期刊
CELL PROLIFERATION
卷 53, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/cpr.12754
关键词
3D bioengineer; biomaterials; embryo; microenvironment; stem cell
类别
资金
- Key Laboratory of Bio-inspired Materials and Interfacial Science, TIPC, CAS
- Fundamental Research Funds for the Central Universities [FRF-TP-17-051A1]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16020802, XDA16020703]
- State Key Laboratory of Robotics
The abnormalities of early post-implantation embryos can lead to early pregnancy loss and many other syndromes. However, it is hard to study embryos after implantation due to the limited accessibility. The success of embryo culture in vitro can avoid the challenges of embryonic development in vivo and provide a powerful research platform for research in developmental biology. The biophysical and chemical cues of the microenvironments impart significant spatiotemporal effects on embryonic development. Here, we summarize the main strategies which enable researchers to grow embryos outside of the body while overcoming the implantation barrier, highlight the roles of engineered microenvironments in regulating early embryonic development, and finally discuss the future challenges and new insights of early embryo culture.
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