Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

Biomimetic Platforms for Human Stem Cell Research

(2011) Gordana Vunjak-Novakovic et al.   Cell Stem Cell

Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals

(2011) Toru Maeda et al.   CURRENT BIOLOGY

Adipogenic Differentiation of Individual Mesenchymal Stem Cell on Different Geometric Micropatterns

(2011) Wei Song et al.   LANGMUIR

Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule Level

(2011) Mark Schvartzman et al.   NANO LETTERS

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro

(2010) Jennifer L. Young et al.   BIOMATERIALS

Actin-Myosin Contractility Is Responsible for the Reduced Viability of Dissociated Human Embryonic Stem Cells

(2010) Guokai Chen et al.   Cell Stem Cell

Sensing substrate rigidity by mechanosensitive ion channels with stress fibers and focal adhesions

(2010) Takeshi Kobayashi et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing

(2010) Coert Margadant et al.   EMBO REPORTS

Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions

(2010) Dong Li et al.   JOURNAL OF CELL BIOLOGY

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Extrinsic regulation of pluripotent stem cells

(2010) Martin F. Pera et al.   NATURE

Cell mechanics and the cytoskeleton

(2010) Daniel A. Fletcher et al.   NATURE

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Soft Substrates Promote Homogeneous Self-Renewal of Embryonic Stem Cells via Downregulating Cell-Matrix Tractions

(2010) Farhan Chowdhury et al.   PLoS One

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development

(2010) T. Maruyama et al.   Science Signaling

Non-muscle myosin II regulates survival threshold of pluripotent stem cells

(2010) Andrea Walker et al.   Nature Communications

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

(2009) Akhilesh Banerjee et al.   BIOMATERIALS

The effect of substrate stiffness on adult neural stem cell behavior

(2009) Nic D. Leipzig et al.   BIOMATERIALS

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth

(2009) João Ferreira-Martins et al.   CIRCULATION RESEARCH

Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics

(2009) E. J. Arnsdorf et al.   JOURNAL OF CELL SCIENCE

Characterization of calcium signaling pathways in human preadipocytes

(2009) Rui Hu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Biomechanical forces promote embryonic haematopoiesis

(2009) Luigi Adamo et al.   NATURE

Designing materials to direct stem-cell fate

(2009) Matthias P. Lutolf et al.   NATURE

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

Microfluidic control of cell pairing and fusion

(2009) Alison M Skelley et al.   NATURE METHODS

Integration of the β-Catenin-Dependent Wnt Pathway with Integrin Signaling through the Adaptor Molecule Grb2

(2009) Steve P. Crampton et al.   PLoS One

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

TGFβ/Activin/Nodal Pathway in Inhibition of Human Embryonic Stem Cell Differentiation by Mechanical Strain

(2008) Somen Saha et al.   BIOPHYSICAL JOURNAL

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor- 1

(2008) J. Ahamed et al.   BLOOD

Prospects for Stem Cell-Based Therapy

(2008) George Q. Daley et al.   CELL

Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development

(2008) Charles E. Murry et al.   CELL

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

(2008) Sean J. Morrison et al.   CELL

Cell adhesion receptors in mechanotransduction

(2008) Martin A Schwartz et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanotransduction - a field pulling together?

(2008) C. S. Chen   JOURNAL OF CELL SCIENCE

Actin stress fibers transmit and focus force to activate mechanosensitive channels

(2008) Kimihide Hayakawa et al.   JOURNAL OF CELL SCIENCE

Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

(2008) Tae-Jin Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Geometric Control of Stem Cell Differentiation Rate on Surfaces

(2008) Wei Luo et al.   LANGMUIR

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emergence of Patterned Stem Cell Differentiation Within Multicellular Structures

(2008) Sami Alom Ruiz et al.   STEM CELLS

Signaling pathways governing stem-cell fate

(2007) U. Blank et al.   BLOOD

No place like home: anatomy and function of the stem cell niche

(2007) D. Leanne Jones et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY