Organoids by design

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Molecular control of macroscopic forces drives formation of the vertebrate hindgut

(2019) Nandan L. Nerurkar et al.   NATURE

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production

(2018) Yukitaka Ito et al.   CELL

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme

(2018) Alex J. Hughes et al.   DEVELOPMENTAL CELL

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Blastocyst-like structures generated solely from stem cells

(2018) Nicolas C. Rivron et al.   NATURE

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Programming gene and engineered-cell therapies with synthetic biology

(2018) Tasuku Kitada et al.   SCIENCE

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Blueprint for an intestinal villus: Species-specific assembly required

(2018) Katherine D. Walton et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Mechanically induced development and maturation of human intestinal organoids in vivo

(2018) Holly M. Poling et al.   Nature Biomedical Engineering

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

(2018) James M. Wells et al.   NATURE

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

(2018) Celina Monteiro Abreu et al.   Frontiers in Microbiology

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Overview of Lung Development in the Newborn Human

(2017) David Warburton   Neonatology

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Advances in on-chip vascularization

(2017) Kristina Haase et al.   Regenerative Medicine

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

(2017) David R Hill et al.   eLife

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation

(2015) Takanori Takebe et al.   Cell Stem Cell

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Investigating biocomplexity through the agent-based paradigm

(2013) H. Kaul et al.   BRIEFINGS IN BIOINFORMATICS

Cytosystems dynamics in self-organization of tissue architecture

(2013) Yoshiki Sasai   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Self-Organization of Animal Tissues: Cadherin-Mediated Processes

(2011) Masatoshi Takeichi   DEVELOPMENTAL CELL

Self-formation of functional adenohypophysis in three-dimensional culture

(2011) Hidetaka Suga et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

Programmed assembly of 3-dimensional microtissues with defined cellular connectivity

(2009) Z. J. Gartner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

Apoptotic Force and Tissue Dynamics During Drosophila Embryogenesis

(2008) Y. Toyama et al.   SCIENCE