3D Spatiotemporal Mechanical Microenvironment: A Hydrogel-Based Platform for Guiding Stem Cell Fate

Stress relaxing hyaluronic acid-collagen hydrogels promote cell spreading, fiber remodeling, and focal adhesion formation in 3D cell culture

(2018) Junzhe Lou et al.   BIOMATERIALS

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

(2018) Ze Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

(2018) Elisabeth E. Charrier et al.   Nature Communications

Regulation of the fate of dental-derived mesenchymal stem cells using engineered alginate-GelMA hydrogels

(2017) Sahar Ansari et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling

(2017) Christopher M. Madl et al.   NATURE MATERIALS

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels

(2017) William J. Hadden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamically tunable cell culture platforms for tissue engineering and mechanobiology

(2017) Koichiro Uto et al.   PROGRESS IN POLYMER SCIENCE

Human tissues in a dish: The research and ethical implications of organoid technology

(2017) Annelien L. Bredenoord et al.   SCIENCE

Matrix dimensionality and stiffness cooperatively regulate osteogenesis of mesenchymal stromal cells

(2016) Wen-Ting Hsieh et al.   Acta Biomaterialia

A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells

(2016) Haijiao Liu et al.   Acta Biomaterialia

Differentiation of mesenchymal stem cells for cartilage tissue engineering: Individual and synergetic effects of three-dimensional environment and mechanical loading

(2016) J.A. Panadero et al.   Acta Biomaterialia

Wide-range stiffness gradient PVA/HA hydrogel to investigate stem cell differentiation behavior

(2016) Se Heang Oh et al.   Acta Biomaterialia

Labeling and long-term tracking of bone marrow mesenchymal stem cells in vitro using NaYF 4 :Yb 3+ ,Er 3+ upconversion nanoparticles

(2016) Yufei Ma et al.   Acta Biomaterialia

An Integrated Stochastic Model of Matrix-Stiffness-Dependent Filopodial Dynamics

(2016) Bo Cheng et al.   BIOPHYSICAL JOURNAL

Viscoplasticity Enables Mechanical Remodeling of Matrix by Cells

(2016) Sungmin Nam et al.   BIOPHYSICAL JOURNAL

In Vivo Cellular Reprogramming: The Next Generation

(2016) Deepak Srivastava et al.   CELL

Photo-Dimerization Induced Dynamic Viscoelastic Changes in ABA Triblock Copolymer-Based Hydrogels for 3D Cell Culture

(2016) Ryota Tamate et al.   CHEMISTRY OF MATERIALS

Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation

(2016) Matthew S. Rehmann et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

Mechanical plasticity of cells

(2016) Navid Bonakdar et al.   NATURE MATERIALS

Spatially patterned matrix elasticity directs stem cell fate

(2016) Chun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Synthetic hydrogels with stiffness gradients for durotaxis study and tissue engineering scaffolds

(2016) Minji Whang et al.   Tissue Engineering and Regenerative Medicine

4D Bioprinting for Biomedical Applications

(2016) Bin Gao et al.   TRENDS IN BIOTECHNOLOGY

Differentiation Induction of Mouse Neural Stem Cells in Hydrogel Tubular Microenvironments with Controlled Tube Dimensions

(2016) Hiroaki Onoe et al.   Advanced Healthcare Materials

3D Culture of Chondrocytes in Gelatin Hydrogels with Different Stiffness

(2016) Xiaomeng Li et al.   Polymers

Tuning stiffness of cell-laden hydrogel via host–guest interactions

(2016) Han Shih et al.   Journal of Materials Chemistry B

Synthetic hydrogels with stiffness gradients for durotaxis study and tissue engineering scaffolds

(2016) Minji Whang et al.   Tissue Engineering and Regenerative Medicine

The design of reversible hydrogels to capture extracellular matrix dynamics

(2016) Adrianne M. Rosales et al.   Nature Reviews Materials

Paracrine Effects of Adipose-Derived Stem Cells on Matrix Stiffness-Induced Cardiac Myofibroblast Differentiation via Angiotensin II Type 1 Receptor and Smad7

