Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells

From morphogen to morphogenesis and back

(2017) Darren Gilmour et al.   NATURE

Mechanics of neurulation: From classical to current perspectives on the physical mechanics that shape, fold, and form the neural tube

(2017) Deepthi S. Vijayraghavan et al.   Birth Defects Research

A Balance between Secreted Inhibitors and Edge Sensing Controls Gastruloid Self-Organization

(2016) Fred Etoc et al.   DEVELOPMENTAL CELL

Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

(2016) Shinuo Weng et al.   NATURE MATERIALS

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Cell Density Sensing Alters TGF-β Signaling in a Cell-Type-Specific Manner, Independent from Hippo Pathway Activation

(2015) Flore Nallet-Staub et al.   DEVELOPMENTAL CELL

Tissue patterning and cellular mechanics

(2015) Evan Heller et al.   JOURNAL OF CELL BIOLOGY

Desktop aligner for fabrication of multilayer microfluidic devices

(2015) Xiang Li et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

BMP gradients: A paradigm for morphogen-mediated developmental patterning

(2015) E. Bier et al.   SCIENCE

Microfluidic-assisted cyclic mechanical stimulation affects cellular membrane integrity in a human muscular dystrophy in vitro model

(2015) F. Michielin et al.   RSC Advances

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

(2014) Yubing Sun et al.   NATURE MATERIALS

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

BMP growth factor signaling in a biomechanical context

(2013) Jessica Kopf et al.   BIOFACTORS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Defined Human Pluripotent Stem Cell Culture Enables Highly Efficient Neuroepithelium Derivation Without Small Molecule Inhibitors

(2013) Ethan Scott Lippmann et al.   STEM CELLS

Modeling Neural Crest Induction, Melanocyte Specification, and Disease-Related Pigmentation Defects in hESCs and Patient-Specific iPSCs

(2013) Yvonne Mica et al.   Cell Reports

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Neural crest induction at the neural plate border in vertebrates

(2012) Cécile Milet et al.   DEVELOPMENTAL BIOLOGY

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

(2012) Thomas O'Leary et al.   NATURE BIOTECHNOLOGY

Physical Biology Returns to Morphogenesis

(2012) R. Keller   SCIENCE

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

Synthetic polymer coatings for long-term growth of human embryonic stem cells

(2010) Luis G Villa-Diaz et al.   NATURE BIOTECHNOLOGY

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network

(2010) N. de Croze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential requirements of BMP and Wnt signalling during gastrulation and neurulation define two steps in neural crest induction

(2009) B. Steventon et al.   DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

A gene regulatory network orchestrates neural crest formation

(2008) Tatjana Sauka-Spengler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recombinant Vitronectin Is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-Renewal via αVβ5 Integrin

(2008) Stefan R. Braam et al.   STEM CELLS