide stem cell-based organogenesis

(2014) Nikolche Gjorevski et al.   DEVELOPMENT

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing

(2014) Fernando H. Biase et al.   GENOME RESEARCH

Single-cell technologies sharpen up mammalian stem cell research

(2014) Philipp S. Hoppe et al.   NATURE CELL BIOLOGY

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

In vitro culture of mouse blastocysts beyond the implantation stages

(2014) Ivan Bedzhov et al.   Nature Protocols

Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo

(2014) I. Bedzhov et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mapping the route from naive pluripotency to lineage specification

(2014) T. Kalkan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo

(2014) M. J. Stower et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Derivation of naive human embryonic stem cells

(2014) C. B. Ware et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells

(2014) Q. Deng et al.   SCIENCE

Dose-dependent Nodal/Smad signals pattern the early mouse embryo

(2014) Elizabeth J. Robertson   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Platform for Induction and Maintenance of Transgene-free hiPSCs Resembling Ground State Pluripotent Stem Cells

(2014) Bahram Valamehr et al.   Stem Cell Reports

Induction of a Human Pluripotent State with Distinct Regulatory Circuitry that Resembles Preimplantation Epiblast

(2013) Yun-Shen Chan et al.   Cell Stem Cell

The Transcriptional and Functional Properties of Mouse Epiblast Stem Cells Resemble the Anterior Primitive Streak

(2013) Yoji Kojima et al.   Cell Stem Cell

Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

(2013) Zhigang Xue et al.   NATURE

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

In-vitro model systems for the study of human embryo–endometrium interactions

(2013) Charlotte H.E. Weimar et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Molecular aspects of implantation failure

(2012) Y.E.M. Koot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Analysis of human embryos from zygote to blastocyst reveals distinct gene expression patterns relative to the mouse

(2012) Kathy K. Niakan et al.   DEVELOPMENTAL BIOLOGY

Dynamics of anterior–posterior axis formation in the developing mouse embryo

(2012) Samantha A. Morris et al.   Nature Communications

Amnion formation in the mouse embryo: the single amniochorionic fold model

(2011) Paulo NG Pereira et al.   BMC DEVELOPMENTAL BIOLOGY

Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells

(2011) Katsuhiko Hayashi et al.   CELL

Self-Organization Phenomena in Embryonic Stem Cell-Derived Embryoid Bodies: Axis Formation and Breaking of Symmetry during Cardiomyogenesis

(2011) Christiane Fuchs et al.   CELLS TISSUES ORGANS

Cell fate decisions and axis determination in the early mouse embryo

(2011) K. Takaoka et al.   DEVELOPMENT

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Oct4 kinetics predict cell lineage patterning in the early mammalian embryo

(2011) Nicolas Plachta et al.   NATURE CELL BIOLOGY

Deterministic and Stochastic Allele Specific Gene Expression in Single Mouse Blastomeres

(2011) Fuchou Tang et al.   PLoS One

Molecular and Functional Characterizations of Gastrula Organizer Cells Derived from Human Embryonic Stem Cells

(2011) Nadav Sharon et al.   STEM CELLS

Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

(2009) J. Rossant et al.   DEVELOPMENT

Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

(2009) Yusuke Marikawa et al.   GENESIS

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Formation of the embryonic-abembryonic axis of the mouse blastocyst: relationships between orientation of early cleavage divisions and pattern of symmetric/asymmetric divisions

(2008) M. Bischoff et al.   DEVELOPMENT