(2016) Kar Wey Yong et al.   Scientific Reports

Interplay of Matrix Stiffness and Cell–Cell Contact in Regulating Differentiation of Stem Cells

(2015) Kai Ye et al.   ACS Applied Materials & Interfaces

Patterning Cellular Alignment through Stretching Hydrogels with Programmable Strain Gradients

(2015) Lin Wang et al.   ACS Applied Materials & Interfaces

Enzyme-mediated hyaluronic acid–tyramine hydrogels for the propagation of human embryonic stem cells in 3D

(2015) Keming Xu et al.   Acta Biomaterialia

Microfluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low-Viscosity Bioink

(2015) Cristina Colosi et al.   ADVANCED MATERIALS

Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering

(2015) Huiyuan Wang et al.   ADVANCED MATERIALS

Directional migration and transcriptional analysis of oligodendrocyte precursors subjected to stimulation of electrical signal

(2015) Yongchao Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Modeling Active Mechanosensing in Cell–Matrix Interactions

(2015) Bin Chen et al.   Annual Review of Biophysics

Dual Ionic and Photo-Crosslinked Alginate Hydrogels for Micropatterned Spatial Control of Material Properties and Cell Behavior

(2015) Julia E. Samorezov et al.   BIOCONJUGATE CHEMISTRY

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

(2015) Kelly M. Mabry et al.   BIOMATERIALS

Differential effects of acellular embryonic matrices on pluripotent stem cell expansion and neural differentiation

(2015) Yuanwei Yan et al.   BIOMATERIALS

Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors

(2015) Sébastien Sart et al.   Biotechnology Journal

Covalent conjugation of mechanically stiff graphene oxide flakes to three-dimensional collagen scaffolds for osteogenic differentiation of human mesenchymal stem cells

(2015) Seokyung Kang et al.   CARBON

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Mechanobiology of myofibroblast adhesion in fibrotic cardiac disease

(2015) A. K. Schroer et al.   JOURNAL OF CELL SCIENCE

The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions

(2015) H. E. Balcioglu et al.   JOURNAL OF CELL SCIENCE

Behavior of CMPCs in unidirectional constrained and stress-free 3D hydrogels

(2015) Mieke H. van Marion et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

(2015) Kai Ye et al.   NANO LETTERS

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

(2015) P. C. Dave P. Dingal et al.   NATURE MATERIALS

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels

(2015) Rajat K. Das et al.   NATURE MATERIALS

A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels

(2015) Cole A. DeForest et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels

(2015) Kelly M. Schultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors

(2015) Jia-Ling Ruan et al.   STEM CELLS

Mouse Embryonic Stem Cell-Derived Cells Reveal Niches that Support Neuronal Differentiation in the Adult Rat Brain

(2015) Guadalupe Maya-Espinosa et al.   STEM CELLS

Substrate Stiffness and Composition Specifically Direct Differentiation of Induced Pluripotent Stem Cells

(2015) Laura Macrí-Pellizzeri et al.   TISSUE ENGINEERING PART A

Stem cell mechanobiology: diverse lessons from bone marrow

(2015) Irena L. Ivanovska et al.   TRENDS IN CELL BIOLOGY

A synthetic hydrogel for the high-throughput study of cell–ECM interactions

(2015) Andrew D. Rape et al.   Nature Communications

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions

(2015) Andrew D. Doyle et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Bridging the Gap: From 2D Cell Culture to 3D Microengineered Extracellular Matrices

(2015) Yanfen Li et al.   Advanced Healthcare Materials

Hybrid Microgels with Thermo-Tunable Elasticity for Controllable Cell Confinement

(2015) Sebastian Hackelbusch et al.   Advanced Healthcare Materials

Regulation of mesenchymal stem cell 3D microenvironment: From macro to microfluidic bioreactors

(2015) Sébastien Sart et al.   Biotechnology Journal

Designed fabrication of super-stiff, anisotropic hybrid hydrogels via linear remodeling of polymer networks and subsequent crosslinking

(2015) Suji Choi et al.   Journal of Materials Chemistry B

Nanoscale viscoelastic properties and adhesion of polydimethylsiloxane for tissue engineering

(2014) J. Chen et al.   ACTA MECHANICA SINICA

Drug discovery through stem cell-based organoid models

(2014) Adrian Ranga et al.   ADVANCED DRUG DELIVERY REVIEWS

Rationally Designed Dynamic Protein Hydrogels with Reversibly Tunable Mechanical Properties

(2014) Na Kong et al.   ADVANCED FUNCTIONAL MATERIALS

Extracellular matrix: A dynamic microenvironment for stem cell niche

(2014) Francesca Gattazzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The crucial role of mechanical heterogeneity in regulating follicle development and ovulation with engineered ovarian microtissue

(2014) Jung Kyu Choi et al.   BIOMATERIALS

Regulation of cell migration and osteogenic differentiation in mesenchymal stem cells under extremely low fluidic shear stress

(2014) Xinghua Gao et al.   Biomicrofluidics

Bioengineering approaches to guide stem cell-based organogenesis

(2014) Nikolche Gjorevski et al.   DEVELOPMENT

Oxidatively Responsive Chain Extension to Entangle Engineered Protein Hydrogels

(2014) Shengchang Tang et al.   MACROMOLECULES

Engineering Anisotropic Biomimetic Fibrocartilage Microenvironment by Bioprinting Mesenchymal Stem Cells in Nanoliter Gel Droplets

(2014) Umut A. Gurkan et al.   MOLECULAR PHARMACEUTICS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

External stimulus-responsive biomaterials designed for the culture and differentiation of ES, iPS, and adult stem cells

(2014) Akon Higuchi et al.   PROGRESS IN POLYMER SCIENCE

In situ-forming injectable hydrogels for regenerative medicine

(2014) Jeong-A. Yang et al.   PROGRESS IN POLYMER SCIENCE

Notch insensitive and self-healing PNIPAm–PAM–clay nanocomposite hydrogels

(2014) Tao Wang et al.   Soft Matter

Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels

(2013) Bin Duan et al.   Acta Biomaterialia

Probing the mechanosensitivity in cell adhesion and migration: Experiments and modeling

(2013) Bao-Hua Ji et al.   ACTA MECHANICA SINICA

Cell-Material Interactions Revealed Via Material Techniques of Surface Patterning

(2013) Xiang Yao et al.   ADVANCED MATERIALS

Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems

(2013) Daniel D. McKinnon et al.   ADVANCED MATERIALS

The influence of substrate stiffness gradients on primary human dermal fibroblasts

(2013) Isabel Hopp et al.   BIOMATERIALS

Modulation of chondrocyte functions and stiffness-dependent cartilage repair using an injectable enzymatically crosslinked hydrogel with tunable mechanical properties

(2013) Li-Shan Wang et al.   BIOMATERIALS

Cells Actively Stiffen Fibrin Networks by Generating Contractile Stress

(2013) Karin A. Jansen et al.   BIOPHYSICAL JOURNAL

Engineering the human pluripotent stem cell microenvironment to direct cell fate

(2013) Laurie B. Hazeltine et al.   BIOTECHNOLOGY ADVANCES

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength

(2013) Ludovic G. Vincent et al.   Biotechnology Journal

Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate

(2013) Akon Higuchi et al.   CHEMICAL REVIEWS

A review on tough and sticky hydrogels

(2013) Charles W. Peak et al.   COLLOID AND POLYMER SCIENCE

Engineering synthetic hydrogel microenvironments to instruct stem cells

(2013) Murat Guvendiren et al.   CURRENT OPINION IN BIOTECHNOLOGY

How cells sense extracellular matrix stiffness: a material's perspective

(2013) Britta Trappmann et al.   CURRENT OPINION IN BIOTECHNOLOGY

External Mechanical Cues Trigger the Establishment of the Anterior-Posterior Axis in Early Mouse Embryos

(2013) Ryuji Hiramatsu et al.   DEVELOPMENTAL CELL

Effects of non-linearity on cell–ECM interactions

(2013) Qi Wen et al.   EXPERIMENTAL CELL RESEARCH

Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates

(2013) Haijiao Liu et al.   JOURNAL OF BIOMECHANICS

At the leading edge of three-dimensional cell migration

(2013) R. J. Petrie et al.   JOURNAL OF CELL SCIENCE

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Gradient static-strain stimulation in a microfluidic chip for 3D cellular alignment

(2013) Hsin-Yi Hsieh et al.   LAB ON A CHIP

Gelatin-Methacrylamide Hydrogels as Potential Biomaterials for Fabrication of Tissue-Engineered Cartilage Constructs

(2013) Wouter Schuurman et al.   MACROMOLECULAR BIOSCIENCE

Responsive biomimetic networks from polyisocyanopeptide hydrogels

(2013) Paul H. J. Kouwer et al.   NATURE

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity

(2013) Tao Lin Sun et al.   NATURE MATERIALS

Role of the extracellular matrix in regulating stem cell fate

(2013) Fiona M. Watt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

(2013) P. Hou et al.   SCIENCE

Hierarchical Hydrogen Bonds Directed Multi-Functional Carbon Nanotube-Based Supramolecular Hydrogels

(2013) Ran Du et al.   Small

Highly Elastic and Superstretchable Graphene Oxide/Polyacrylamide Hydrogels

(2013) Huai-Ping Cong et al.   Small

Dissipative interactions in cell–matrix adhesion

(2013) Christina Müller et al.   Soft Matter

Spontaneous cardiomyocyte differentiation of mouse embryoid bodies regulated by hydrogel crosslink density

(2013) Cindy Chung et al.   Biomaterials Science

Enzymatically cross-linked gelatin-phenol hydrogels with a broader stiffness range for osteogenic differentiation of human mesenchymal stem cells

(2012) Li-Shan Wang et al.   Acta Biomaterialia

The effects of interactive mechanical and biochemical niche signaling on osteogenic differentiation of adipose-derived stem cells using combinatorial hydrogels

(2012) Michelle Nii et al.   Acta Biomaterialia

Control of three-dimensional substrate stiffness to manipulate mesenchymal stem cell fate toward neuronal or glial lineages

(2012) Goh Jih Her et al.   Acta Biomaterialia

Complex Stiffness Gradient Substrates for Studying Mechanotactic Cell Migration

(2012) Cheng-Hwa R. Kuo et al.   ADVANCED MATERIALS

Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment

(2012) Yubing Sun et al.   Annual Review of Biophysics

Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment

(2012) Wei Seong Toh et al.   BIOMATERIALS

The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells

(2012) Teck Chuan Lim et al.   BIOMATERIALS

Chondroitin sulfate and dynamic loading alter chondrogenesis of human MSCs in PEG hydrogels

(2012) Neven J. Steinmetz et al.   BIOTECHNOLOGY AND BIOENGINEERING

In vitro organogenesis in three dimensions: self-organising stem cells

(2012) Y. Sasai et al.   DEVELOPMENT

Controlling Self-Renewal and Differentiation of Stem Cells via Mechanical Cues

(2012) Michele M. Nava et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

The promise of induced pluripotent stem cells in research and therapy

(2012) Daisy A. Robinton et al.   NATURE

Inherent Interfacial Mechanical Gradients in 3D Hydrogels Influence Tumor Cell Behaviors

(2012) Shreyas S. Rao et al.   PLoS One

Designing Cell-Compatible Hydrogels for Biomedical Applications

(2012) D. Seliktar   SCIENCE

Magnitude and presentation of mechanical signals influence adult stem cell behavior in 3-dimensional macroporous hydrogels

(2012) Ross A. Marklein et al.   Soft Matter

Modulation of Mesenchymal Stem Cell Shape in Enzyme-Sensitive Hydrogels Is Decoupled from Upregulation of Fibroblast Markers Under Cyclic Tension

(2012) Peter J. Yang et al.   TISSUE ENGINEERING PART A

Mechanical Stretching for Tissue Engineering: Two-Dimensional and Three-Dimensional Constructs

(2012) Brandon D. Riehl et al.   TISSUE ENGINEERING PART B-REVIEWS

Mimicking dynamic in vivo environments with stimuli-responsive materials for cell culture

(2012) Jungwook Kim et al.   TRENDS IN BIOTECHNOLOGY

Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D

(2012) Edorta Santos et al.   TRENDS IN BIOTECHNOLOGY

Bioprinting for stem cell research

(2012) Savas Tasoglu et al.   TRENDS IN BIOTECHNOLOGY

Computational design of self-assembling register-specific collagen heterotrimers

(2012) Jorge A. Fallas et al.   Nature Communications

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Stem-Cell Niche Based Comparative Analysis of Chemical and Nano-mechanical Material Properties Impacting Ex Vivo Expansion and Differentiation of Hematopoietic and Mesenchymal Stem Cells

(2012) Jinlin Jiang et al.   Advanced Healthcare Materials

Screening of rat mesenchymal stem cell behaviour on polydimethylsiloxane stiffness gradients

(2011) Peng-Yuan Wang et al.   Acta Biomaterialia

Fibroblast Morphology on Dynamic Softening of Hydrogels

(2011) Michelle L. Previtera et al.   ANNALS OF BIOMEDICAL ENGINEERING

Regulation of hepatic stem/progenitor phenotype by microenvironment stiffness in hydrogel models of the human liver stem cell niche

(2011) Oswaldo A. Lozoya et al.   BIOMATERIALS

Differentiation of cardiosphere-derived cells into a mature cardiac lineage using biodegradable poly(N-isopropylacrylamide) hydrogels

(2011) Zhenqing Li et al.   BIOMATERIALS

Stiffness of photocrosslinked RGD-alginate gels regulates adipose progenitor cell behavior

(2011) Emily M. Chandler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Is compressive load a factor in the development of tendinopathy?

(2011) JL Cook et al.   BRITISH JOURNAL OF SPORTS MEDICINE

Calcific Aortic Valve Disease: Not Simply a Degenerative Process

(2011) Nalini M. Rajamannan et al.   CIRCULATION

A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress

(2011) Xinghua Gao et al.   ELECTROPHORESIS

In situ force mapping of mammary gland transformation

(2011) Jose I. Lopez et al.   Integrative Biology

Tendon Biomechanics and Mechanobiology—A Minireview of Basic Concepts and Recent Advancements

(2011) James H-C. Wang et al.   Journal of Hand Therapy

Quantitative Evaluation of Mechanosensing of Cells on Dynamically Tunable Hydrogels

(2011) Hiroshi Y. Yoshikawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate

(2011) Justin R. Tse et al.   PLoS One

Polymers used to influence cell fate in 3D geometry: New trends

(2011) Yukie Aizawa et al.   PROGRESS IN POLYMER SCIENCE

Dynamic Compressive Loading Enhances Cartilage Matrix Synthesis and Distribution and Suppresses Hypertrophy in hMSC-Laden Hyaluronic Acid Hydrogels

(2011) Liming Bian et al.   TISSUE ENGINEERING PART A

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

A matrix micropatterning platform for cell localization and stem cell fate determination

(2010) Ngan F. Huang et al.   Acta Biomaterialia

The effect of 3D hydrogel scaffold modulus on osteoblast differentiation and mineralization revealed by combinatorial screening

(2010) Kaushik Chatterjee et al.   BIOMATERIALS

Biomimetic hydrogels for chondrogenic differentiation of human mesenchymal stem cells to neocartilage

(2010) Shao Qiong Liu et al.   BIOMATERIALS

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro

(2010) Jennifer L. Young et al.   BIOMATERIALS

Characterization of differential properties of rabbit tendon stem cells and tenocytes

(2010) Jianying Zhang et al.   BMC MUSCULOSKELETAL DISORDERS

Stress-relaxation behavior in gels with ionic and covalent crosslinks

(2010) Xuanhe Zhao et al.   JOURNAL OF APPLIED PHYSICS

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Mouse treadmill running enhances tendons by expanding the pool of tendon stem cells (TSCs) and TSC-related cellular production of collagen

(2010) Jianying Zhang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Engineering hydrogels as extracellular matrix mimics

(2010) Hikmet Geckil et al.   Nanomedicine

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Regulatory mechanisms in vascular calcification

(2010) Andrew P. Sage et al.   Nature Reviews Cardiology

Mechanical signals as anabolic agents in bone

(2010) Engin Ozcivici et al.   Nature Reviews Rheumatology

Dynamic Hydrogels: Switching of 3D Microenvironments Using Two-Component Naturally Derived Extracellular Matrices

(2009) Brian M. Gillette et al.   ADVANCED MATERIALS

Effects of cyclic stretch on proliferation of mesenchymal stem cells and their differentiation to smooth muscle cells

(2009) Samane Ghazanfari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method

(2009) Daisuke Sasaki et al.   BIOMATERIALS

The effect of matrix stiffness on mesenchymal stem cell differentiation in a 3D thixotropic gel

(2009) Y. Shona Pek et al.   BIOMATERIALS

Reversible hydrogel formation driven by protein–peptide–specific interaction and chondrocyte entrapment

(2009) Fuyu Ito et al.   BIOMATERIALS

Injectable biodegradable hydrogels with tunable mechanical properties for the stimulation of neurogenesic differentiation of human mesenchymal stem cells in 3D culture

(2009) Li-Shan Wang et al.   BIOMATERIALS

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Hydrogels as extracellular matrix mimics for 3D cell culture

(2009) Mark W. Tibbitt et al.   BIOTECHNOLOGY AND BIOENGINEERING

PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity

(2009) Stephanie Nemir et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

Cellular Receptors of Extracellular Matrix Molecules

(2009) Jyrki Heino et al.   CURRENT PHARMACEUTICAL DESIGN

Effect of fluid flow-induced shear stress on human mesenchymal stem cells: Differential gene expression of IL1B and MAP3K8 in MAPK signaling

(2009) John R. Glossop et al.   GENE EXPRESSION PATTERNS

Biomechanical forces promote embryonic haematopoiesis

(2009) Luigi Adamo et al.   NATURE

Non-Linear Elasticity of Extracellular Matrices Enables Contractile Cells to Communicate Local Position and Orientation

(2009) Jessamine P. Winer et al.   PLoS One

Vascular effects of a low-carbohydrate high-protein diet

(2009) S. Y. Foo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels

(2009) E. A. Sander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential crosslinking to control cellular spreading in 3-dimensional hydrogels

(2009) Sudhir Khetan et al.   Soft Matter

Shear Stress Induces Nitric Oxide–Mediated Vascular Endothelial Growth Factor Production in Human Adipose Tissue Mesenchymal Stem Cells

(2009) Vinícius Bassaneze et al.   STEM CELLS AND DEVELOPMENT

Dynamic Mechanical Loading Enhances Functional Properties of Tissue-Engineered Cartilage Using Mature Canine Chondrocytes

(2009) Liming Bian et al.   TISSUE ENGINEERING PART A

Silicon Scaffolds Promoting Three-Dimensional Neuronal Web of Cytoplasmic Processes

(2009) Evie L. Papadopoulou et al.   TISSUE ENGINEERING PART C-METHODS

Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation

(2008) Andrew S. Rowlands et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Mechanical Environment of Bone Marrow: A Review

(2008) Umut Atakan Gurkan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells

(2008) S.D. Thorpe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Small-diameter human vessel wall engineered from bone marrow-derived mesenchymal stem cells (hMSCs)

(2008) Zhaodi Gong et al.   FASEB JOURNAL

Extracellular matrix dynamics in development and regenerative medicine

(2008) W. P. Daley et al.   JOURNAL OF CELL SCIENCE

Smart Hydrogels Containing Adenylate Kinase: Translating Substrate Recognition into Macroscopic Motion

(2008) Weiwei Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering Applications

(2008) Garret D. Nicodemus et al.   TISSUE ENGINEERING PART B-REVIEWS

Controlled differentiation of stem cells

(2007) Nathaniel S. Hwang et al.   ADVANCED DRUG DELIVERY REVIEWS

Biomaterials for stem cell differentiation

(2007) Eileen Dawson et al.   ADVANCED DRUG DELIVERY REVIEWS